Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3045 and Rv3046c overlap by 12 nucleotidesRv3046c and Rv3047c are separated by 333 nucleotidesRv3047c and Rv3048c are separated by 97 nucleotidesRv3048c and Rv3049c are separated by 130 nucleotides Rv3045: Rv3045 - Probable NADP-dependent alcohol dehydrogenase AdhC, at 3,406,285 to 3,407,325 Rv3045 Rv3046c: Rv3046c - Conserved protein, at 3,407,314 to 3,407,688 Rv3046c Rv3047c: Rv3047c - Hypothetical protein, at 3,408,022 to 3,408,306 Rv3047c Rv3048c: Rv3048c - Ribonucleoside-diphosphate reductase (beta chain) NrdF2 (ribonucleotide reductase small subunit) (R2F protein), at 3,408,404 to 3,409,378 Rv3048c Rv3049c: Rv3049c - Probable monooxygenase, at 3,409,509 to 3,411,083 Rv3049c
Group Condition Rv3045 Rv3046c Rv3047c Rv3048c Rv3049c
stress 7H9 with Isoniazid 0.025 ug/mL -0.8 -2.8 +0.1 N.D. +0.1
stress 7H9 with Clarithromycin 0.967 ug/mL -0.7 -1.9 -0.2 N.D. -0.0
carbon source L-Lactate 10 mM (C) -1.2 -1.0 -0.1 N.D. +0.0
stress 7H9 with Rifampicin 0.00045 ug/mL -0.6 -1.5 -0.1 N.D. +0.1
no stress control no stress control -0.9 -1.0 -0.0 N.D. +0.0
carbon source Glycerol (C) +0.2 -1.9 -0.1 N.D. +0.0
stress 7H9 with Clarithromycin 0.967 ug/mL -0.5 -1.1 -0.0 N.D. -0.1
carbon source heptadecanoic 250 uM (C) -0.2 -1.7 -0.1 N.D. +0.3
stress 7H9 with Rifampicin 0.014 ug/mL -0.6 -0.7 -0.3 N.D. +0.1
stress 7H9 with Clofazimine 0.072 ug/mL -0.6 -0.9 -0.1 N.D. +0.0
stress 7H9 with para-aminosalicylic 0.086 ug/mL +0.2 -1.7 +0.0 N.D. -0.0
stress 7H9 with Meropenem 9.6 ug/mL -0.5 -1.4 +0.3 N.D. +0.1
stress 7H9 with Dimethyl Sulfoxide 1 vol% +0.1 -1.8 +0.0 N.D. +0.2
carbon source Valeric 10 mM (C) -0.8 -0.7 -0.1 N.D. +0.2
no stress control no stress control -0.4 -1.0 +0.1 N.D. +0.1
carbon source heptadecanoic 250 uM (C) -0.2 -1.1 -0.1 N.D. +0.3
stress 7H9 with Ethambutol 0.75 ug/mL +0.1 -0.9 -0.4 N.D. +0.1
stress 7H9 with Bedaquiline 0.15 ug/mL -1.3 +0.4 -0.0 N.D. -0.0
stress 7H9 with Clofazimine 0.45 ug/mL -1.2 +0.5 -0.1 N.D. +0.1
nitrogen source L-Valine 10 mM (N) +0.6 -1.5 +0.2 N.D. +0.1
stress 7H9 with Clofazimine 0.45 ug/mL -0.8 +0.7 -0.3 N.D. -0.1
carbon source L-Aspartic Acid (C) -0.8 +0.6 +0.1 N.D. +0.0
stress 7H9 with Isoniazid 0.025 ug/mL -0.8 +1.1 -0.2 N.D. +0.0
carbon source casaminos 1 mg/mL (C) -0.6 +0.8 -0.0 N.D. -0.0
stress 7H9 with Levofloxacin 0.3 ug/mL -0.8 +0.8 +0.1 N.D. +0.1
carbon source D-Glucose (C) -0.7 +1.4 +0.1 N.D. +0.0
carbon source pyruvate (C) -0.5 +1.1 +0.2 N.D. +0.1
carbon source pyruvate (C) -0.3 +1.0 +0.3 N.D. +0.1
carbon source L-Asparagine (C) -0.2 +1.3 -0.0 N.D. +0.0
stress 7H9 with Ethionamide 0.1 ug/mL +0.5 +1.0 +0.0 N.D. +0.2
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