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Fitness for 5 genes in
Mycobacterium tuberculosis H37Rv
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500 nt
Rv3499c and Rv3500c are separated by 19 nucleotides
Rv3500c and Rv3501c are separated by 34 nucleotides
Rv3501c and Rv3502c are separated by 225 nucleotides
Rv3502c and Rv3503c are separated by 24 nucleotides
Rv3499c: Rv3499c - Mce-family protein Mce4A, at 3,917,998 to 3,919,200
Rv3499c
Rv3500c: Rv3500c - Conserved integral membrane protein YrbE4B. Possible ABC transporter., at 3,919,220 to 3,920,062
Rv3500c
Rv3501c: Rv3501c - Conserved integral membrane protein YrbE4A. Possible ABC transporter., at 3,920,097 to 3,920,861
Rv3501c
Rv3502c: Rv3502c - Probable short-chain type dehydrogenase/reductase. Possible 17-beta-hydroxysteroid dehydrogenase., at 3,921,087 to 3,922,040
Rv3502c
Rv3503c: Rv3503c - Probable ferredoxin FdxD, at 3,922,065 to 3,922,256
Rv3503c
Group
Condition
Rv3499c
Rv3500c
Rv3501c
Rv3502c
Rv3503c
carbon source
Glycerol (C)
-1.1
-1.0
-1.6
-0.4
-0.2
carbon source
Glycerol (C)
-1.4
-1.0
-1.1
-0.4
+0.1
stress
7H9 with Meropenem 9.6 ug/mL
-1.1
-0.9
-1.0
-0.2
+0.0
stress
7H9 with Meropenem 9.6 ug/mL
-0.8
-1.2
-1.0
-0.1
-0.0
nitrogen source
L-Asparagine 10 mM (N)
-1.2
-0.9
-0.8
+0.0
-0.3
carbon source
butyrate 10 mM (C)
-0.5
-0.7
-0.9
-0.1
-0.4
nitrogen source
Glycine 10 mM (N)
-0.7
-0.8
-0.5
+0.1
-0.5
stress
7H9 with Clofazimine 0.45 ug/mL
-0.7
-0.8
-0.7
-0.2
+0.0
stress
7H9 with Dimethyl Sulfoxide 1 vol%
-0.8
-0.7
-0.6
-0.2
-0.2
nitrogen source
Glycine 10 mM (N)
-0.8
-0.8
-0.3
-0.0
-0.4
carbon source
butyrate 10 mM (C)
-0.6
-0.6
-0.8
-0.0
-0.2
carbon source
L-Asparagine (C)
-0.7
-0.6
-0.6
-0.3
+0.0
nitrogen source
L-Asparagine 10 mM (N)
-0.6
-0.7
-0.5
-0.0
-0.2
nitrogen source
L-Aspartic Acid 10 mM (N)
-0.7
-0.6
-0.7
-0.2
+0.1
carbon source
Stearic 100 uM (C)
-0.5
-0.6
-0.4
+0.1
-0.6
stress
7H9 with Clofazimine 0.45 ug/mL
-0.6
-0.6
-0.4
-0.2
+0.0
carbon source
propionate (C)
-0.4
-0.5
-0.5
-0.5
+0.1
no stress control
no stress control
-0.5
-0.5
-0.6
-0.1
+0.0
nitrogen source
L-Glutamine 10 mM (N)
-0.7
-0.6
-0.4
+0.1
-0.1
no stress control
no stress control
-0.5
-0.5
-0.4
-0.2
-0.0
carbon source
L-Glutamine (C)
-0.5
-0.5
-0.2
-0.3
-0.1
carbon source
D-Glucose (C)
-0.2
-0.3
-0.5
-0.2
-0.4
nitrogen source
L-Glutamic 10 mM (N)
-0.2
-0.5
-0.5
+0.2
-0.5
carbon source
L-Asparagine (C)
-0.6
-0.6
-0.1
-0.3
+0.0
carbon source
Stearic 100 uM (C)
-0.5
-0.5
-0.7
+0.3
-0.2
nitrogen source
L-Glutamine 10 mM (N)
-0.4
-0.5
-0.4
+0.1
-0.3
carbon source
heptadecanoic 250 uM (C)
-0.4
-0.5
-0.4
+0.2
-0.2
carbon source
L-Glutamine (C)
-0.4
-0.4
-0.3
-0.2
+0.4
stress
7H9 with Dimethyl Sulfoxide 1 vol%
-0.7
-0.6
-0.2
+0.1
+0.9
stress
7H9 with Streptomycin 0.178 ug/mL
-0.0
-0.3
+0.3
+0.4
+0.8
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