Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3872 and Rv3873 are separated by 30 nucleotidesRv3873 and Rv3874 are separated by 92 nucleotidesRv3874 and Rv3875 are separated by 32 nucleotidesRv3875 and Rv3876 are separated by 113 nucleotides Rv3872: Rv3872 - PE family-related protein PE35, at 4,350,745 to 4,351,044 Rv3872 Rv3873: Rv3873 - PPE family protein PPE68, at 4,351,075 to 4,352,181 Rv3873 Rv3874: Rv3874 - 10 kDa culture filtrate antigen EsxB (LHP) (CFP10), at 4,352,274 to 4,352,576 Rv3874 Rv3875: Rv3875 - 6 kDa early secretory antigenic target EsxA (ESAT-6), at 4,352,609 to 4,352,896 Rv3875 Rv3876: Rv3876 - ESX-1 secretion-associated protein EspI. Conserved proline and alanine rich protein., at 4,353,010 to 4,355,010 Rv3876
Group Condition Rv3872 Rv3873 Rv3874 Rv3875 Rv3876
stress 7H9 with Ramoplanin 0.009 mM -0.6 -0.2 -2.4 N.D. +0.1
stress 7H9 with Ethionamide 0.1 ug/mL +0.1 -0.1 -2.6 N.D. -0.3
carbon source D-Trehalose 10 mM (C) +0.1 +0.1 -2.4 N.D. -0.3
stress 7H9 with Formaldehyde 0.23 mM -0.2 -0.1 -1.5 N.D. -0.1
carbon source acetate (C) -0.3 +0.3 -1.5 N.D. -0.3
carbon source D,L-Malic Acid 10 mM (C) -0.3 +0.2 -1.5 N.D. +0.1
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM -0.5 +0.0 -1.2 N.D. +0.2
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 +0.0 +0.3 -1.7 N.D. +0.1
carbon source oleate 200uM (C) +0.3 -0.2 -1.5 N.D. +0.2
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -0.4 +0.4 -1.2 N.D. +0.1
pH pH 4.5 -0.3 +0.2 -1.1 N.D. +0.3
nitrogen source Ammonium chloride 10mM (N) +0.8 +0.0 -1.7 N.D. +0.0
nitrogen source Urea 10mM (N) +0.4 +0.0 -1.6 N.D. +0.3
stress 7H9 with Tetrazolium violet 0.065 mM +0.2 +0.2 -1.2 N.D. +0.0
stress 7H9 with Lomefloxacin 0.0035 mM +0.2 +0.4 -1.1 N.D. +0.1
stress 7H9 with Delamanid 0.236 ug/mL -0.6 -0.2 +0.9 N.D. -0.2
stress 7H9 with Zinc Pyrithione 0.00072 mM -0.5 +0.1 +1.0 N.D. +0.0
stress 7H9 with Lomefloxacin 0.0035 mM +1.0 +0.3 -0.5 N.D. +0.0
stress 7H9 with Irgasan 0.065 mM -0.3 -0.0 +1.4 N.D. +0.1
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM -0.3 +0.2 +1.1 N.D. +0.3
stress 7H9 with Hydrogen peroxide 3.97 mM +0.8 -0.2 +0.7 N.D. -0.0
stress 7H9 with Menadione 0.005 mM -0.2 +0.0 +1.6 N.D. -0.1
nitrogen source L-Asparagine 10 mM (N) +0.2 -0.1 +1.1 N.D. +0.3
stress 7H9 with Plumbagin 0.01 mM +0.3 -0.1 +1.4 N.D. -0.0
nitrogen source L-Glutamine 10 mM (N) +0.2 +0.2 +1.2 N.D. +0.2
stress 7H9 with Tetrazolium violet 0.065 mM -0.3 +0.3 +1.8 N.D. +0.2
stress 7H9 with Phenazine methosulfate 0.0054 mM +0.2 +0.1 +1.8 N.D. -0.0
stress 7H9 with Cumene hydroperoxide 0.05 mM -0.0 +0.1 +2.0 N.D. +0.1
stress 7H9 with Levofloxacin 0.3 ug/mL +0.0 +0.0 +2.4 N.D. -0.0
stress 7H9 with Sisomicin 0.07 mM +0.6 +0.3 +1.5 N.D. +0.4
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