MetaCyc Pathway: superpathway of S-adenosyl-L-methionine biosynthesis in Klebsiella michiganensis M5al

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Reactions and Genes RCH2_defined_noCarbon with Supernatant; Trichoderma virens G41 grown in Fungal_growth_media_mCAFEs_v1, filtered and pH-adjusted 0.67x
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Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
BWI76_RS00790 -0.1
BWI76_RS01790 -1.2
BWI76_RS04245 -1.4
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
BWI76_RS12880 +0.2
BWI76_RS20385 +0.8
BWI76_RS26220 N.D.
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
BWI76_RS00790 -0.1
BWI76_RS04245 -1.4
Homoserine O-succinyltransferase:
L-homoserine + succinyl-CoA→O-succinyl-L-homoserine + coenzyme A (EC 2.3.1.46)
BWI76_RS01655 -0.4
Cystathionine gamma-synthase:
O-succinyl-L-homoserine + L-cysteine→L-cystathionine + H+ + succinate (EC 2.5.1.48)
BWI76_RS00785 -0.1
BWI76_RS16730 -0.1
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate (EC 4.4.1.13)
BWI76_RS16300 +0.7
BWI76_RS24285 +0.3
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate (EC 2.1.1.14)
BWI76_RS01280 -0.3
BWI76_RS15390 -0.0
Methionine synthase:
L-homocysteine + a 5-methyltetrahydrofolate→L-methionine + a tetrahydrofolate (EC 2.1.1.13)
BWI76_RS01685 -0.2
Methionine adenosyltransferase:
L-methionine + ATP + H2O→S-adenosyl-L-methionine + diphosphate + phosphate (EC 2.5.1.6)
BWI76_RS24050 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information