Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3285 and Rv3286c are separated by 9 nucleotidesRv3286c and Rv3287c overlap by 4 nucleotidesRv3287c and Rv3288c are separated by 197 nucleotidesRv3288c and Rv3289c are separated by 34 nucleotides Rv3285: Rv3285 - Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (alpha chain) AccA3: biotin carboxylase + biotin carboxyl carrier protein (BCCP), at 3,666,357 to 3,668,159 Rv3285 Rv3286c: Rv3286c - Alternative RNA polymerase sigma factor SigF, at 3,668,169 to 3,668,954 Rv3286c Rv3287c: Rv3287c - Anti-sigma factor RsbW (sigma negative effector), at 3,668,951 to 3,669,388 Rv3287c Rv3288c: Rv3288c - Putative protein UsfY, at 3,669,586 to 3,669,999 Rv3288c Rv3289c: Rv3289c - Possible transmembrane protein, at 3,670,034 to 3,670,411 Rv3289c
Group Condition Rv3285 Rv3286c Rv3287c Rv3288c Rv3289c
stress 7H9 with Dicloxacillin 0.0069 mM N.D. -0.5 -1.2 -0.3 -0.5
stress 7H9 with Ethionamide 0.1 ug/mL N.D. -0.1 -1.7 +0.2 -0.3
stress 7H9 with nitrate 4 mM N.D. -0.1 -1.7 -0.0 -0.1
stress 7H9 with Rifampicin 0.014 ug/mL N.D. +0.3 -1.2 -0.4 -0.6
nitrogen source L-Glutamic 10 mM (N) N.D. -0.3 -0.4 -0.4 -0.7
stress 7H9 with Spectinomycin 0.029 mM N.D. -0.4 -0.6 -0.1 -0.7
pH 7H9 pH 5.5 N.D. -0.4 -1.2 +0.1 -0.4
stress 7H9 with Nickel (II) chloride 0.6 mM N.D. -0.0 -1.4 -0.2 -0.2
carbon source L-Aspartic Acid (C) N.D. -0.3 -1.5 -0.0 +0.0
stress 7H9 with Isoniazid 0.025 ug/mL N.D. -1.0 -1.0 +0.2 +0.1
stress 7H9 with Delamanid 0.236 ug/mL N.D. -0.0 -1.7 -0.2 +0.1
pH pH 5.5 N.D. +0.1 -1.5 -0.0 -0.3
nitrogen source L-Valine 10 mM (N) N.D. +0.2 -1.4 -0.1 -0.1
stress 7H9 with Clarithromycin 0.967 ug/mL N.D. +0.2 -1.4 -0.1 -0.0
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM N.D. +0.4 -0.9 -0.3 -0.2
stress 7H9 with Nickel (II) chloride 0.6 mM N.D. +0.8 -0.8 -0.1 -0.5
stress 7H9 with Ramoplanin 0.009 mM N.D. -0.7 +0.8 -0.1 -0.2
stress 7H9 with Benzethonium chloride 0.068 mM N.D. +0.9 -0.5 -0.1 -0.5
carbon source cholesterol 100uM (C) N.D. -0.8 +0.8 -0.3 +0.3
no stress control no stress control N.D. -1.0 +1.0 -0.1 +0.1
stress 7H9 with Cumene hydroperoxide 0.05 mM N.D. -0.5 +1.0 -0.4 -0.1
pH pH 4.5 N.D. -0.4 +1.5 -0.4 -0.4
stress 7H9 with Formaldehyde 0.23 mM N.D. -0.0 +1.2 -0.3 -0.3
stress 7H9 with Pretomanid 0.213 ug/mL N.D. -0.3 +1.5 -0.2 -0.2
stress 7H9 with EDTA (disodium salt) 0.2 mM N.D. -0.4 +1.2 -0.1 +0.1
no stress control no stress control N.D. +1.1 +0.5 -0.2 +0.0
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM N.D. +0.3 +1.5 -0.2 -0.2
pH pH 4.5 N.D. +0.0 +2.2 +0.1 -0.7
nitrogen source Ammonium chloride 10mM (N) N.D. +0.8 +0.5 +0.4 -0.1
stress 7H9 with Hydrogen peroxide 3.97 mM N.D. +0.2 +1.1 +0.1 +0.4
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