Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3407 and Rv3408 overlap by 4 nucleotidesRv3408 and Rv3409c are separated by 32 nucleotidesRv3409c and Rv3410c are separated by 55 nucleotidesRv3410c and Rv3411c are separated by 19 nucleotides Rv3407: Rv3407 - Possible antitoxin VapB47, at 3,826,252 to 3,826,551 Rv3407 Rv3408: Rv3408 - Possible toxin VapC47. Contains PIN domain., at 3,826,548 to 3,826,958 Rv3408 Rv3409c: Rv3409c - Cholesterol oxidase ChoD (cholesterol-O2 oxidoreductase), at 3,826,991 to 3,828,727 Rv3409c Rv3410c: Rv3410c - Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD), at 3,828,783 to 3,829,910 Rv3410c Rv3411c: Rv3411c - Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD), at 3,829,930 to 3,831,519 Rv3411c
Group Condition Rv3407 Rv3408 Rv3409c Rv3410c Rv3411c
no stress control no stress control -0.1 -0.6 -0.2 N.D. N.D.
stress 7H9 with Erythromycin 0.016 mM -0.5 -0.1 +0.1 N.D. N.D.
no stress control no stress control -0.4 -0.3 +0.2 N.D. N.D.
stress 7H9 with Sisomicin 0.07 mM -0.3 +0.2 -0.3 N.D. N.D.
carbon source cholesterol 100uM (C) -0.4 +0.3 -0.2 N.D. N.D.
carbon source oleate 200uM (C) -0.6 +0.4 -0.0 N.D. N.D.
stress 7H9 with Nickel (II) chloride 0.6 mM +0.4 -0.0 -0.5 N.D. N.D.
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 -0.4 +0.2 +0.2 N.D. N.D.
no stress control no stress control -0.1 +0.4 -0.3 N.D. N.D.
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM -0.2 +0.6 -0.3 N.D. N.D.
stress 7H9 with Irgasan 0.065 mM -0.0 -0.2 +0.5 N.D. N.D.
carbon source Palmitic 100 uM (C) +0.5 -0.3 -0.0 N.D. N.D.
nitrogen source L-Asparagine 10 mM (N) -0.2 +0.4 +0.1 N.D. N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL +0.5 +0.3 -0.4 N.D. N.D.
stress 7H9 with Menadione 0.005 mM -0.3 +0.5 +0.1 N.D. N.D.
no stress control no stress control -0.2 +0.5 +0.1 N.D. N.D.
nitrogen source L-Glutamic 10 mM (N) -0.1 +0.6 -0.1 N.D. N.D.
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM +0.2 -0.2 +0.4 N.D. N.D.
stress 7H9 with Tetracycline 0.0058 mM -0.2 +0.5 +0.2 N.D. N.D.
stress 7H9 with Levofloxacin 0.3 ug/mL +0.3 +0.4 -0.2 N.D. N.D.
stress 7H9 with Doxycycline hyclate 0.0035 mM +0.2 +0.4 -0.1 N.D. N.D.
stress 7H9 with copper (II) chloride 0.08 mM -0.2 +0.5 +0.2 N.D. N.D.
stress 7H9 with Pretomanid 0.213 ug/mL +0.8 -0.4 +0.2 N.D. N.D.
stress 7H9 with 2,4-Dinitrophenol 0.1503 mM +0.4 +0.5 -0.3 N.D. N.D.
carbon source heptadecanoic 250 uM (C) +0.3 +0.5 -0.1 N.D. N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.5 +0.4 -0.2 N.D. N.D.
stress 7H9 with Tetrazolium violet 0.065 mM +0.2 +0.4 +0.1 N.D. N.D.
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM +0.4 +0.3 +0.1 N.D. N.D.
carbon source pyruvate (C) +0.3 +0.3 +0.3 N.D. N.D.
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 +0.3 +0.5 +0.1 N.D. N.D.
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