Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3764c and Rv3765c are separated by 70 nucleotidesRv3765c and Rv3766 are separated by 508 nucleotidesRv3766 and Rv3767c are separated by 13 nucleotidesRv3767c and Rv3768 are separated by 129 nucleotides Rv3764c: Rv3764c - Possible two component sensor kinase TcrY, at 4,209,582 to 4,211,009 Rv3764c Rv3765c: Rv3765c - Probable two component transcriptional regulatory protein TcrX, at 4,211,080 to 4,211,784 Rv3765c Rv3766: Rv3766 - Hypothetical protein, at 4,212,293 to 4,212,982 Rv3766 Rv3767c: Rv3767c - Possible S-adenosylmethionine-dependent methyltransferase, at 4,212,996 to 4,213,940 Rv3767c Rv3768: Rv3768 - Unknown protein, at 4,214,070 to 4,214,429 Rv3768
Group Condition Rv3764c Rv3765c Rv3766 Rv3767c Rv3768
carbon source heptadecanoic 250 uM (C) N.D. +0.1 -2.4 -0.2 -1.1
carbon source oleate 200uM (C) N.D. +0.2 -3.1 -0.1 +0.2
carbon source Stearic 100 uM (C) N.D. +0.2 -2.7 -0.1 -0.1
carbon source Palmitic 100 uM (C) N.D. -0.0 -0.8 -0.1 -1.7
carbon source heptadecanoic 250 uM (C) N.D. +0.0 -1.8 -0.2 -0.7
carbon source Stearic 100 uM (C) N.D. +0.2 -2.2 -0.1 -0.5
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 N.D. -0.0 -0.1 -0.3 -1.1
carbon source L-Lactate 10 mM (C) N.D. +0.1 -0.8 -0.2 -0.6
carbon source butyrate 10 mM (C) N.D. -0.0 -0.4 +0.1 -0.9
carbon source oleate 200uM (C) N.D. +0.3 -2.0 +0.2 +0.3
stress 7H9 with copper (II) chloride 0.08 mM N.D. -0.1 -0.4 +0.2 -0.9
stress 7H9 with nitrite 2.5 mM N.D. +0.2 -0.4 +0.0 -1.0
stress 7H9 with Sisomicin 0.07 mM N.D. +0.2 -0.0 +0.2 -1.5
stress 7H9 with Chloramphenicol 0.01 mM N.D. +0.3 -0.4 -0.4 -0.5
stress 7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM N.D. +0.2 +0.1 -0.2 -1.2
stress 7H9 with Cloxacillin 0.0386 mM N.D. +0.2 +0.3 -0.1 -0.9
pH 7H9 pH 5.5 N.D. -0.1 -0.6 -0.4 +0.7
pH pH 4.5 N.D. +0.3 -0.4 +0.3 -0.5
no stress control no stress control N.D. +0.4 +0.2 +0.2 -0.9
pH 7H9 pH 5.5 N.D. -0.0 -0.6 -0.2 +0.9
stress 7H9 with Linezolid 0.44 ug/mL N.D. -0.0 -0.6 -0.2 +0.9
stress 7H9 with Levofloxacin 0.3 ug/mL N.D. -0.1 -0.5 +0.0 +0.8
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. +0.1 -0.3 -0.1 +0.9
stress 7H9 with Amikacin di2 ug/mL N.D. +0.2 -0.3 -0.2 +1.0
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM N.D. +0.3 -0.7 -0.2 +1.4
stress 7H9 with Isoniazid 0.025 ug/mL N.D. -0.2 -0.3 +0.1 +1.3
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM N.D. +0.1 +0.8 -0.3 +0.4
nitrogen source L-Glutamic 10 mM (N) N.D. +0.1 +0.5 +0.0 +1.0
nitrogen source L-Serine 10 mM (N) N.D. +0.1 +0.6 +0.3 +0.9
stress 7H9 with Isoniazid 0.025 ug/mL N.D. +0.2 -0.1 +0.2 +1.7
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