Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3889c and Rv3890c are separated by 95 nucleotidesRv3890c and Rv3891c are separated by 35 nucleotidesRv3891c and Rv3892c are separated by 111 nucleotidesRv3892c and Rv3893c are separated by 78 nucleotides Rv3889c: Rv3889c - ESX-2 secretion-associated protein EspG2, at 4,372,800 to 4,373,630 Rv3889c Rv3890c: Rv3890c - ESAT-6 like protein EsxC (ESAT-6 like protein 11), at 4,373,726 to 4,374,013 Rv3890c Rv3891c: Rv3891c - Possible ESAT-6 like protein EsxD, at 4,374,049 to 4,374,372 Rv3891c Rv3892c: Rv3892c - PPE family protein PPE69, at 4,374,484 to 4,375,683 Rv3892c Rv3893c: Rv3893c - PE family protein PE36, at 4,375,762 to 4,375,995 Rv3893c
Group Condition Rv3889c Rv3890c Rv3891c Rv3892c Rv3893c
stress 7H9 with Isoniazid 0.025 ug/mL -0.1 -0.4 -0.4 -0.3 -0.4
nitrogen source L-Glutamic 10 mM (N) +0.0 -0.1 -0.2 +0.1 -0.7
nitrogen source L-Valine 10 mM (N) -0.1 -0.1 -0.1 -0.1 -0.5
stress 7H9 with Levofloxacin 0.3 ug/mL -0.1 -0.1 -0.3 +0.3 -0.5
carbon source D-Lactate 10 mM (C) -0.2 +0.1 -0.6 -0.1 -0.0
no stress control no stress control -0.2 +0.0 -0.4 -0.2 +0.1
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.0 -0.0 -0.4 +0.2 -0.4
stress 7H9 with Rifampicin 0.014 ug/mL -0.1 -0.4 -0.5 +0.0 +0.4
carbon source D-Lactate 10 mM (C) -0.2 +0.4 -0.5 -0.1 -0.1
nitrogen source L-Glutamic 10 mM (N) -0.2 +0.3 -0.1 -0.1 -0.3
stress 7H9 with Clofazimine 0.45 ug/mL +0.0 -0.2 -0.6 +0.3 +0.1
stress 7H9 with Ethionamide 0.1 ug/mL +0.1 +0.2 -0.2 +0.2 -0.6
stress 7H9 with Linezolid 0.44 ug/mL -0.1 -0.1 -0.3 -0.3 +0.5
carbon source D-Trehalose 10 mM (C) +0.0 +0.4 -0.1 +0.0 -0.5
stress 7H9 with Clofazimine 0.072 ug/mL +0.1 -0.2 -0.4 +0.1 +0.3
stress 7H9 with Ofloxacin 0.8 ug/mL +0.0 +0.3 -0.1 +0.1 -0.4
stress 7H9 with Ethambutol 0.75 ug/mL -0.1 +0.4 -0.5 -0.1 +0.3
carbon source L-Lactate 10 mM (C) -0.0 +0.4 -0.2 +0.1 -0.2
nitrogen source L-Glutamine 10 mM (N) -0.2 +0.4 +0.2 -0.2 -0.2
stress 7H9 with Sulfamethizole 0.026 mM +0.0 -0.1 -0.4 +0.0 +0.4
carbon source casaminos 1 mg/mL (C) -0.1 +0.4 -0.1 -0.2 +0.2
stress 7H9 with Sulfamethizole 0.026 mM -0.2 -0.2 +0.4 +0.1 +0.1
carbon source Valeric 10 mM (C) +0.2 +0.0 +0.4 -0.1 -0.2
no stress control no stress control +0.2 +0.1 +0.2 +0.1 -0.3
stress 7H9 with Isoniazid 0.025 ug/mL -0.3 +0.1 +0.1 +0.1 +0.5
stress 7H9 with Clofazimine 0.072 ug/mL -0.2 +0.1 -0.2 +0.1 +0.6
stress 7H9 with Hygromycin B 0.0095 mM -0.1 +0.2 +0.3 -0.1 +0.2
stress 7H9 with Delamanid 0.236 ug/mL +0.0 -0.1 +0.5 +0.2 -0.2
nitrogen source Glycine 10 mM (N) +0.1 +0.3 +0.2 -0.1 +0.3
stress 7H9 with Meropenem 9.6 ug/mL -0.1 +0.4 +0.1 -0.1 +0.7
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