Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3254 and Rv3255c overlap by 23 nucleotidesRv3255c and Rv3256c are separated by 7 nucleotidesRv3256c and Rv3257c overlap by 4 nucleotidesRv3257c and Rv3258c are separated by 101 nucleotides Rv3254: Rv3254 - Conserved hypothetical protein, at 3,633,675 to 3,635,063 Rv3254 Rv3255c: Rv3255c - Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (phosphohexomutase), at 3,635,041 to 3,636,267 Rv3255c Rv3256c: Rv3256c - Conserved protein, at 3,636,275 to 3,637,315 Rv3256c Rv3257c: Rv3257c - Probable phosphomannomutase PmmA (PMM) (phosphomannose mutase), at 3,637,312 to 3,638,709 Rv3257c Rv3258c: Rv3258c - Conserved hypothetical protein, at 3,638,811 to 3,639,302 Rv3258c
Group Condition Rv3254 Rv3255c Rv3256c Rv3257c Rv3258c
carbon source acetate (C) -0.1 N.D. -1.0 N.D. N.D.
carbon source D-Glucose (C) +0.0 N.D. -1.0 N.D. N.D.
carbon source acetate (C) -0.1 N.D. -0.9 N.D. N.D.
nitrogen source L-Serine 10 mM (N) -0.2 N.D. -0.8 N.D. N.D.
carbon source Glycerol (C) +0.1 N.D. -0.9 N.D. N.D.
stress 7H9 with Clofazimine 0.45 ug/mL +0.0 N.D. -0.7 N.D. N.D.
carbon source D-Glucose (C) +0.1 N.D. -0.7 N.D. N.D.
nitrogen source L-Asparagine 10 mM (N) +0.2 N.D. -0.5 N.D. N.D.
nitrogen source L-Glutamic 10 mM (N) -0.1 N.D. +0.5 N.D. N.D.
stress 7H9 with Hygromycin B 0.0095 mM -0.2 N.D. +0.7 N.D. N.D.
carbon source D-Lactate 10 mM (C) -0.0 N.D. +0.6 N.D. N.D.
stress 7H9 with Linezolid 0.44 ug/mL +0.4 N.D. +0.3 N.D. N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.0 N.D. +0.7 N.D. N.D.
no stress control no stress control +0.1 N.D. +0.6 N.D. N.D.
carbon source D,L-Malic Acid 10 mM (C) -0.1 N.D. +0.8 N.D. N.D.
carbon source casaminos 1 mg/mL (C) -0.0 N.D. +0.7 N.D. N.D.
stress 7H9 with Streptomycin 0.178 ug/mL +0.2 N.D. +0.5 N.D. N.D.
carbon source D,L-Malic Acid 10 mM (C) -0.2 N.D. +0.9 N.D. N.D.
stress 7H9 with Pretomanid 0.213 ug/mL +0.1 N.D. +0.6 N.D. N.D.
stress 7H9 with Rifampicin 0.014 ug/mL +0.1 N.D. +0.6 N.D. N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL +0.3 N.D. +0.4 N.D. N.D.
carbon source Valeric 10 mM (C) +0.2 N.D. +0.6 N.D. N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL +0.5 N.D. +0.4 N.D. N.D.
nitrogen source L-Valine 10 mM (N) +0.4 N.D. +0.5 N.D. N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.3 N.D. +0.7 N.D. N.D.
stress 7H9 with Sulfaquinoxaline 0.097 mM +0.2 N.D. +0.7 N.D. N.D.
stress 7H9 with Pretomanid 0.213 ug/mL +0.3 N.D. +0.8 N.D. N.D.
stress 7H9 with Sulfamethizole 0.026 mM +0.0 N.D. +1.1 N.D. N.D.
stress 7H9 with Sulfamethizole 0.026 mM -0.1 N.D. +1.3 N.D. N.D.
stress 7H9 with Bedaquiline 0.15 ug/mL +0.1 N.D. +1.7 N.D. N.D.
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