Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3652 and Rv3653 overlap by 7 nucleotidesRv3653 and Rv3654c are separated by 132 nucleotidesRv3654c and Rv3655c are separated by 8 nucleotidesRv3655c and Rv3656c are separated by 23 nucleotides Rv3652: Rv3652 - PE-PGRS family-related protein PE_PGRS60, at 4,093,632 to 4,093,946 Rv3652 Rv3653: Rv3653 - PE-PGRS family-related protein PE_PGRS61, at 4,093,940 to 4,094,527 Rv3653 Rv3654c: Rv3654c - Conserved hypothetical protein, at 4,094,660 to 4,094,914 Rv3654c Rv3655c: Rv3655c - Conserved hypothetical protein, at 4,094,923 to 4,095,300 Rv3655c Rv3656c: Rv3656c - Conserved hypothetical protein, at 4,095,324 to 4,095,530 Rv3656c
Group Condition Rv3652 Rv3653 Rv3654c Rv3655c Rv3656c
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM -0.1 N.D. N.D. -2.5 N.D.
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM -0.6 N.D. N.D. -1.7 N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL -1.0 N.D. N.D. -1.1 N.D.
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM -0.3 N.D. N.D. -1.8 N.D.
stress 7H9 with Phenazine methosulfate 0.0054 mM -0.2 N.D. N.D. -1.4 N.D.
stress 7H9 with Isoniazid 0.025 ug/mL -0.7 N.D. N.D. -0.9 N.D.
stress 7H9 with Benzethonium chloride 0.068 mM -0.5 N.D. N.D. -1.0 N.D.
stress 7H9 with para-aminosalicylic 0.086 ug/mL -0.3 N.D. N.D. -1.1 N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.2 N.D. N.D. -1.3 N.D.
no stress control no stress control -0.4 N.D. N.D. -1.0 N.D.
stress 7H9 with Hygromycin B 0.0095 mM -0.3 N.D. N.D. -1.2 N.D.
stress 7H9 with Amikacin di2 ug/mL +0.0 N.D. N.D. -1.4 N.D.
stress 7H9 with Ethionamide 0.1 ug/mL -0.6 N.D. N.D. -0.8 N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.6 N.D. N.D. -0.7 N.D.
stress 7H9 with 8-hydroxy-nitroquinoline 0.03 mM -0.2 N.D. N.D. -1.1 N.D.
stress 7H9 with Doxycycline hyclate 0.0035 mM -0.3 N.D. N.D. -1.0 N.D.
stress 7H9 with Ciprofloxacin Hydrochloride 0.0012 mM +0.2 N.D. N.D. -1.4 N.D.
nitrogen source Ammonium chloride 10mM (N) +0.2 N.D. N.D. -1.4 N.D.
stress 7H9 with Phenazine ethosulfate 0.0137 mM -0.1 N.D. N.D. -1.0 N.D.
stress 7H9 with Lomefloxacin 0.0035 mM -0.4 N.D. N.D. -0.6 N.D.
stress 7H9 with Delamanid 0.236 ug/mL +0.1 N.D. N.D. -1.2 N.D.
stress 7H9 with Clarithromycin 0.967 ug/mL +0.1 N.D. N.D. -1.0 N.D.
stress 7H9 with nitrite 1.5 mM; pH 5.5 +0.2 N.D. N.D. -1.0 N.D.
carbon source cholesterol 100uM (C) +0.6 N.D. N.D. -1.1 N.D.
stress 7H9 with Amikacin di2 ug/mL +0.3 N.D. N.D. -0.8 N.D.
no stress control no stress control -0.7 N.D. N.D. +0.4 N.D.
nitrogen source L-Glutamic 10 mM (N) -0.6 N.D. N.D. +0.5 N.D.
stress 7H9 with Isoniazid 0.025 ug/mL -0.6 N.D. N.D. +0.7 N.D.
pH pH 5.5 +0.5 N.D. N.D. +0.7 N.D.
stress 7H9 with copper (II) chloride 0.08 mM +0.0 N.D. N.D. +1.4 N.D.
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