Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3873 and Rv3874 are separated by 92 nucleotidesRv3874 and Rv3875 are separated by 32 nucleotidesRv3875 and Rv3876 are separated by 113 nucleotidesRv3876 and Rv3877 overlap by 4 nucleotides Rv3873: Rv3873 - PPE family protein PPE68, at 4,351,075 to 4,352,181 Rv3873 Rv3874: Rv3874 - 10 kDa culture filtrate antigen EsxB (LHP) (CFP10), at 4,352,274 to 4,352,576 Rv3874 Rv3875: Rv3875 - 6 kDa early secretory antigenic target EsxA (ESAT-6), at 4,352,609 to 4,352,896 Rv3875 Rv3876: Rv3876 - ESX-1 secretion-associated protein EspI. Conserved proline and alanine rich protein., at 4,353,010 to 4,355,010 Rv3876 Rv3877: Rv3877 - ESX conserved component EccD1. ESX-1 type VII secretion system protein. Probable transmembrane protein., at 4,355,007 to 4,356,542 Rv3877
Group Condition Rv3873 Rv3874 Rv3875 Rv3876 Rv3877
stress 7H9 with Ethionamide 0.1 ug/mL -0.1 -2.6 N.D. -0.3 -0.1
carbon source D-Trehalose 10 mM (C) +0.1 -2.4 N.D. -0.3 +0.0
stress 7H9 with Ramoplanin 0.009 mM -0.2 -2.4 N.D. +0.1 +0.3
carbon source acetate (C) +0.3 -1.5 N.D. -0.3 -0.2
stress 7H9 with Formaldehyde 0.23 mM -0.1 -1.5 N.D. -0.1 +0.1
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 +0.3 -1.7 N.D. +0.1 -0.0
nitrogen source Ammonium chloride 10mM (N) +0.0 -1.7 N.D. +0.0 +0.3
carbon source oleate 200uM (C) -0.2 -1.5 N.D. +0.2 +0.2
nitrogen source Urea 10mM (N) +0.0 -1.6 N.D. +0.3 +0.1
stress 7H9 with Rifampicin 0.014 ug/mL +0.1 -1.4 N.D. +0.1 +0.1
carbon source D,L-Malic Acid 10 mM (C) +0.2 -1.5 N.D. +0.1 +0.2
stress 7H9 with Tetrazolium violet 0.065 mM +0.2 -1.2 N.D. +0.0 +0.2
stress 7H9 with Lomefloxacin 0.0035 mM +0.4 -1.1 N.D. +0.1 -0.1
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM +0.0 -1.2 N.D. +0.2 +0.3
pH pH 4.5 +0.2 -1.1 N.D. +0.3 +0.0
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 +0.4 -1.2 N.D. +0.1 +0.3
stress 7H9 with Econazole nitrate salt 0.0082 mM +0.3 -1.0 N.D. +0.3 +0.1
no stress control no stress control +0.0 +1.4 N.D. +0.1 -0.2
stress 7H9 with Plumbagin 0.01 mM -0.1 +1.4 N.D. -0.0 +0.2
nitrogen source L-Asparagine 10 mM (N) -0.1 +1.1 N.D. +0.3 +0.2
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM +0.2 +1.1 N.D. +0.3 +0.0
stress 7H9 with Irgasan 0.065 mM -0.0 +1.4 N.D. +0.1 +0.1
nitrogen source L-Glutamine 10 mM (N) +0.2 +1.2 N.D. +0.2 -0.0
stress 7H9 with Menadione 0.005 mM +0.0 +1.6 N.D. -0.1 +0.1
stress 7H9 with Novobiocin 0.004 mM +0.5 +0.4 N.D. +0.3 +0.5
stress 7H9 with Phenazine methosulfate 0.0054 mM +0.1 +1.8 N.D. -0.0 -0.0
stress 7H9 with Tetrazolium violet 0.065 mM +0.3 +1.8 N.D. +0.2 +0.0
stress 7H9 with Sisomicin 0.07 mM +0.3 +1.5 N.D. +0.4 +0.1
stress 7H9 with Levofloxacin 0.3 ug/mL +0.0 +2.4 N.D. -0.0 +0.1
stress 7H9 with Cumene hydroperoxide 0.05 mM +0.1 +2.0 N.D. +0.1 +0.3
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