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Protein
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Fitness for 5 genes in
Mycobacterium tuberculosis H37Rv
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Top 30 experiments (either direction), sorted by average fitness
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500 nt
Rv3327 and Rv3328c overlap by 68 nucleotides
Rv3328c and Rv3329 are separated by 59 nucleotides
Rv3329 and Rv3330 are separated by 68 nucleotides
Rv3330 and Rv3331 are separated by 95 nucleotides
Rv3327: Rv3327 - Probable transposase fusion protein, at 3,711,749 to 3,713,461
Rv3327
Rv3328c: Rv3328c - Probable alternative RNA polymerase sigma factor (fragment) SigJ, at 3,713,394 to 3,714,332
Rv3328c
Rv3329: Rv3329 - Probable aminotransferase, at 3,714,392 to 3,715,708
Rv3329
Rv3330: Rv3330 - Probable penicillin-binding protein DacB1 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (serine-type D-ala-D-ala carboxypeptidase) (D-amino acid hydrolase), at 3,715,777 to 3,716,994
Rv3330
Rv3331: Rv3331 - Probable sugar-transport integral membrane protein SugI, at 3,717,090 to 3,718,598
Rv3331
Group
Condition
Rv3327
Rv3328c
Rv3329
Rv3330
Rv3331
carbon source
D-Glucose (C)
-0.1
-0.1
-0.0
-0.1
-3.5
carbon source
D-Glucose (C)
+0.1
+0.0
-0.1
+0.1
-3.1
stress
7H9 with Menadione 0.005 mM
-0.1
-0.9
-0.1
-0.4
-0.5
stress
7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM
-0.2
-0.2
-0.4
-0.5
-0.4
no stress control
no stress control
+0.2
-0.9
-0.2
+0.0
-0.9
stress
7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM
-0.0
-0.7
-0.3
-0.5
-0.2
stress
7H9 with Irgasan 0.065 mM
+0.0
-1.0
-0.1
-0.2
-0.2
nitrogen source
L-Glutamic 10 mM (N)
+0.2
-0.8
-0.5
+0.2
+0.2
stress
7H9 with Benzethonium chloride 0.068 mM
+0.2
-0.9
-0.2
-0.0
+0.4
no stress control
no stress control
-0.2
+0.6
+0.2
-0.2
-0.5
stress
7H9 with Tetracycline 0.0058 mM
-0.2
-0.5
-0.2
-0.1
+0.9
carbon source
oleate 200uM (C)
-0.0
-0.8
-0.1
-0.2
+1.1
stress
7H9 with Lomefloxacin 0.0035 mM
+0.1
-1.1
+0.4
+0.1
+0.5
stress
7H9 with copper (II) chloride 0.08 mM
-0.7
+0.3
-0.1
-0.1
+0.8
stress
7H9 with EDTA (disodium salt) 0.2 mM
+0.3
-0.4
-0.4
+0.3
+0.6
stress
7H9 with Rifampicin 0.014 ug/mL
+0.1
+0.2
-0.2
-0.6
+0.9
stress
7H9 with Cumene hydroperoxide 0.05 mM
-0.1
-0.3
+0.1
-0.3
+1.0
stress
7H9 with Norfloxacin 0.125 mM
+0.1
-0.6
-0.1
+0.3
+0.8
stress
7H9 with Rifampicin 0.014 ug/mL
+0.1
+0.6
-0.1
-0.7
+0.9
stress
7H9 with Clarithromycin 0.967 ug/mL
+0.1
-0.4
+0.2
-0.1
+1.1
stress
7H9 with Meropenem 9.6 ug/mL
-0.3
+1.1
-0.1
-0.4
+0.8
stress
7H9 with Linezolid 0.44 ug/mL
+0.0
+0.7
-0.1
-0.2
+0.8
carbon source
oleate 200uM (C)
-0.0
+0.1
-0.1
-0.1
+1.4
carbon source
Stearic 100 uM (C)
-0.2
+0.4
-0.1
+0.3
+0.8
stress
7H9 with Moxifloxacin 0.121 ug/mL
+0.4
+0.0
+0.5
-0.2
+0.7
stress
7H9 with Clarithromycin 0.967 ug/mL
+0.3
-0.3
+0.3
+0.1
+1.2
nitrogen source
Ammonium chloride 10mM (N)
-0.1
+1.2
+0.1
+0.0
+0.4
stress
7H9 with Sutezolid 0.12 ug/mL
+0.2
+0.6
+0.1
+0.4
+0.5
stress
7H9 with Ethambutol 0.75 ug/mL
-0.1
+0.6
+0.1
+0.1
+1.0
stress
7H9 with Pretomanid 0.213 ug/mL
+0.1
+0.3
+0.2
+0.2
+1.2
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