Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3618 and Rv3619c are separated by 98 nucleotidesRv3619c and Rv3620c are separated by 26 nucleotidesRv3620c and Rv3621c are separated by 56 nucleotidesRv3621c and Rv3622c are separated by 9 nucleotides Rv3618: Rv3618 - Possible monooxygenase, at 4,058,698 to 4,059,885 Rv3618 Rv3619c: Rv3619c - Putative ESAT-6 like protein EsxV (ESAT-6 like protein 1), at 4,059,984 to 4,060,268 Rv3619c Rv3620c: Rv3620c - Putative ESAT-6 like protein EsxW (ESAT-6 like protein 10), at 4,060,295 to 4,060,591 Rv3620c Rv3621c: Rv3621c - PPE family protein PPE65, at 4,060,648 to 4,061,889 Rv3621c Rv3622c: Rv3622c - PE family protein PE32, at 4,061,899 to 4,062,198 Rv3622c
Group Condition Rv3618 Rv3619c Rv3620c Rv3621c Rv3622c
stress 7H9 with Ofloxacin 0.8 ug/mL -0.4 N.D. N.D. -0.2 -0.5
stress 7H9 with Ofloxacin 0.8 ug/mL -0.6 N.D. N.D. -0.3 -0.1
stress 7H9 with Linezolid 0.44 ug/mL +0.1 N.D. N.D. -0.3 -0.7
stress 7H9 with Novobiocin 0.004 mM -0.4 N.D. N.D. -0.2 -0.3
stress 7H9 with Isoniazid 0.025 ug/mL -0.2 N.D. N.D. -0.2 -0.5
stress 7H9 with Clarithromycin 0.967 ug/mL -0.2 N.D. N.D. -0.0 -0.5
stress 7H9 with hypochlorite 0.4 vol% -0.2 N.D. N.D. -0.1 -0.5
no stress control no stress control -0.3 N.D. N.D. -0.2 -0.2
stress 7H9 with Dibucaine 0.21 mM -0.1 N.D. N.D. -0.1 -0.5
nitrogen source L-Glutamine 10 mM (N) -0.3 N.D. N.D. +0.1 -0.4
no stress control no stress control -0.2 N.D. N.D. +0.0 -0.4
stress 7H9 with Phenazine ethosulfate 0.0137 mM +0.1 N.D. N.D. -0.1 -0.6
stress 7H9 with nitrite 1.5 mM; pH 5.5 +0.2 N.D. N.D. +0.0 -0.5
stress 7H9 with Zinc Pyrithione 0.00072 mM -0.2 N.D. N.D. -0.3 +0.4
no stress control no stress control +0.3 N.D. N.D. -0.1 -0.2
stress 7H9 with Amikacin di2 ug/mL +0.3 N.D. N.D. +0.1 -0.3
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM +0.3 N.D. N.D. +0.1 -0.4
stress 7H9 with 2,4-Dinitrophenol 0.1503 mM +0.2 N.D. N.D. -0.3 +0.3
stress 7H9 with Irgasan 0.065 mM -0.2 N.D. N.D. -0.0 +0.5
no stress control no stress control -0.2 N.D. N.D. -0.1 +0.6
stress 7H9 with Norfloxacin 0.125 mM -0.2 N.D. N.D. +0.1 +0.5
stress 7H9 with Ethionamide 0.1 ug/mL -0.2 N.D. N.D. +0.1 +0.6
stress 7H9 with Cloxacillin 0.0386 mM +0.1 N.D. N.D. -0.1 +0.4
stress 7H9 with Dicloxacillin 0.0069 mM +0.1 N.D. N.D. +0.1 +0.5
stress 7H9 with Benzethonium chloride 0.068 mM +0.1 N.D. N.D. +0.1 +0.5
stress 7H9 with Spectinomycin 0.029 mM +0.4 N.D. N.D. +0.1 +0.3
stress 7H9 with nitrite 2.5 mM -0.1 N.D. N.D. -0.0 +0.9
stress 7H9 with Pretomanid 0.213 ug/mL +0.5 N.D. N.D. +0.3 +0.1
stress 7H9 with copper (II) chloride 0.08 mM +0.3 N.D. N.D. +0.1 +0.6
stress 7H9 with Sutezolid 0.12 ug/mL +0.3 N.D. N.D. +0.3 +0.6
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