Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv3001c and Rv3002c are separated by 37 nucleotidesRv3002c and Rv3003c overlap by 1 nucleotidesRv3003c and Rv3004 are separated by 361 nucleotidesRv3004 and Rv3005c are separated by 6 nucleotides Rv3001c: Rv3001c - Probable KETOL-acid reductoisomerase IlvC (acetohydroxy-acid isomeroreductase) (alpha-keto-beta-hydroxylacil reductoisomerase), at 3,359,585 to 3,360,586 Rv3001c Rv3002c: Rv3002c - Probable acetolactate synthase (small subunit) IlvN (acetohydroxy-acid synthase) (AHAS) (ALS), at 3,360,624 to 3,361,130 Rv3002c Rv3003c: Rv3003c - Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase), at 3,361,130 to 3,362,986 Rv3003c Rv3004: Rv3004 - Low molecular weight protein antigen 6 (CFP-6), at 3,363,348 to 3,363,686 Rv3004 Rv3005c: Rv3005c - Conserved hypothetical protein, at 3,363,693 to 3,364,532 Rv3005c
Group Condition Rv3001c Rv3002c Rv3003c Rv3004 Rv3005c
stress 7H9 with Rifampicin 0.00045 ug/mL N.D. N.D. N.D. -0.3 -3.2
stress 7H9 with Rifampicin 0.00045 ug/mL N.D. N.D. N.D. +0.2 -3.4
stress 7H9 with Rifampicin 0.014 ug/mL N.D. N.D. N.D. -0.0 -2.7
stress 7H9 with Rifampicin 0.014 ug/mL N.D. N.D. N.D. -0.0 -2.6
stress 7H9 with Levofloxacin 0.3 ug/mL N.D. N.D. N.D. -1.4 -0.7
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM N.D. N.D. N.D. -1.5 -0.5
nitrogen source L-Aspartic Acid 10 mM (N) N.D. N.D. N.D. -0.7 -1.3
stress 7H9 with Novobiocin 0.004 mM N.D. N.D. N.D. -0.7 -1.2
stress 7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM N.D. N.D. N.D. -1.0 -0.9
stress 7H9 with Clofazimine 0.45 ug/mL N.D. N.D. N.D. -0.2 -1.6
stress 7H9 with Tetracycline 0.0058 mM N.D. N.D. N.D. -0.7 -1.1
stress 7H9 with Erythromycin 0.016 mM N.D. N.D. N.D. -0.3 -1.3
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. N.D. N.D. -0.0 -1.6
stress 7H9 with Clofazimine 0.072 ug/mL N.D. N.D. N.D. -0.2 -1.5
stress 7H9 with Phenazine ethosulfate 0.0137 mM N.D. N.D. N.D. -0.4 -1.2
nitrogen source L-Alanine 10 mM (N) N.D. N.D. N.D. -0.5 -1.2
pH pH 4.5 N.D. N.D. N.D. +0.2 -1.7
pH pH 4.5 N.D. N.D. N.D. +0.4 -1.6
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. N.D. N.D. +0.7 -1.8
stress 7H9 with Clarithromycin 0.967 ug/mL N.D. N.D. N.D. +0.6 -1.1
stress 7H9 with Phenazine ethosulfate 0.0137 mM N.D. N.D. N.D. +0.6 -1.1
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM N.D. N.D. N.D. +0.7 -1.2
stress 7H9 with Lomefloxacin 0.0035 mM N.D. N.D. N.D. +1.0 -1.0
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 N.D. N.D. N.D. +1.4 -1.1
nitrogen source L-Glutamine 10 mM (N) N.D. N.D. N.D. +1.1 -0.6
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 N.D. N.D. N.D. -0.3 +1.4
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 N.D. N.D. N.D. -0.3 +1.5
stress 7H9 with nitrite 1.5 mM; pH 5.5 N.D. N.D. N.D. +0.2 +1.5
pH pH 5.5 N.D. N.D. N.D. +0.8 +1.0
stress 7H9 with nitrite 1.5 mM; pH 5.5 N.D. N.D. N.D. +0.8 +1.3
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