Fitness data for Rv0050 in Mycobacterium tuberculosis H37Rv

Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)
SEED: Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-)

Top 20 experiments with the strongest phenotypes (|fitness| ≥ 0.7)


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group condition fitness t score  
stress 7H9 with Pretomanid 0.213 ug/mL -2.2 -4.8 compare
stress 7H9 with Pretomanid 0.213 ug/mL -1.7 -4.3 compare
stress 7H9 with Ethambutol 0.75 ug/mL -1.7 -2.6 compare
stress 7H9 with Moxifloxacin 0.121 ug/mL -1.6 -2.6 compare
stress 7H9 with Meropenem 9.6 ug/mL -1.4 -2.8 compare
stress 7H9 with Rifampicin 0.014 ug/mL -1.4 -2.1 compare
carbon source Valeric 10 mM (C) -1.3 -3.4 compare
stress 7H9 with Sulfamethizole 0.026 mM -1.1 -2.6 compare
carbon source Stearic 100 uM (C) -1.0 -2.0 compare
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.9 -2.2 compare
stress 7H9 with Ethionamide 0.1 ug/mL -0.9 -1.6 compare
carbon source L-Aspartic Acid (C) -0.9 -2.9 compare
stress 7H9 with Streptomycin 0.178 ug/mL -0.8 -1.9 compare
carbon source D-Glucose (C) -0.8 -1.6 compare
no stress control no stress control -0.8 -1.5 compare
carbon source L-Aspartic Acid (C) -0.8 -1.7 compare
stress 7H9 with Delamanid 0.236 ug/mL -0.8 -1.9 compare
carbon source L-Lactate 10 mM (C) -0.7 -2.4 compare
carbon source Glycerol (C) -0.7 -2.2 compare
stress 7H9 with Isoniazid 0.025 ug/mL +0.7 +0.9 compare