Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3646c and Rv3647c are separated by 352 nucleotidesRv3647c and Rv3648c are separated by 139 nucleotidesRv3648c and Rv3649 are separated by 249 nucleotidesRv3649 and Rv3650 are separated by 136 nucleotides Rv3646c: Rv3646c - DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (nicking-closing enzyme) (TOPO I), at 4,084,453 to 4,087,257 Rv3646c Rv3647c: Rv3647c - Conserved hypothetical protein, at 4,087,610 to 4,088,188 Rv3647c Rv3648c: Rv3648c - Probable cold shock protein A CspA, at 4,088,328 to 4,088,531 Rv3648c Rv3649: Rv3649 - Probable helicase, at 4,088,781 to 4,091,096 Rv3649 Rv3650: Rv3650 - PE family protein PE33, at 4,091,233 to 4,091,517 Rv3650
Group Condition Rv3646c Rv3647c Rv3648c Rv3649 Rv3650
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. -3.7 N.D. +0.4 -0.0
stress 7H9 with Isoniazid 0.025 ug/mL N.D. -0.4 N.D. +0.0 -1.7
stress 7H9 with Delamanid 0.236 ug/mL N.D. -0.3 N.D. +0.4 -2.2
carbon source casaminos 1 mg/mL (C) N.D. -0.4 N.D. +0.2 -1.7
nitrogen source L-Alanine 10 mM (N) N.D. +0.5 N.D. -0.5 -1.8
stress 7H9 with Rifampicin 0.00045 ug/mL N.D. -0.6 N.D. -0.4 -0.9
carbon source Valeric 10 mM (C) N.D. -0.5 N.D. -0.1 -1.2
no stress control no stress control N.D. +0.3 N.D. -0.5 -1.6
stress 7H9 with Ethionamide 0.1 ug/mL N.D. -1.1 N.D. -0.1 -0.4
stress 7H9 with Streptomycin 0.178 ug/mL N.D. -0.0 N.D. -0.3 -1.3
stress 7H9 with Clofazimine 0.45 ug/mL N.D. +0.0 N.D. -0.3 -1.3
carbon source Palmitic 100 uM (C) N.D. +0.0 N.D. -0.3 -1.3
carbon source L-Glutamine (C) N.D. -0.3 N.D. +0.1 -1.2
stress 7H9 with Sulfaquinoxaline 0.097 mM N.D. -0.7 N.D. +0.1 -0.9
stress 7H9 with Levofloxacin 0.3 ug/mL N.D. -1.2 N.D. +0.2 -0.4
carbon source Stearic 100 uM (C) N.D. +0.4 N.D. -0.1 -1.6
carbon source propionate (C) N.D. +0.1 N.D. +0.3 -1.6
stress 7H9 with Meropenem 9.6 ug/mL N.D. +0.5 N.D. -0.2 -1.5
stress 7H9 with Streptomycin 0.178 ug/mL N.D. +0.4 N.D. -0.7 -0.8
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. -0.8 N.D. +0.4 -0.5
nitrogen source L-Serine 10 mM (N) N.D. +0.6 N.D. -0.6 -0.8
nitrogen source Glycine 10 mM (N) N.D. +0.5 N.D. -0.3 -0.9
carbon source Glycerol (C) N.D. +0.2 N.D. +0.2 -1.1
stress 7H9 with Pretomanid 0.213 ug/mL N.D. +0.7 N.D. -0.0 -1.2
nitrogen source L-Glutamic 10 mM (N) N.D. +0.9 N.D. +0.4 -1.6
no stress control no stress control N.D. +0.8 N.D. -0.3 -0.7
nitrogen source L-Glutamic 10 mM (N) N.D. +0.7 N.D. +0.2 -1.0
stress 7H9 with Clofazimine 0.072 ug/mL N.D. +0.8 N.D. +0.2 -0.5
stress 7H9 with Linezolid 0.44 ug/mL N.D. +0.1 N.D. -0.2 +1.2
carbon source acetate (C) N.D. +0.6 N.D. -0.0 +1.7
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