Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3224B and Rv3225c overlap by 4 nucleotidesRv3225c and Rv3226c are separated by 123 nucleotidesRv3226c and Rv3227 are separated by 54 nucleotidesRv3227 and Rv3228 overlap by 4 nucleotides Rv3224B: Rv3224B - Conserved hypothetical protein, at 3,600,801 to 3,601,019 Rv3224B Rv3225c: Rv3225c - GCN5-related N-acetyltransferase, phosphorylase, at 3,601,016 to 3,602,440 Rv3225c Rv3226c: Rv3226c - Conserved hypothetical protein, at 3,602,564 to 3,603,322 Rv3226c Rv3227: Rv3227 - 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS), at 3,603,377 to 3,604,729 Rv3227 Rv3228: Rv3228 - Conserved hypothetical protein, at 3,604,726 to 3,605,718 Rv3228
Group Condition Rv3224B Rv3225c Rv3226c Rv3227 Rv3228
stress 7H9 with Phenazine methosulfate 0.0054 mM N.D. -0.4 +0.2 N.D. N.D.
stress 7H9 with Ethionamide 0.1 ug/mL N.D. +0.2 -0.4 N.D. N.D.
stress 7H9 with nitrite 5 mM N.D. +0.2 -0.4 N.D. N.D.
no stress control no stress control N.D. -0.4 +0.3 N.D. N.D.
nitrogen source L-Valine 10 mM (N) N.D. -0.3 +0.2 N.D. N.D.
stress 7H9 with Nickel (II) chloride 0.6 mM N.D. +0.4 -0.3 N.D. N.D.
stress 7H9 with nitrite 3 mM; pH 5.5 N.D. -0.3 +0.4 N.D. N.D.
no stress control no stress control N.D. -0.2 +0.3 N.D. N.D.
no stress control no stress control N.D. -0.2 +0.4 N.D. N.D.
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 N.D. -0.2 +0.4 N.D. N.D.
stress 7H9 with Dibucaine 0.21 mM N.D. -0.2 +0.4 N.D. N.D.
stress 7H9 with Cloxacillin 0.0386 mM N.D. -0.2 +0.4 N.D. N.D.
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM N.D. -0.3 +0.5 N.D. N.D.
stress 7H9 with Doxycycline hyclate 0.0035 mM N.D. -0.2 +0.4 N.D. N.D.
no stress control no stress control N.D. -0.4 +0.6 N.D. N.D.
no stress control no stress control N.D. -0.1 +0.4 N.D. N.D.
stress 7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM N.D. -0.1 +0.4 N.D. N.D.
stress 7H9 with nitrite 1.5 mM; pH 5.5 N.D. -0.2 +0.5 N.D. N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% N.D. -0.2 +0.6 N.D. N.D.
stress 7H9 with Pretomanid 0.213 ug/mL N.D. -0.1 +0.5 N.D. N.D.
stress 7H9 with Vancomycin Hydrochloride from Streptomyces orientalis 0.012 mM N.D. +0.1 +0.5 N.D. N.D.
stress 7H9 with Meropenem 9.6 ug/mL N.D. +0.3 +0.3 N.D. N.D.
stress 7H9 with Geneticin G418 0.35 mM N.D. +0.3 +0.3 N.D. N.D.
stress 7H9 with Zinc Pyrithione 0.00072 mM N.D. +0.2 +0.4 N.D. N.D.
nitrogen source Ammonium chloride 10mM (N) N.D. +0.3 +0.3 N.D. N.D.
stress 7H9 with Clofazimine 0.45 ug/mL N.D. +0.3 +0.3 N.D. N.D.
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM N.D. +0.0 +0.7 N.D. N.D.
stress 7H9 with Linezolid 0.3 ug/mL N.D. +0.0 +0.8 N.D. N.D.
stress 7H9 with Rifampicin 0.014 ug/mL N.D. +0.4 +0.4 N.D. N.D.
stress 7H9 with Antimycin A 0.0186 mM N.D. -0.1 +1.0 N.D. N.D.
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