Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3417c and Rv3418c are separated by 94 nucleotidesRv3418c and Rv3419c are separated by 266 nucleotidesRv3419c and Rv3420c overlap by 4 nucleotidesRv3420c and Rv3421c overlap by 4 nucleotides Rv3417c: Rv3417c - 60 kDa chaperonin 1 GroEL1 (protein CPN60-1) (GroEL protein 1), at 3,835,272 to 3,836,891 Rv3417c Rv3418c: Rv3418c - 10 kDa chaperonin GroES (protein CPN10) (protein GroES) (BCG-a heat shock protein) (10 kDa antigen), at 3,836,986 to 3,837,288 Rv3418c Rv3419c: Rv3419c - Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease), at 3,837,555 to 3,838,589 Rv3419c Rv3420c: Rv3420c - Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18), at 3,838,586 to 3,839,062 Rv3420c Rv3421c: Rv3421c - Conserved hypothetical protein, at 3,839,059 to 3,839,694 Rv3421c
Group Condition Rv3417c Rv3418c Rv3419c Rv3420c Rv3421c
no stress control no stress control -0.1 N.D. -2.3 +0.0 N.D.
stress 7H9 with Isoniazid 0.025 ug/mL +0.1 N.D. -1.9 +0.0 N.D.
carbon source D-Glucose (C) +0.0 N.D. -1.6 -0.1 N.D.
no stress control no stress control +0.5 N.D. -1.7 +0.1 N.D.
no stress control no stress control -0.6 N.D. +0.7 -0.7 N.D.
carbon source Palmitic 100 uM (C) +0.3 N.D. -1.6 +0.7 N.D.
carbon source Stearic 100 uM (C) +0.5 N.D. -1.1 +0.1 N.D.
stress 7H9 with Clofazimine 0.45 ug/mL +0.2 N.D. +0.4 -0.9 N.D.
stress 7H9 with Isoniazid 0.025 ug/mL +0.7 N.D. -0.8 -0.1 N.D.
stress 7H9 with Clofazimine 0.45 ug/mL +0.1 N.D. +0.9 -1.1 N.D.
stress 7H9 with Clofazimine 0.072 ug/mL +0.3 N.D. +0.7 -0.7 N.D.
stress 7H9 with Hygromycin B 0.0095 mM +0.8 N.D. -0.4 +0.4 N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL -0.6 N.D. +1.0 +0.3 N.D.
carbon source acetate (C) -0.3 N.D. +1.4 -0.2 N.D.
carbon source D-Lactate 10 mM (C) -0.3 N.D. +0.9 +0.4 N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% +0.9 N.D. -0.5 +0.8 N.D.
no stress control no stress control +0.7 N.D. +0.9 -0.1 N.D.
stress 7H9 with Ethambutol 0.75 ug/mL +0.5 N.D. +1.2 +0.0 N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.1 N.D. +1.3 +0.3 N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.3 N.D. +0.9 +0.5 N.D.
stress 7H9 with Clarithromycin 0.967 ug/mL +0.5 N.D. +1.0 +0.3 N.D.
nitrogen source L-Glutamine 10 mM (N) +0.5 N.D. +1.0 +0.2 N.D.
nitrogen source L-Glutamic 10 mM (N) +0.2 N.D. +1.2 +0.5 N.D.
stress 7H9 with Pretomanid 0.213 ug/mL +0.1 N.D. +1.0 +0.8 N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL +0.3 N.D. +1.1 +0.8 N.D.
stress 7H9 with Sulfamethizole 0.026 mM +0.5 N.D. +1.2 +0.7 N.D.
stress 7H9 with Rifampicin 0.014 ug/mL +0.3 N.D. +1.8 +0.3 N.D.
stress 7H9 with Sulfamethizole 0.026 mM +0.5 N.D. +1.2 +0.8 N.D.
stress 7H9 with Pretomanid 0.213 ug/mL +0.4 N.D. +1.3 +0.9 N.D.
stress 7H9 with Rifampicin 0.014 ug/mL +0.4 N.D. +1.9 +0.5 N.D.
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