MetaCyc Pathway: ceramide and sphingolipid recycling and degradation (yeast) in Pseudomonas stutzeri RCH2

Add experiment(s):


Reactions and Genes Ethanol (C)
remove
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine + H2O→a very-long-chain (2'R)-2'-hydroxy-phytoceramide + 1D-myo-inositol 1-monophosphate + H+
No genes
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-{[6-O-(α-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl}sphinganine + H2O→a very-long-chain (2'R)-2'-hydroxy-phytoceramide + phosphoinositol-α-mannoside + H+
No genes
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[hydroxy(6-O-{6-O-[(1D-myo-inositol-1-O-yl)phosphoryl]-α-D-mannosyl}-1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine + H2O→a very-long-chain (2'R)-2'-hydroxy-phytoceramide + phosphoinositol-α-mannoside-phosphoinositol
No genes
Ceramidase:
a dihydroceramide + H2O→sphinganine + a carboxylate (EC 3.5.1.23)
No genes
Ceramidase:
a very-long-chain (2'R)-2'-hydroxy-phytoceramide + H2O→a phytosphingosine + a very-long-chain (2R)-2-hydroxy fatty acid (EC 3.5.1.23)
No genes
Sphinganine kinase:
sphinganine + ATP→sphinganine 1-phosphate + ADP + H+ (EC 2.7.1.91)
No genes
sphinganine 1-phosphate + H2O→sphinganine + phosphate
No genes
Sphinganine kinase:
phytosphingosine + ATP→phytosphingosine (C18) 1-phosphate + ADP + H+ (EC 2.7.1.91)
No genes
Sphinganine-1-phosphate aldolase:
sphinganine 1-phosphate→hexadecanal + O-phosphoethanolamine (EC 4.1.2.27)
No genes
Sphinganine-1-phosphate aldolase:
phytosphingosine (C18) 1-phosphate→(R)-2-hydroxyhexadecanal + O-phosphoethanolamine (EC 4.1.2.27)
No genes
Aldehyde dehydrogenase (NAD(+)):
hexadecanal + NAD+ + H2O→palmitate + NADH + 2 H+ (EC 1.2.1.3)
Psest_2276 -2.6
Psest_0247 +0.1
Psest_0375 +0.0
Psest_4305 -0.3
Psest_0671 -0.1
Psest_0905 +0.1
phytosphingosine (C18) 1-phosphate + H2O→phytosphingosine + phosphate
No genes
Aldehyde dehydrogenase (NAD(+)):
(R)-2-hydroxyhexadecanal + NAD+ + H2O→(R)-2-hydroxyhexadecanoate + NADH + 2 H+ (EC 1.2.1.3)
Psest_2276 -2.6
Psest_0247 +0.1
Psest_0375 +0.0
Psest_4305 -0.3
Psest_0671 -0.1
Psest_0905 +0.1
Long-chain-fatty-acid--CoA ligase:
palmitate + ATP + coenzyme A→palmitoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
Psest_1086 -0.0
Psest_1334 -0.3
Psest_1335 +0.1
Psest_2477 +0.0
(R)-2-hydroxyhexadecanoate + dioxygen→pentadecanoate + CO2 + H2O (EC 1.14.18.12)
No genes
Long-chain-fatty-acid--CoA ligase:
pentadecanoate + ATP + coenzyme A→pentadecanoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
Psest_1086 -0.0
Psest_1334 -0.3
Psest_1335 +0.1
Psest_2477 +0.0

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information