Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3475 and Rv3476c are separated by 279 nucleotidesRv3476c and Rv3477 are separated by 372 nucleotidesRv3477 and Rv3478 are separated by 36 nucleotidesRv3478 and Rv3479 are separated by 212 nucleotides Rv3475: Rv3475 - Possible transposase for insertion element IS6110 [second part], at 3,891,105 to 3,892,091 Rv3475 Rv3476c: Rv3476c - Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter), at 3,892,371 to 3,893,720 Rv3476c Rv3477: Rv3477 - PE family protein PE31, at 3,894,093 to 3,894,389 Rv3477 Rv3478: Rv3478 - PE family protein PPE60, at 3,894,426 to 3,895,607 Rv3478 Rv3479: Rv3479 - Possible transmembrane protein, at 3,895,820 to 3,898,885 Rv3479
Group Condition Rv3475 Rv3476c Rv3477 Rv3478 Rv3479
stress 7H9 with Formaldehyde 0.23 mM N.D. +0.0 -2.6 -1.3 -0.2
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM N.D. +0.0 -1.0 -2.0 -0.1
stress 7H9 with methylglyoxal 1.2 mM N.D. +0.1 -1.8 -1.2 -0.2
pH pH 4.5 N.D. -0.3 -0.7 -1.5 -0.2
pH pH 4.5 N.D. -0.2 -2.1 -0.4 +0.1
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 N.D. -0.2 -1.2 -0.9 -0.2
stress 7H9 with methylglyoxal 1.2 mM N.D. +0.1 -0.9 -1.1 -0.2
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 N.D. +0.2 -1.2 -0.8 -0.2
carbon source propionate (C) N.D. +0.2 -0.8 -1.2 +0.1
stress 7H9 with Doxycycline hyclate 0.0035 mM N.D. +0.0 -0.9 -0.8 +0.1
carbon source L-Lactate 10 mM (C) N.D. +0.0 -0.7 -0.9 +0.1
no stress control no stress control N.D. -0.1 -1.2 +0.3 -0.2
no stress control no stress control N.D. +0.5 -0.5 -0.5 -0.1
stress 7H9 with Sisomicin 0.07 mM N.D. +0.5 -1.2 +0.5 +0.4
stress 7H9 with Cloxacillin 0.0386 mM N.D. +0.1 +0.9 -0.6 -0.1
stress 7H9 with Antimycin A 0.0186 mM N.D. -0.1 +1.1 -0.2 -0.3
stress 7H9 with Chloramphenicol 0.01 mM N.D. -0.1 +1.3 -0.4 -0.1
nitrogen source Urea 10mM (N) N.D. -0.0 +1.0 -0.4 +0.2
stress 7H9 with Sulfamethizole 0.026 mM N.D. -0.1 +0.6 +0.8 +0.2
stress 7H9 with Phenazine ethosulfate 0.0137 mM N.D. +0.0 +1.3 +0.2 -0.1
stress 7H9 with Dicloxacillin 0.0069 mM N.D. -0.2 +1.7 +0.1 +0.1
stress 7H9 with Lomefloxacin 0.0035 mM N.D. +0.1 +1.3 +0.4 -0.0
stress 7H9 with Spectinomycin 0.029 mM N.D. +0.1 +0.8 +0.9 -0.0
stress 7H9 with Dibucaine 0.21 mM N.D. +0.4 +1.1 +0.5 -0.2
stress 7H9 with Dodecyl Sulfate 0.02 vol% N.D. +0.1 +0.7 +0.9 +0.1
stress 7H9 with Ethionamide 0.1 ug/mL N.D. +0.1 +0.8 +0.7 +0.2
carbon source cholesterol 100uM (C) N.D. +0.0 +0.6 +0.9 +0.4
stress 7H9 with Linezolid 0.44 ug/mL N.D. -0.0 +1.5 +0.6 -0.0
stress 7H9 with Sulfamethizole 0.026 mM N.D. +0.2 +1.0 +0.8 +0.1
stress 7H9 with Ethionamide 0.1 ug/mL N.D. -0.2 +1.0 +1.0 +0.5
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