Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3405c and Rv3406 are separated by 61 nucleotidesRv3406 and Rv3407 are separated by 34 nucleotidesRv3407 and Rv3408 overlap by 4 nucleotidesRv3408 and Rv3409c are separated by 32 nucleotides Rv3405c: Rv3405c - Possible transcriptional regulatory protein, at 3,824,702 to 3,825,268 Rv3405c Rv3406: Rv3406 - Probable dioxygenase, at 3,825,330 to 3,826,217 Rv3406 Rv3407: Rv3407 - Possible antitoxin VapB47, at 3,826,252 to 3,826,551 Rv3407 Rv3408: Rv3408 - Possible toxin VapC47. Contains PIN domain., at 3,826,548 to 3,826,958 Rv3408 Rv3409c: Rv3409c - Cholesterol oxidase ChoD (cholesterol-O2 oxidoreductase), at 3,826,991 to 3,828,727 Rv3409c
Group Condition Rv3405c Rv3406 Rv3407 Rv3408 Rv3409c
stress 7H9 with Novobiocin 0.004 mM -2.7 +0.1 -0.5 +0.1 +0.0
stress 7H9 with Levofloxacin 0.3 ug/mL -2.9 +0.0 +0.3 +0.4 -0.2
stress 7H9 with Isoniazid 0.025 ug/mL -1.4 -0.1 -0.1 -0.3 -0.1
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -2.1 +0.1 +0.4 -0.3 -0.0
stress 7H9 with Ethionamide 0.1 ug/mL -1.6 -0.2 -0.2 +0.2 -0.0
stress 7H9 with Novobiocin 0.004 mM -2.5 +0.1 +0.3 +0.2 +0.2
stress 7H9 with 2,4-Dinitrophenol 0.1503 mM -1.4 -0.1 -0.2 +0.2 -0.0
stress 7H9 with Cloxacillin 0.0386 mM -1.7 +0.2 +0.2 +0.2 -0.2
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM -1.0 +0.0 -0.0 -0.4 +0.1
stress 7H9 with nitrite 1.5 mM; pH 5.5 -1.3 +0.1 +0.1 +0.0 -0.1
stress 7H9 with Formaldehyde 0.23 mM -1.2 +0.1 -0.1 -0.2 +0.3
stress 7H9 with nitrate 4 mM -1.5 +0.2 -0.1 +0.2 +0.3
no stress control no stress control -1.4 +0.1 +0.3 +0.1 +0.0
stress 7H9 with Lomefloxacin 0.0035 mM -1.2 -0.2 +0.2 +0.1 +0.2
stress 7H9 with Amikacin di2 ug/mL -1.3 +0.1 -0.1 +0.3 +0.2
stress 7H9 with copper (II) chloride 0.08 mM -1.2 +0.0 -0.2 +0.5 +0.2
no stress control no stress control -0.6 -0.3 -0.2 +0.5 +0.1
stress 7H9 with Lomefloxacin 0.0035 mM -1.0 -0.1 +0.5 +0.2 -0.0
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.8 -0.2 +0.5 -0.0 +0.1
stress 7H9 with Ofloxacin 0.8 ug/mL -0.7 -0.0 +0.5 +0.3 -0.4
stress 7H9 with Phenazine ethosulfate 0.0137 mM -1.2 +0.2 +0.3 +0.2 +0.2
stress 7H9 with 2,4-Dinitrophenol 0.1503 mM -0.7 -0.1 +0.4 +0.5 -0.3
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM -0.5 +0.2 -0.2 +0.6 -0.3
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.6 -0.1 +0.5 +0.4 -0.2
carbon source heptadecanoic 250 uM (C) -0.6 +0.1 +0.3 +0.5 -0.1
no stress control no stress control -0.6 +0.3 +0.4 +0.2 +0.1
carbon source D-Trehalose 10 mM (C) +1.0 -0.1 +0.1 -0.2 -0.2
carbon source D,L-Malic Acid 10 mM (C) +0.9 +0.1 +0.2 +0.1 -0.3
stress 7H9 with Streptomycin 0.178 ug/mL +1.0 -0.3 +0.1 +0.3 -0.1
stress 7H9 with Menadione 0.005 mM +1.1 +0.0 -0.3 +0.5 +0.1
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