Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3488 and Rv3489 are separated by 81 nucleotidesRv3489 and Rv3490 overlap by 1 nucleotidesRv3490 and Rv3491 are separated by 151 nucleotidesRv3491 and Rv3492c overlap by 4 nucleotides Rv3488: Rv3488 - Conserved hypothetical protein, at 3,907,667 to 3,907,990 Rv3488 Rv3489: Rv3489 - Unknown protein, at 3,908,072 to 3,908,236 Rv3489 Rv3490: Rv3490 - Alpha, alpha-trehalose-phosphate synthase [UDP-forming] OtsA (trehalose-6-phosphate synthase) (UDP-glucose-glucosephosphate glucosyltransferase) (trehalosephosphate-UDP glucosyltransferase) (trehalose-6-phosphate synthetase) (trehalose-phosphate synthase) (trehalose-phosphate synthetase) (transglucosylase) (trehalosephosphate-UDP glucosyl transferase), at 3,908,236 to 3,909,738 Rv3490 Rv3491: Rv3491 - Unknown protein, at 3,909,890 to 3,910,468 Rv3491 Rv3492c: Rv3492c - Conserved hypothetical Mce associated protein, at 3,910,465 to 3,910,947 Rv3492c
Group Condition Rv3488 Rv3489 Rv3490 Rv3491 Rv3492c
stress 7H9 with Meropenem 9.6 ug/mL -0.4 N.D. N.D. -0.3 -1.6
stress 7H9 with Clofazimine 0.45 ug/mL -0.4 N.D. N.D. -0.7 -0.8
carbon source Glycerol (C) +0.0 N.D. N.D. -0.3 -1.4
stress 7H9 with Clofazimine 0.45 ug/mL -0.3 N.D. N.D. -0.4 -0.9
carbon source L-Lactate 10 mM (C) +0.0 N.D. N.D. +0.1 -1.5
stress 7H9 with Meropenem 9.6 ug/mL -0.0 N.D. N.D. -0.5 -0.8
no stress control no stress control -0.4 N.D. N.D. -0.2 -0.7
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.4 N.D. N.D. -0.4 -0.5
carbon source Glycerol (C) +0.0 N.D. N.D. -0.1 -1.0
nitrogen source L-Glutamic 10 mM (N) -0.2 N.D. N.D. -0.1 -0.7
carbon source heptadecanoic 250 uM (C) -0.2 N.D. N.D. -0.3 -0.6
carbon source butyrate 10 mM (C) +0.3 N.D. N.D. -0.3 -1.0
nitrogen source L-Aspartic Acid 10 mM (N) -0.4 N.D. N.D. -0.2 -0.4
nitrogen source L-Glutamine 10 mM (N) -0.2 N.D. N.D. -0.1 -0.7
stress 7H9 with Ethambutol 0.75 ug/mL -0.5 N.D. N.D. -0.3 -0.2
nitrogen source L-Asparagine 10 mM (N) -0.1 N.D. N.D. -0.1 -0.7
stress 7H9 with Isoniazid 0.025 ug/mL -0.1 N.D. N.D. -0.2 -0.6
carbon source butyrate 10 mM (C) +0.2 N.D. N.D. -0.4 -0.8
no stress control no stress control +0.2 N.D. N.D. -0.2 -0.9
nitrogen source Glycine 10 mM (N) +0.1 N.D. N.D. -0.3 -0.7
nitrogen source Glycine 10 mM (N) +0.3 N.D. N.D. -0.0 -1.1
carbon source casaminos 1 mg/mL (C) -0.2 N.D. N.D. +0.2 -0.7
stress 7H9 with Bedaquiline 0.15 ug/mL +0.2 N.D. N.D. -0.4 -0.5
stress 7H9 with para-aminosalicylic 0.086 ug/mL -0.2 N.D. N.D. +0.2 -0.7
carbon source pyruvate (C) +0.1 N.D. N.D. +0.1 -0.8
carbon source Stearic 100 uM (C) +0.3 N.D. N.D. -0.4 -0.5
carbon source L-Asparagine (C) +0.3 N.D. N.D. -0.2 -0.5
carbon source D-Glucose (C) +0.2 N.D. N.D. +0.3 -0.6
carbon source L-Aspartic Acid (C) +0.5 N.D. N.D. -0.3 -0.3
carbon source Valeric 10 mM (C) +0.5 N.D. N.D. -0.2 -0.3
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