Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3846 and Rv3847 are separated by 210 nucleotidesRv3847 and Rv3848 are separated by 254 nucleotidesRv3848 and Rv3849 are separated by 264 nucleotidesRv3849 and Rv3850 are separated by 117 nucleotides Rv3846: Rv3846 - Superoxide dismutase [FE] SodA, at 4,320,704 to 4,321,327 Rv3846 Rv3847: Rv3847 - Hypothetical protein, at 4,321,538 to 4,322,071 Rv3847 Rv3848: Rv3848 - Probable conserved transmembrane protein, at 4,322,326 to 4,323,234 Rv3848 Rv3849: Rv3849 - ESX-1 transcriptional regulatory protein EspR, at 4,323,499 to 4,323,897 Rv3849 Rv3850: Rv3850 - Conserved protein, at 4,324,015 to 4,324,671 Rv3850
Group Condition Rv3846 Rv3847 Rv3848 Rv3849 Rv3850
stress 7H9 with nitrite 3 mM; pH 5.5 N.D. -0.4 -0.8 N.D. -2.9
no stress control no stress control N.D. -0.1 +0.1 N.D. -3.4
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 N.D. -0.2 -1.6 N.D. -1.5
no stress control no stress control N.D. -0.5 -0.4 N.D. -2.4
no stress control no stress control N.D. +0.2 -1.3 N.D. -2.0
nitrogen source Ammonium chloride 10mM (N) N.D. -0.2 -0.0 N.D. -2.7
stress 7H9 with Nickel (II) chloride 0.6 mM N.D. -0.1 -1.9 N.D. -0.8
no stress control no stress control N.D. -0.3 -0.9 N.D. -1.6
carbon source propionate (C) N.D. -0.1 -2.8 N.D. +0.2
nitrogen source Urea 10mM (N) N.D. +0.0 +0.1 N.D. -2.7
stress 7H9 with Doxycycline hyclate 0.0035 mM N.D. -0.1 +0.6 N.D. -3.1
carbon source butyrate 10 mM (C) N.D. -0.0 +1.1 N.D. -3.6
nitrogen source Glycine 10 mM (N) N.D. -0.1 +0.1 N.D. -2.5
carbon source D-Trehalose 10 mM (C) N.D. -0.2 +0.8 N.D. -2.7
stress 7H9 with Ethionamide 0.1 ug/mL N.D. +0.3 -0.5 N.D. -1.8
no stress control no stress control N.D. -0.0 +0.3 N.D. -2.3
carbon source Glycerol (C) N.D. +0.2 +0.7 N.D. -2.8
carbon source propionate (C) N.D. -0.1 -3.2 N.D. +1.3
stress 7H9 with 2,4-Dinitrophenol 0.1503 mM N.D. -0.3 +1.2 N.D. -2.6
no stress control no stress control N.D. -0.2 +1.0 N.D. -2.5
nitrogen source L-Asparagine 10 mM (N) N.D. -0.1 +0.9 N.D. -1.9
stress 7H9 with Sisomicin 0.07 mM N.D. -0.2 +1.4 N.D. -1.2
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM N.D. -0.5 +1.4 N.D. -0.8
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM N.D. -0.4 +1.6 N.D. -1.1
stress 7H9 with Antimycin A 0.0186 mM N.D. -0.2 +1.5 N.D. -1.1
stress 7H9 with Menadione 0.005 mM N.D. -0.1 +1.7 N.D. -1.2
carbon source oleate 200uM (C) N.D. -0.2 +2.0 N.D. +0.7
stress 7H9 with Norfloxacin 0.125 mM N.D. -0.1 +1.3 N.D. +1.4
carbon source cholesterol 100uM (C) N.D. -0.2 +1.7 N.D. +1.6
carbon source cholesterol 100uM (C) N.D. -0.1 +1.4 N.D. +1.8
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