Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3327 and Rv3328c overlap by 68 nucleotidesRv3328c and Rv3329 are separated by 59 nucleotidesRv3329 and Rv3330 are separated by 68 nucleotidesRv3330 and Rv3331 are separated by 95 nucleotides Rv3327: Rv3327 - Probable transposase fusion protein, at 3,711,749 to 3,713,461 Rv3327 Rv3328c: Rv3328c - Probable alternative RNA polymerase sigma factor (fragment) SigJ, at 3,713,394 to 3,714,332 Rv3328c Rv3329: Rv3329 - Probable aminotransferase, at 3,714,392 to 3,715,708 Rv3329 Rv3330: Rv3330 - Probable penicillin-binding protein DacB1 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (serine-type D-ala-D-ala carboxypeptidase) (D-amino acid hydrolase), at 3,715,777 to 3,716,994 Rv3330 Rv3331: Rv3331 - Probable sugar-transport integral membrane protein SugI, at 3,717,090 to 3,718,598 Rv3331
Group Condition Rv3327 Rv3328c Rv3329 Rv3330 Rv3331
carbon source D-Glucose (C) -0.1 -0.1 -0.0 -0.1 -3.5
carbon source D-Glucose (C) +0.1 +0.0 -0.1 +0.1 -3.1
stress 7H9 with Menadione 0.005 mM -0.1 -0.9 -0.1 -0.4 -0.5
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM -0.2 -0.2 -0.4 -0.5 -0.4
no stress control no stress control +0.2 -0.9 -0.2 +0.0 -0.9
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM -0.0 -0.7 -0.3 -0.5 -0.2
stress 7H9 with Irgasan 0.065 mM +0.0 -1.0 -0.1 -0.2 -0.2
nitrogen source L-Glutamic 10 mM (N) +0.2 -0.8 -0.5 +0.2 +0.2
stress 7H9 with Benzethonium chloride 0.068 mM +0.2 -0.9 -0.2 -0.0 +0.4
no stress control no stress control -0.2 +0.6 +0.2 -0.2 -0.5
stress 7H9 with Tetracycline 0.0058 mM -0.2 -0.5 -0.2 -0.1 +0.9
carbon source oleate 200uM (C) -0.0 -0.8 -0.1 -0.2 +1.1
stress 7H9 with Lomefloxacin 0.0035 mM +0.1 -1.1 +0.4 +0.1 +0.5
stress 7H9 with copper (II) chloride 0.08 mM -0.7 +0.3 -0.1 -0.1 +0.8
stress 7H9 with EDTA (disodium salt) 0.2 mM +0.3 -0.4 -0.4 +0.3 +0.6
stress 7H9 with Rifampicin 0.014 ug/mL +0.1 +0.2 -0.2 -0.6 +0.9
stress 7H9 with Cumene hydroperoxide 0.05 mM -0.1 -0.3 +0.1 -0.3 +1.0
stress 7H9 with Norfloxacin 0.125 mM +0.1 -0.6 -0.1 +0.3 +0.8
stress 7H9 with Rifampicin 0.014 ug/mL +0.1 +0.6 -0.1 -0.7 +0.9
stress 7H9 with Clarithromycin 0.967 ug/mL +0.1 -0.4 +0.2 -0.1 +1.1
stress 7H9 with Meropenem 9.6 ug/mL -0.3 +1.1 -0.1 -0.4 +0.8
stress 7H9 with Linezolid 0.44 ug/mL +0.0 +0.7 -0.1 -0.2 +0.8
carbon source oleate 200uM (C) -0.0 +0.1 -0.1 -0.1 +1.4
carbon source Stearic 100 uM (C) -0.2 +0.4 -0.1 +0.3 +0.8
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.4 +0.0 +0.5 -0.2 +0.7
stress 7H9 with Clarithromycin 0.967 ug/mL +0.3 -0.3 +0.3 +0.1 +1.2
nitrogen source Ammonium chloride 10mM (N) -0.1 +1.2 +0.1 +0.0 +0.4
stress 7H9 with Sutezolid 0.12 ug/mL +0.2 +0.6 +0.1 +0.4 +0.5
stress 7H9 with Ethambutol 0.75 ug/mL -0.1 +0.6 +0.1 +0.1 +1.0
stress 7H9 with Pretomanid 0.213 ug/mL +0.1 +0.3 +0.2 +0.2 +1.2
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