Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3572 and Rv3573c are separated by 35 nucleotidesRv3573c and Rv3574 are separated by 271 nucleotidesRv3574 and Rv3575c are separated by 5 nucleotidesRv3575c and Rv3576 are separated by 189 nucleotides Rv3572: Rv3572 - Unknown protein, at 4,013,511 to 4,014,041 Rv3572 Rv3573c: Rv3573c - Probable acyl-CoA dehydrogenase FadE34, at 4,014,077 to 4,016,212 Rv3573c Rv3574: Rv3574 - Transcriptional regulatory protein KstR (probably TetR-family), at 4,016,484 to 4,017,083 Rv3574 Rv3575c: Rv3575c - Transcriptional regulatory protein (probably LacI-family), at 4,017,089 to 4,018,168 Rv3575c Rv3576: Rv3576 - Possible conserved lipoprotein LppH, at 4,018,358 to 4,019,071 Rv3576
Group Condition Rv3572 Rv3573c Rv3574 Rv3575c Rv3576
carbon source butyrate 10 mM (C) -0.2 +0.3 N.D. -1.5 -0.7
carbon source propionate (C) -0.0 -0.0 N.D. -1.3 -0.4
carbon source propionate (C) -0.0 +0.0 N.D. -1.2 -0.4
stress 7H9 with Isoniazid 0.025 ug/mL +0.0 -0.3 N.D. -0.0 -0.9
carbon source butyrate 10 mM (C) -0.2 +0.4 N.D. -1.6 +0.3
nitrogen source L-Valine 10 mM (N) -0.1 -0.2 N.D. -0.2 -0.6
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.0 -0.2 N.D. -0.3 -0.4
no stress control no stress control +0.0 -0.6 N.D. -0.3 -0.2
nitrogen source L-Asparagine 10 mM (N) -0.4 +0.1 N.D. -0.5 -0.3
carbon source Stearic 100 uM (C) -0.2 +0.3 N.D. -0.7 -0.4
carbon source heptadecanoic 250 uM (C) -0.4 -0.0 N.D. -0.4 -0.1
carbon source L-Lactate 10 mM (C) -0.3 -0.1 N.D. -0.1 -0.4
stress 7H9 with Meropenem 9.6 ug/mL -0.3 -0.0 N.D. -0.5 -0.1
stress 7H9 with Streptomycin 0.178 ug/mL -0.1 -0.4 N.D. +0.0 -0.5
carbon source heptadecanoic 250 uM (C) -0.3 +0.1 N.D. -0.4 -0.3
carbon source Stearic 100 uM (C) -0.4 +0.1 N.D. -0.7 +0.1
stress 7H9 with Clarithromycin 0.967 ug/mL -0.3 -0.1 N.D. -0.2 -0.3
carbon source casaminos 1 mg/mL (C) -0.2 -0.1 N.D. +0.2 -0.8
carbon source L-Glutamine (C) -0.1 +0.2 N.D. -0.4 -0.4
carbon source L-Lactate 10 mM (C) -0.1 +0.2 N.D. -0.3 -0.5
stress 7H9 with Rifampicin 0.014 ug/mL -0.4 +0.1 N.D. -0.2 -0.2
stress 7H9 with Ethionamide 0.1 ug/mL +0.1 +0.0 N.D. -0.3 -0.6
nitrogen source L-Asparagine 10 mM (N) -0.3 +0.1 N.D. -0.2 -0.3
stress 7H9 with Clofazimine 0.45 ug/mL -0.7 +0.4 N.D. -0.1 -0.1
carbon source Valeric 10 mM (C) -0.2 +0.1 N.D. -0.5 +0.2
stress 7H9 with Ethionamide 0.1 ug/mL +0.2 -0.1 N.D. -0.4 +0.1
stress 7H9 with Clofazimine 0.45 ug/mL -0.5 +0.1 N.D. -0.1 +0.3
carbon source casaminos 1 mg/mL (C) -0.5 +0.2 N.D. +0.3 -0.2
nitrogen source L-Glutamine 10 mM (N) -0.3 +0.3 N.D. -0.3 +0.1
stress 7H9 with Hygromycin B 0.0095 mM +0.1 +0.1 N.D. -0.2 +0.5
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