Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3573c and Rv3574 are separated by 271 nucleotidesRv3574 and Rv3575c are separated by 5 nucleotidesRv3575c and Rv3576 are separated by 189 nucleotidesRv3576 and Rv3577 are separated by 190 nucleotides Rv3573c: Rv3573c - Probable acyl-CoA dehydrogenase FadE34, at 4,014,077 to 4,016,212 Rv3573c Rv3574: Rv3574 - Transcriptional regulatory protein KstR (probably TetR-family), at 4,016,484 to 4,017,083 Rv3574 Rv3575c: Rv3575c - Transcriptional regulatory protein (probably LacI-family), at 4,017,089 to 4,018,168 Rv3575c Rv3576: Rv3576 - Possible conserved lipoprotein LppH, at 4,018,358 to 4,019,071 Rv3576 Rv3577: Rv3577 - Conserved hypothetical protein, at 4,019,262 to 4,020,128 Rv3577
Group Condition Rv3573c Rv3574 Rv3575c Rv3576 Rv3577
carbon source propionate (C) -0.0 N.D. -1.3 -0.4 -0.1
carbon source butyrate 10 mM (C) +0.3 N.D. -1.5 -0.7 +0.3
carbon source propionate (C) +0.0 N.D. -1.2 -0.4 +0.1
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.2 N.D. -0.3 -0.4 -0.4
stress 7H9 with Isoniazid 0.025 ug/mL -0.3 N.D. -0.0 -0.9 -0.2
carbon source butyrate 10 mM (C) +0.4 N.D. -1.6 +0.3 -0.1
no stress control no stress control -0.6 N.D. -0.3 -0.2 -0.0
nitrogen source L-Valine 10 mM (N) -0.2 N.D. -0.2 -0.6 -0.0
stress 7H9 with Ethionamide 0.1 ug/mL +0.0 N.D. -0.3 -0.6 -0.2
carbon source Stearic 100 uM (C) +0.3 N.D. -0.7 -0.4 -0.1
stress 7H9 with Streptomycin 0.178 ug/mL -0.4 N.D. +0.0 -0.5 -0.1
stress 7H9 with Meropenem 9.6 ug/mL -0.0 N.D. -0.5 -0.1 -0.3
stress 7H9 with Rifampicin 0.014 ug/mL -0.1 N.D. -0.0 -0.4 -0.3
stress 7H9 with Ofloxacin 0.8 ug/mL +0.1 N.D. -0.2 -0.4 -0.2
carbon source L-Glutamine (C) +0.2 N.D. -0.4 -0.4 -0.1
carbon source casaminos 1 mg/mL (C) -0.1 N.D. +0.2 -0.8 +0.1
carbon source heptadecanoic 250 uM (C) +0.1 N.D. -0.4 -0.3 +0.1
carbon source pyruvate (C) -0.1 N.D. +0.1 -0.3 -0.3
nitrogen source L-Asparagine 10 mM (N) +0.1 N.D. -0.5 -0.3 +0.1
carbon source Stearic 100 uM (C) +0.1 N.D. -0.7 +0.1 -0.0
stress 7H9 with Ofloxacin 0.8 ug/mL +0.2 N.D. -0.4 +0.1 -0.3
carbon source L-Lactate 10 mM (C) -0.1 N.D. -0.1 -0.4 +0.2
carbon source L-Glutamine (C) -0.1 N.D. -0.4 +0.2 -0.0
carbon source L-Lactate 10 mM (C) +0.2 N.D. -0.3 -0.5 +0.2
carbon source Glycerol (C) +0.1 N.D. -0.2 -0.4 +0.2
stress 7H9 with Clofazimine 0.45 ug/mL +0.4 N.D. -0.1 -0.1 -0.4
stress 7H9 with Meropenem 9.6 ug/mL +0.3 N.D. -0.3 +0.2 -0.1
stress 7H9 with Hygromycin B 0.0095 mM +0.1 N.D. -0.2 +0.5 -0.2
carbon source Valeric 10 mM (C) +0.0 N.D. -0.3 +0.3 +0.3
carbon source casaminos 1 mg/mL (C) +0.2 N.D. +0.3 -0.2 +0.1
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