Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntGFF3112 and GFF3113 are separated by 39 nucleotidesGFF3113 and Rv2992c are separated by 74 nucleotidesRv2992c and Rv2993c overlap by 4 nucleotidesRv2993c and Rv2994 are separated by 275 nucleotides GFF3112 - tRNA-Glu, at 3,348,547 to 3,348,619 GFF3112 GFF3113 - tRNA-Gln, at 3,348,659 to 3,348,730 GFF3113 Rv2992c: Rv2992c - Glutamyl-tRNA synthetase GltS (glutamate--tRNA ligase) (glutamyl-tRNA synthase) (GLURS), at 3,348,805 to 3,350,277 Rv2992c Rv2993c: Rv2993c - Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase), at 3,350,274 to 3,350,993 Rv2993c Rv2994: Rv2994 - Probable conserved integral membrane protein, at 3,351,269 to 3,352,606 Rv2994
Group Condition GFF3112 GFF3113 Rv2992c Rv2993c Rv2994
carbon source D-Lactate 10 mM (C) N.D. N.D. N.D. -1.0 -0.1
nitrogen source L-Aspartic Acid 10 mM (N) N.D. N.D. N.D. -0.5 -0.3
stress 7H9 with Ethionamide 0.1 ug/mL N.D. N.D. N.D. -0.5 -0.2
nitrogen source L-Alanine 10 mM (N) N.D. N.D. N.D. -0.5 -0.2
carbon source D-Trehalose 10 mM (C) N.D. N.D. N.D. -0.5 -0.2
stress 7H9 with Streptomycin 0.178 ug/mL N.D. N.D. N.D. -0.4 -0.2
stress 7H9 with Pretomanid 0.213 ug/mL N.D. N.D. N.D. -0.6 -0.0
carbon source D,L-Malic Acid 10 mM (C) N.D. N.D. N.D. -0.5 -0.1
nitrogen source L-Glutamine 10 mM (N) N.D. N.D. N.D. -0.6 +0.2
no stress control no stress control N.D. N.D. N.D. +0.3 -0.3
nitrogen source L-Asparagine 10 mM (N) N.D. N.D. N.D. +0.3 -0.3
nitrogen source L-Aspartic Acid 10 mM (N) N.D. N.D. N.D. +0.4 -0.3
stress 7H9 with para-aminosalicylic 0.086 ug/mL N.D. N.D. N.D. +0.5 -0.4
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. N.D. N.D. +0.3 -0.2
carbon source Stearic 100 uM (C) N.D. N.D. N.D. -0.2 +0.3
nitrogen source L-Glutamic 10 mM (N) N.D. N.D. N.D. +0.5 -0.2
stress 7H9 with Sulfamethizole 0.026 mM N.D. N.D. N.D. +0.6 -0.2
nitrogen source Glycine 10 mM (N) N.D. N.D. N.D. +0.5 -0.1
carbon source propionate (C) N.D. N.D. N.D. +0.5 +0.1
stress 7H9 with Sulfaquinoxaline 0.097 mM N.D. N.D. N.D. +0.5 +0.1
carbon source Valeric 10 mM (C) N.D. N.D. N.D. +0.4 +0.3
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. N.D. N.D. +0.6 +0.1
stress 7H9 with Pretomanid 0.213 ug/mL N.D. N.D. N.D. +0.7 +0.1
nitrogen source L-Glutamine 10 mM (N) N.D. N.D. N.D. +0.8 +0.0
carbon source L-Glutamine (C) N.D. N.D. N.D. +0.8 +0.1
stress 7H9 with Clarithromycin 0.967 ug/mL N.D. N.D. N.D. +1.1 -0.2
stress 7H9 with Meropenem 9.6 ug/mL N.D. N.D. N.D. +0.6 +0.3
stress 7H9 with Sulfamethizole 0.026 mM N.D. N.D. N.D. +1.1 -0.2
carbon source Palmitic 100 uM (C) N.D. N.D. N.D. +0.8 +0.1
carbon source Glycerol (C) N.D. N.D. N.D. +1.0 +0.1
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