MetaCyc Pathway: H. pylori 26695 O-antigen biosynthesis in Bacteroides thetaiotaomicron VPI-5482

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Reactions and Genes Varel_Bryant_medium_Glucose with Trimethoprim 0.025 mM
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UDP-N-acetyl-α-D-glucosamine + di-trans,octa-cis-undecaprenyl phosphate→α-D-GlcNAc-PP-Und + UMP (EC 2.7.8.33)
BT0056 +0.2
BT0396 -1.6
BT1339 +0.4
BT2888 +0.3
α-D-GlcNAc-PP-Und + GDP-β-L-fucose→β-L-Fuc-(1→3)-α-D-GlcNAc-PP-Und + GDP + H+
No genes
β-L-Fuc-(1→3)-α-D-GlcNAc-PP-Und + ADP-D-glycero-β-D-manno-heptose→α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + ADP + H+
No genes
α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + UDP-α-D-glucose→α-D-Glu-(1→6)-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + H+ + UDP
No genes
α-D-Glu-(1→6)-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + UDP-α-D-glucose→[α-D-Glu-(1→6)]2-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + H+ + UDP
No genes
[α-D-Glu-(1→6)]2-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + UDP-α-D-glucose→[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + H+ + UDP
No genes
[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + UDP-α-D-glucose→α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + H+ + UDP
No genes
α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + ADP-D-glycero-β-D-manno-heptose→α-D,D-Hep-(1→3)-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + ADP + H+
No genes
α-D,D-Hep-(1→3)-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + ADP-D-glycero-β-D-manno-heptose→[α-D,D-Hep-(1→3)]2-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + ADP + H+
No genes
[α-D,D-Hep-(1→3)]2-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + ADP-D-glycero-β-D-manno-heptose→[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + ADP + H+
No genes
[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + UDP-N-acetyl-α-D-glucosamine→α-D-GlcNAc-(1→2)-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + H+ + UDP
No genes
Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase:
α-D-GlcNAc-(1→2)-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + UDP-α-D-galactose→β-D-Gal-(1→4)-α-D-GlcNAc-(1→2)-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + H+ + UDP (EC 2.4.1.38)
No genes
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase:
β-D-Gal-(1→4)-α-D-GlcNAc-(1→2)-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + GDP-β-L-fucose→β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-α-D-GlcNAc-(1→2)-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + GDP + H+ (EC 2.4.1.152)
No genes
β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-α-D-GlcNAc-(1→2)-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + UDP-N-acetyl-α-D-glucosamine→α-D-GlcNAc-(1→2)-β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-α-D-GlcNAc-(1→2)-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + H+ + UDP
No genes
Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase:
α-D-GlcNAc-(1→2)-β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-α-D-GlcNAc-(1→2)-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + UDP-α-D-galactose→β-D-Gal-(1→4)-α-D-GlcNAc-(1→2)-β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-α-D-GlcNAc-(1→2)-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + H+ + UDP (EC 2.4.1.38)
No genes
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase:
β-D-Gal-(1→4)-α-D-GlcNAc-(1→2)-β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-α-D-GlcNAc-(1→2)-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + GDP-β-L-fucose→{β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-α-D-GlcNAc-(1→2)}2-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + GDP + H+ (EC 2.4.1.152)
No genes
{β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-α-D-GlcNAc-(1→2)}2-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + UDP-N-acetyl-α-D-glucosamine→β-D-GlcNAc-(1→3)-{β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-α-D-GlcNAc-(1→2)}2-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + H+ + UDP
No genes
Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase:
β-D-GlcNAc-(1→3)-{β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-α-D-GlcNAc-(1→2)}2-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + UDP-α-D-galactose→β-D-Gal-(1→4)-β-D-GlcNAc-(1→3)-{β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-α-D-GlcNAc-(1→2)}2-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + H+ + UDP (EC 2.4.1.38)
No genes
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase:
β-D-Gal-(1→4)-β-D-GlcNAc-(1→3)-{β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-α-D-GlcNAc-(1→2)}2-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + GDP-β-L-fucose→β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-β-D-GlcNAc-(1→3)-{β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-α-D-GlcNAc-(1→2)}2-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + GDP + H+ (EC 2.4.1.152)
No genes
β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-β-D-GlcNAc-(1→3)-{β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-α-D-GlcNAc-(1→2)}2-[α-D,D-Hep-(1→3)]3-α-D-Glu-(1→3)-[α-D-Glu-(1→6)]3-α-D,D-Hep-(1→3)-β-L-Fuc-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + GDP-β-L-fucose→Helicobacter pylori O-antigen + GDP + H+ (EC 2.4.1.344)
No genes
Helicobacter pylori O-antigen[in] + ATP[in] + H2O[in]→Helicobacter pylori O-antigen[out] + ADP[in] + H+[in] + phosphate[in] (EC 7.5.2.14)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information