Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3003c and Rv3004 are separated by 361 nucleotidesRv3004 and Rv3005c are separated by 6 nucleotidesRv3005c and Rv3006 are separated by 176 nucleotidesRv3006 and Rv3007c are separated by 5 nucleotides Rv3003c: Rv3003c - Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase), at 3,361,130 to 3,362,986 Rv3003c Rv3004: Rv3004 - Low molecular weight protein antigen 6 (CFP-6), at 3,363,348 to 3,363,686 Rv3004 Rv3005c: Rv3005c - Conserved hypothetical protein, at 3,363,693 to 3,364,532 Rv3005c Rv3006: Rv3006 - Probable conserved lipoprotein LppZ, at 3,364,709 to 3,365,830 Rv3006 Rv3007c: Rv3007c - Possible oxidoreductase, at 3,365,836 to 3,366,450 Rv3007c
Group Condition Rv3003c Rv3004 Rv3005c Rv3006 Rv3007c
stress 7H9 with Rifampicin 0.00045 ug/mL N.D. -0.3 -3.1 N.D. -0.1
stress 7H9 with Rifampicin 0.00045 ug/mL N.D. +0.2 -3.4 N.D. +0.1
stress 7H9 with Rifampicin 0.014 ug/mL N.D. -0.0 -2.7 N.D. +0.5
stress 7H9 with Rifampicin 0.014 ug/mL N.D. -0.0 -2.6 N.D. +0.5
stress 7H9 with Clofazimine 0.45 ug/mL N.D. -0.2 -1.6 N.D. -0.2
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. -0.4 -1.1 N.D. -0.4
nitrogen source L-Alanine 10 mM (N) N.D. -0.5 -1.1 N.D. -0.2
carbon source L-Lactate 10 mM (C) N.D. -0.4 -1.0 N.D. -0.3
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. -0.0 -1.6 N.D. -0.0
nitrogen source L-Valine 10 mM (N) N.D. -0.6 -0.7 N.D. -0.3
nitrogen source L-Aspartic Acid 10 mM (N) N.D. -0.7 -1.3 N.D. +0.3
stress 7H9 with para-aminosalicylic 0.086 ug/mL N.D. -0.2 -0.7 N.D. -0.6
stress 7H9 with Meropenem 9.6 ug/mL N.D. -0.2 -0.7 N.D. -0.6
stress 7H9 with Clofazimine 0.072 ug/mL N.D. -0.2 -1.4 N.D. +0.2
carbon source D-Trehalose 10 mM (C) N.D. -0.8 -0.5 N.D. +0.1
nitrogen source L-Asparagine 10 mM (N) N.D. +0.2 -1.3 N.D. -0.2
stress 7H9 with Hygromycin B 0.0095 mM N.D. +0.2 -0.7 N.D. -0.7
stress 7H9 with Clofazimine 0.072 ug/mL N.D. +0.1 -1.5 N.D. +0.2
nitrogen source L-Glutamic 10 mM (N) N.D. -0.3 -0.9 N.D. +0.2
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. +0.7 -1.8 N.D. +0.2
stress 7H9 with Clofazimine 0.45 ug/mL N.D. +0.0 -1.3 N.D. +0.4
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. +0.4 -1.1 N.D. -0.1
nitrogen source L-Serine 10 mM (N) N.D. +0.3 -0.5 N.D. -0.6
nitrogen source L-Glutamic 10 mM (N) N.D. -0.4 -0.6 N.D. +0.5
carbon source Glycerol (C) N.D. -0.3 -0.8 N.D. +0.6
stress 7H9 with Clarithromycin 0.967 ug/mL N.D. +0.6 -1.1 N.D. +0.1
stress 7H9 with Clarithromycin 0.967 ug/mL N.D. +0.4 -1.1 N.D. +0.5
carbon source Stearic 100 uM (C) N.D. +0.7 -0.8 N.D. +0.1
nitrogen source L-Glutamine 10 mM (N) N.D. +1.1 -0.7 N.D. -0.2
stress 7H9 with Ethionamide 0.1 ug/mL N.D. +0.8 -0.4 N.D. +0.3
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