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Fitness for 5 genes in
Mycobacterium tuberculosis H37Rv
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Top 30 experiments (either direction), sorted by average fitness
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500 nt
Rv3161c and Rv3162c are separated by 69 nucleotides
Rv3162c and Rv3163c overlap by 4 nucleotides
Rv3163c and Rv3164c are separated by 29 nucleotides
Rv3164c and Rv3165c are separated by 7 nucleotides
Rv3161c: Rv3161c - Possible dioxygenase, at 3,529,990 to 3,531,138
Rv3161c
Rv3162c: Rv3162c - Possible integral membrane protein, at 3,531,208 to 3,531,645
Rv3162c
Rv3163c: Rv3163c - Possible conserved secreted protein, at 3,531,642 to 3,532,913
Rv3163c
Rv3164c: Rv3164c - Probable methanol dehydrogenase transcriptional regulatory protein MoxR3, at 3,532,943 to 3,533,905
Rv3164c
Rv3165c: Rv3165c - Unknown protein, at 3,533,913 to 3,534,395
Rv3165c
Group
Condition
Rv3161c
Rv3162c
Rv3163c
Rv3164c
Rv3165c
no stress control
no stress control
-0.4
-1.0
-0.2
-0.1
-0.5
nitrogen source
L-Glutamine 10 mM (N)
-0.1
-2.0
+0.3
-0.2
+0.2
stress
7H9 with para-aminosalicylic 0.086 ug/mL
-0.1
-1.0
+0.2
-0.5
-0.4
stress
7H9 with Meropenem 9.6 ug/mL
+0.6
-2.5
-0.2
+0.1
+0.3
stress
7H9 with Rifampicin 0.00045 ug/mL
-0.3
-1.2
-0.0
+0.2
+0.4
nitrogen source
Glycine 10 mM (N)
-0.4
-0.2
+0.2
+0.3
-0.8
stress
7H9 with Levofloxacin 0.3 ug/mL
-0.1
+0.9
-0.2
-0.7
-0.9
stress
7H9 with Clofazimine 0.45 ug/mL
+0.0
-0.6
+0.2
+0.5
-1.0
stress
7H9 with Rifampicin 0.014 ug/mL
-0.3
-1.3
+0.4
+0.0
+0.3
stress
7H9 with Isoniazid 0.025 ug/mL
-0.1
+0.8
+0.2
-0.8
-0.9
nitrogen source
L-Glutamic 10 mM (N)
-0.4
-0.7
+0.6
+0.2
-0.4
stress
7H9 with Rifampicin 0.014 ug/mL
-0.1
-1.3
+0.1
+0.3
+0.3
nitrogen source
L-Valine 10 mM (N)
-0.3
-0.3
-0.2
+1.0
-0.9
nitrogen source
Glycine 10 mM (N)
+0.2
-1.4
+0.2
+0.7
+0.0
carbon source
Palmitic 100 uM (C)
+0.8
-0.8
-0.2
-0.0
+0.3
stress
7H9 with Isoniazid 0.025 ug/mL
+0.2
+0.8
-0.3
-1.0
+0.2
carbon source
D-Trehalose 10 mM (C)
-0.3
+0.5
+0.3
-0.7
+0.4
stress
7H9 with Clofazimine 0.072 ug/mL
-0.3
-0.6
+0.5
+0.3
+0.3
carbon source
Stearic 100 uM (C)
+0.5
-0.9
+0.0
-0.1
+0.7
stress
7H9 with Ethionamide 0.1 ug/mL
+0.1
+0.7
+0.4
-0.2
-0.7
carbon source
Stearic 100 uM (C)
-0.1
-0.9
+0.0
+0.4
+0.8
carbon source
D-Trehalose 10 mM (C)
+0.0
+1.2
+0.1
-0.3
-0.5
stress
7H9 with Pretomanid 0.213 ug/mL
-0.0
-0.7
+0.4
+0.3
+0.7
nitrogen source
L-Alanine 10 mM (N)
+0.2
-0.5
-0.2
+1.0
+0.3
nitrogen source
L-Glutamic 10 mM (N)
+0.1
+0.4
+0.4
+0.7
-0.8
no stress control
no stress control
-0.2
+1.2
+0.3
-0.5
-0.0
stress
7H9 with Ofloxacin 0.8 ug/mL
+0.0
+0.9
+0.4
-0.6
+0.1
stress
7H9 with Rifampicin 0.00045 ug/mL
+0.1
-0.5
+0.5
+0.3
+0.6
nitrogen source
L-Glutamine 10 mM (N)
-0.5
+0.2
+0.0
+1.2
+0.1
carbon source
D,L-Malic Acid 10 mM (C)
-0.1
+0.9
+0.4
-0.3
+0.4
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