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Protein
Homologs
Fitness for 5 genes in
Mycobacterium tuberculosis H37Rv
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Number of genes on each side:
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Top 30 experiments (either direction), sorted by average fitness
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500 nt
Rv3303c and Rv3304 are separated by 202 nucleotides
Rv3304 and Rv3305c are separated by 18 nucleotides
Rv3305c and Rv3306c overlap by 4 nucleotides
Rv3306c and Rv3307 are separated by 64 nucleotides
Rv3303c: Rv3303c - NAD(P)H quinone reductase LpdA, at 3,689,457 to 3,690,938
Rv3303c
Rv3304: Rv3304 - Conserved protein, at 3,691,141 to 3,691,620
Rv3304
Rv3305c: Rv3305c - Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase), at 3,691,639 to 3,692,808
Rv3305c
Rv3306c: Rv3306c - Probable amidohydrolase AmiB1 (aminohydrolase), at 3,692,805 to 3,693,989
Rv3306c
Rv3307: Rv3307 - Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP), at 3,694,054 to 3,694,860
Rv3307
Group
Condition
Rv3303c
Rv3304
Rv3305c
Rv3306c
Rv3307
stress
7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM
-0.0
-0.2
+0.3
-5.1
-0.0
stress
7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM
-0.3
-0.3
-1.1
-3.2
+0.2
stress
7H9 with Hydrogen peroxide 3.97 mM
-0.3
-0.3
-1.3
-2.1
-0.1
carbon source
heptadecanoic 250 uM (C)
+0.0
-0.4
-0.5
-2.8
+0.1
stress
7H9 with Linezolid 0.44 ug/mL
-0.1
-0.2
-1.2
-1.7
-0.3
stress
7H9 with Cloxacillin 0.0386 mM
+0.0
-0.1
-0.2
-2.8
-0.1
stress
7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM
+0.4
-1.4
+0.1
-2.1
+0.1
stress
7H9 with Tetrazolium violet 0.065 mM
-0.2
-0.3
-0.2
-2.1
-0.1
stress
7H9 with Chlorhexidine diacetate salt 0.0021 mM
-0.3
-0.0
+0.3
-2.6
-0.1
stress
7H9 with methylglyoxal 1.2 mM
+0.1
-0.4
+0.1
-2.4
-0.1
stress
7H9 with nitrate 4 mM
-0.3
-0.5
+0.3
-2.2
-0.1
stress
7H9 with Rifampicin 0.00045 ug/mL
-0.0
-0.8
+0.4
-2.2
+0.0
no stress control
no stress control
-0.7
+0.3
-0.3
-1.3
-0.3
stress
7H9 with Ciprofloxacin Hydrochloride 0.001 mM
-0.1
-0.4
-0.0
-2.0
+0.3
stress
7H9 with Bedaquiline 0.15 ug/mL
-1.6
-0.4
+0.4
-0.7
-0.0
carbon source
Stearic 100 uM (C)
-0.2
+0.6
-0.2
-2.2
-0.1
pH
pH 4.5
-0.8
-1.8
+0.8
+0.1
-0.1
stress
7H9 with 2,4-Dinitrophenol 0.1503 mM
-0.3
-0.1
+0.8
-1.6
+0.1
stress
7H9 with Hygromycin B 0.0095 mM
+0.1
-0.6
+0.9
-1.2
-0.3
pH
pH 4.5
-0.8
-1.6
+0.7
+1.1
-0.3
stress
7H9 with copper (II) chloride 0.08 mM
-0.0
+0.2
+0.9
-2.1
+0.1
no stress control
no stress control
-0.6
+0.5
+0.6
-1.2
-0.1
stress
7H9 with nitrite 2.5 mM
-0.5
+0.2
+0.8
-1.3
+0.1
stress
7H9 with Ciprofloxacin Hydrochloride 0.0012 mM
-0.1
-0.7
-0.7
+1.2
-0.3
stress
7H9 with copper (II) chloride 0.08 mM
-0.3
-0.1
+1.3
-1.2
-0.1
stress
7H9 with Cetrimonium bromide 0.015 vol%
+0.1
+0.5
-1.6
+0.7
+0.2
stress
7H9 with Pyrazinamide 50 ug/mL; pH 5.5
+0.1
-1.5
+0.3
+1.2
-0.2
stress
7H9 with Isoniazid 0.025 ug/mL
-0.5
+0.4
-0.4
+1.4
-0.5
stress
7H9 with Sisomicin 0.07 mM
+0.3
-0.8
+1.4
-0.6
+0.2
stress
7H9 with Isoniazid 0.025 ug/mL
-0.4
+0.8
-0.3
+1.4
-0.5
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