Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3377c and Rv3378c are separated by 4 nucleotidesRv3378c and Rv3379c are separated by 8 nucleotidesRv3379c and Rv3380c are separated by 232 nucleotidesRv3380c and Rv3381c overlap by 52 nucleotides Rv3377c: Rv3377c - Halimadienyl diphosphate synthase, at 3,790,848 to 3,792,353 Rv3377c Rv3378c: Rv3378c - Diterpene synthase, at 3,792,358 to 3,793,248 Rv3378c Rv3379c: Rv3379c - Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs2 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS), at 3,793,257 to 3,794,867 Rv3379c Rv3380c: Rv3380c - Probable transposase, at 3,795,100 to 3,796,086 Rv3380c Rv3381c: Rv3381c - Probable transposase for insertion sequence element IS6110 (fragment), at 3,796,035 to 3,796,361 Rv3381c
Group Condition Rv3377c Rv3378c Rv3379c Rv3380c Rv3381c
stress 7H9 with Isoniazid 0.025 ug/mL -1.3 N.D. -0.1 N.D. N.D.
stress 7H9 with Isoniazid 0.025 ug/mL -1.1 N.D. -0.1 N.D. N.D.
stress 7H9 with Amikacin di2 ug/mL +1.0 N.D. +0.1 N.D. N.D.
stress 7H9 with Antimycin A 0.0186 mM +0.8 N.D. +0.3 N.D. N.D.
carbon source D-Trehalose 10 mM (C) +0.9 N.D. +0.3 N.D. N.D.
stress 7H9 with 2,4-Dinitrophenol 0.1503 mM +1.1 N.D. +0.0 N.D. N.D.
nitrogen source Glycine 10 mM (N) +1.0 N.D. +0.1 N.D. N.D.
no stress control no stress control +0.9 N.D. +0.2 N.D. N.D.
no stress control no stress control +1.2 N.D. -0.1 N.D. N.D.
stress 7H9 with Dicloxacillin 0.0069 mM +1.0 N.D. +0.2 N.D. N.D.
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM +1.0 N.D. +0.1 N.D. N.D.
nitrogen source Glycine 10 mM (N) +1.0 N.D. +0.2 N.D. N.D.
stress 7H9 with Hygromycin B 0.0095 mM +1.0 N.D. +0.2 N.D. N.D.
no stress control no stress control +1.0 N.D. +0.3 N.D. N.D.
pH 7H9 pH 5.5 +1.0 N.D. +0.3 N.D. N.D.
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM +1.0 N.D. +0.3 N.D. N.D.
pH pH 5.5 +0.8 N.D. +0.5 N.D. N.D.
nitrogen source Ammonium chloride 10mM (N) +1.2 N.D. +0.2 N.D. N.D.
stress 7H9 with 2,4-Dinitrophenol 0.1503 mM +1.1 N.D. +0.3 N.D. N.D.
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM +1.1 N.D. +0.4 N.D. N.D.
nitrogen source Ammonium chloride 10mM (N) +1.1 N.D. +0.4 N.D. N.D.
pH pH 5.5 +1.3 N.D. +0.3 N.D. N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% +1.3 N.D. +0.4 N.D. N.D.
nitrogen source Urea 10mM (N) +1.4 N.D. +0.5 N.D. N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% +1.4 N.D. +0.5 N.D. N.D.
nitrogen source Urea 10mM (N) +1.6 N.D. +0.4 N.D. N.D.
carbon source L-Lactate 10 mM (C) +1.5 N.D. +0.5 N.D. N.D.
stress 7H9 with Dodecyl Sulfate 0.02 vol% +1.5 N.D. +0.6 N.D. N.D.
carbon source L-Lactate 10 mM (C) +1.9 N.D. +0.5 N.D. N.D.
stress 7H9 with Dodecyl Sulfate 0.02 vol% +1.9 N.D. +0.5 N.D. N.D.
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