Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3674c and Rv3675 are separated by 107 nucleotidesRv3675 and Rv3676 are separated by 98 nucleotidesRv3676 and Rv3677c are separated by 105 nucleotidesRv3677c and Rv3678c are separated by 6 nucleotides Rv3674c: Rv3674c - Probable endonuclease III Nth (DNA-(apurinic or apyrimidinic site)lyase) (AP lyase) (AP endonuclease class I) (endodeoxyribonuclease (apurinic or apyrimidinic)) (deoxyribonuclease (apurinic or apyrimidinic)), at 4,115,157 to 4,115,894 Rv3674c Rv3675: Rv3675 - Possible membrane protein, at 4,116,002 to 4,116,379 Rv3675 Rv3676: Rv3676 - Transcriptional regulatory protein Crp (Crp/Fnr-family), at 4,116,478 to 4,117,152 Rv3676 Rv3677c: Rv3677c - Possible hydrolase, at 4,117,258 to 4,118,052 Rv3677c Rv3678c: Rv3678c - Conserved protein, at 4,118,059 to 4,118,514 Rv3678c
Group Condition Rv3674c Rv3675 Rv3676 Rv3677c Rv3678c
nitrogen source L-Glutamine 10 mM (N) -0.4 -0.6 N.D. -0.2 N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.2 -1.0 N.D. +0.1 N.D.
stress 7H9 with Ethionamide 0.1 ug/mL -0.5 -0.8 N.D. +0.3 N.D.
stress 7H9 with Isoniazid 0.025 ug/mL -0.0 -1.2 N.D. +0.2 N.D.
no stress control no stress control -0.1 -0.7 N.D. -0.2 N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.1 -0.7 N.D. -0.2 N.D.
nitrogen source L-Valine 10 mM (N) -0.3 -0.5 N.D. -0.1 N.D.
nitrogen source L-Alanine 10 mM (N) -0.0 -0.6 N.D. -0.3 N.D.
no stress control no stress control -0.3 -0.9 N.D. +0.3 N.D.
stress 7H9 with Isoniazid 0.025 ug/mL -0.3 -0.6 N.D. +0.0 N.D.
nitrogen source L-Glutamic 10 mM (N) -0.2 -0.6 N.D. -0.0 N.D.
nitrogen source L-Asparagine 10 mM (N) +0.1 -0.7 N.D. -0.1 N.D.
stress 7H9 with Pretomanid 0.213 ug/mL -0.1 -0.5 N.D. +0.0 N.D.
nitrogen source Glycine 10 mM (N) -0.1 -0.5 N.D. +0.1 N.D.
stress 7H9 with Streptomycin 0.178 ug/mL -0.0 -0.4 N.D. -0.1 N.D.
stress 7H9 with Clofazimine 0.45 ug/mL -0.3 -0.5 N.D. +0.2 N.D.
stress 7H9 with Levofloxacin 0.3 ug/mL +0.2 -0.8 N.D. +0.2 N.D.
nitrogen source L-Aspartic Acid 10 mM (N) -0.2 -0.4 N.D. +0.2 N.D.
stress 7H9 with Ethionamide 0.1 ug/mL +0.1 -0.5 N.D. +0.0 N.D.
carbon source L-Asparagine (C) +0.2 -0.5 N.D. +0.0 N.D.
stress 7H9 with Clofazimine 0.072 ug/mL -0.3 -0.1 N.D. +0.3 N.D.
carbon source propionate (C) +0.1 -0.3 N.D. +0.1 N.D.
stress 7H9 with Sulfamethizole 0.026 mM +0.3 -0.3 N.D. -0.1 N.D.
nitrogen source L-Glutamine 10 mM (N) +0.1 -0.3 N.D. +0.1 N.D.
no stress control no stress control +0.0 -0.3 N.D. +0.2 N.D.
carbon source heptadecanoic 250 uM (C) +0.1 +0.4 N.D. -0.5 N.D.
stress 7H9 with Linezolid 0.44 ug/mL -0.3 +0.2 N.D. +0.2 N.D.
stress 7H9 with Clarithromycin 0.967 ug/mL +0.2 -0.3 N.D. +0.1 N.D.
carbon source D-Glucose (C) -0.3 +0.3 N.D. +0.2 N.D.
carbon source Valeric 10 mM (C) -0.2 +0.4 N.D. +0.3 N.D.
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