Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3606c and Rv3607c overlap by 4 nucleotidesRv3607c and Rv3608c overlap by 8 nucleotidesRv3608c and Rv3609c overlap by 4 nucleotidesRv3609c and Rv3610c are separated by 15 nucleotides Rv3606c: Rv3606c - 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) (2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase) (7,8-dihydro-6-hydroxymethylpterin-diphosphokinase) (6-hydroxymethyl-7,8-dihydropterin diphosphokinase), at 4,048,181 to 4,048,747 Rv3606c Rv3607c: Rv3607c - Probable dihydroneopterin aldolase FolB (DHNA), at 4,048,744 to 4,049,145 Rv3607c Rv3608c: Rv3608c - Dihydropteroate synthase 1 FolP (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate diphosphorylase 1), at 4,049,138 to 4,049,980 Rv3608c Rv3609c: Rv3609c - GTP cyclohydrolase I FolE (GTP-ch-I), at 4,049,977 to 4,050,585 Rv3609c Rv3610c: Rv3610c - Membrane-bound protease FtsH (cell division protein), at 4,050,601 to 4,052,883 Rv3610c
Group Condition Rv3606c Rv3607c Rv3608c Rv3609c Rv3610c
stress 7H9 with Streptomycin 0.178 ug/mL N.D. N.D. N.D. N.D. -3.8
stress 7H9 with Streptomycin 0.178 ug/mL N.D. N.D. N.D. N.D. -3.0
stress 7H9 with Hygromycin B 0.0095 mM N.D. N.D. N.D. N.D. -2.6
stress 7H9 with Isoniazid 0.025 ug/mL N.D. N.D. N.D. N.D. -2.4
stress 7H9 with Sulfamethizole 0.026 mM N.D. N.D. N.D. N.D. -2.2
stress 7H9 with Hygromycin B 0.0095 mM N.D. N.D. N.D. N.D. -2.0
stress 7H9 with Sulfamethizole 0.026 mM N.D. N.D. N.D. N.D. -1.8
stress 7H9 with Sisomicin 0.07 mM N.D. N.D. N.D. N.D. -1.7
stress 7H9 with Sisomicin 0.07 mM N.D. N.D. N.D. N.D. -1.6
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM N.D. N.D. N.D. N.D. -1.6
carbon source propionate (C) N.D. N.D. N.D. N.D. -1.5
carbon source propionate (C) N.D. N.D. N.D. N.D. -1.5
stress 7H9 with hypochlorite 0.4 vol% N.D. N.D. N.D. N.D. -1.4
carbon source Valeric 10 mM (C) N.D. N.D. N.D. N.D. -1.4
stress 7H9 with Menadione 0.005 mM N.D. N.D. N.D. N.D. -1.4
no stress control no stress control N.D. N.D. N.D. N.D. -1.3
stress 7H9 with Thioridazine 0.028 mM N.D. N.D. N.D. N.D. -1.3
nitrogen source Urea 10mM (N) N.D. N.D. N.D. N.D. -1.3
nitrogen source Ammonium chloride 10mM (N) N.D. N.D. N.D. N.D. -1.3
stress 7H9 with Phenazine methosulfate 0.0054 mM N.D. N.D. N.D. N.D. -1.3
stress 7H9 with Phenazine ethosulfate 0.0137 mM N.D. N.D. N.D. N.D. -1.2
stress 7H9 with hypochlorite 0.4 vol% N.D. N.D. N.D. N.D. -1.2
stress 7H9 with Econazole nitrate salt 0.0082 mM N.D. N.D. N.D. N.D. -1.1
carbon source Stearic 100 uM (C) N.D. N.D. N.D. N.D. -1.1
no stress control no stress control N.D. N.D. N.D. N.D. -1.1
stress 7H9 with Econazole nitrate salt 0.0082 mM N.D. N.D. N.D. N.D. -1.1
nitrogen source L-Alanine 10 mM (N) N.D. N.D. N.D. N.D. -1.1
carbon source L-Lactate 10 mM (C) N.D. N.D. N.D. N.D. -1.0
pH pH 5.5 N.D. N.D. N.D. N.D. +1.1
stress 7H9 with Ethambutol 0.75 ug/mL N.D. N.D. N.D. N.D. +1.1
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