Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3290c and Rv3291c are separated by 50 nucleotidesRv3291c and Rv3292 are separated by 30 nucleotidesRv3292 and Rv3293 are separated by 26 nucleotidesRv3293 and Rv3294c are separated by 99 nucleotides Rv3290c: Rv3290c - Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase), at 3,670,445 to 3,671,794 Rv3290c Rv3291c: Rv3291c - Probable transcriptional regulatory protein LrpA (Lrp/AsnC-family), at 3,671,845 to 3,672,297 Rv3291c Rv3292: Rv3292 - Conserved hypothetical protein, at 3,672,328 to 3,673,575 Rv3292 Rv3293: Rv3293 - Probable piperideine-6-carboxilic acid dehydrogenase Pcd (piperideine-6-carboxylate dehydrogenase), at 3,673,602 to 3,675,086 Rv3293 Rv3294c: Rv3294c - Conserved hypothetical protein, at 3,675,186 to 3,675,995 Rv3294c
Group Condition Rv3290c Rv3291c Rv3292 Rv3293 Rv3294c
nitrogen source L-Asparagine 10 mM (N) -0.3 -0.3 -0.3 -0.1 -0.0
stress 7H9 with para-aminosalicylic 0.086 ug/mL -0.2 -0.4 -0.2 -0.2 +0.0
stress 7H9 with Isoniazid 0.025 ug/mL -0.3 -0.4 -0.4 -0.0 +0.1
stress 7H9 with Levofloxacin 0.3 ug/mL -0.2 -0.1 -0.5 -0.3 +0.3
stress 7H9 with Isoniazid 0.025 ug/mL -0.4 -0.0 -0.7 -0.2 +0.3
carbon source L-Lactate 10 mM (C) -0.2 -1.0 +0.0 +0.3 +0.1
stress 7H9 with Streptomycin 0.178 ug/mL -0.1 -0.4 -0.4 -0.1 +0.2
stress 7H9 with Meropenem 9.6 ug/mL -0.1 -0.3 -0.3 -0.2 +0.1
stress 7H9 with Ethionamide 0.1 ug/mL -0.4 -0.2 -0.4 -0.1 +0.3
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.1 -0.2 -0.6 -0.0 +0.1
stress 7H9 with Hygromycin B 0.0095 mM +0.1 -0.5 -0.3 -0.2 +0.1
stress 7H9 with Meropenem 9.6 ug/mL -0.2 -0.3 -0.1 -0.3 +0.2
no stress control no stress control -0.1 -0.4 -0.2 -0.2 +0.2
stress 7H9 with Delamanid 0.236 ug/mL -0.2 -0.2 -0.3 -0.1 +0.1
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.1 -0.4 -0.1 -0.1 +0.1
stress 7H9 with Rifampicin 0.014 ug/mL -0.1 -0.3 -0.2 -0.3 +0.2
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.0 -0.3 -0.5 +0.2 +0.0
stress 7H9 with Rifampicin 0.00045 ug/mL -0.1 -0.2 -0.2 -0.2 +0.2
no stress control no stress control -0.3 +0.4 -0.5 -0.3 +0.3
stress 7H9 with Rifampicin 0.014 ug/mL -0.2 -0.4 -0.1 +0.1 +0.2
carbon source D-Trehalose 10 mM (C) -0.2 -0.4 -0.0 +0.2 +0.1
stress 7H9 with Clarithromycin 0.967 ug/mL +0.0 -0.4 -0.3 +0.2 +0.2
carbon source L-Glutamine (C) -0.1 -0.5 +0.1 +0.1 +0.2
carbon source L-Glutamine (C) -0.1 -0.3 -0.1 +0.3 -0.0
nitrogen source L-Glutamic 10 mM (N) -0.3 +0.0 -0.3 +0.3 +0.0
carbon source L-Lactate 10 mM (C) -0.1 -0.2 -0.2 +0.2 +0.2
carbon source propionate (C) -0.1 -0.3 -0.1 +0.1 +0.3
carbon source Valeric 10 mM (C) +0.2 -0.3 -0.0 +0.3 -0.1
carbon source Palmitic 100 uM (C) +0.3 -0.2 +0.2 +0.1 +0.1
carbon source pyruvate (C) +0.1 -0.3 +0.1 +0.2 +0.5
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