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Fitness for 5 genes in
Mycobacterium tuberculosis H37Rv
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Top 30 experiments (either direction), sorted by average fitness
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500 nt
Rv2937 and Rv2938 overlap by 4 nucleotides
Rv2938 and Rv2939 are separated by 46 nucleotides
Rv2939 and Rv2940c are separated by 162 nucleotides
Rv2940c and Rv2941 are separated by 619 nucleotides
Rv2937: Rv2937 - Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB, at 3,273,206 to 3,274,075
Rv2937
Rv2938: Rv2938 - Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC, at 3,274,072 to 3,274,902
Rv2938
Rv2939: Rv2939 - Possible conserved polyketide synthase associated protein PapA5, at 3,274,949 to 3,276,217
Rv2939
Rv2940c: Rv2940c - Probable multifunctional mycocerosic acid synthase membrane-associated Mas, at 3,276,380 to 3,282,715
Rv2940c
Rv2941: Rv2941 - Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase), at 3,283,335 to 3,285,077
Rv2941
Group
Condition
Rv2937
Rv2938
Rv2939
Rv2940c
Rv2941
stress
7H9 with Rifampicin 0.00045 ug/mL
-1.2
-1.4
+0.8
+0.7
+0.7
stress
7H9 with Rifampicin 0.00045 ug/mL
-0.9
-1.1
+1.1
+1.1
+1.0
stress
7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM
-0.8
-0.9
+1.7
+1.8
+1.6
stress
7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM
-0.6
-0.5
+1.6
+1.6
+1.6
pH
pH 4.5
-0.3
-0.2
+1.5
+1.5
+1.4
carbon source
L-Glutamine (C)
-0.5
-0.5
+1.7
+1.8
+1.7
nitrogen source
Glycine 10 mM (N)
-0.3
-0.2
+1.5
+1.7
+1.6
carbon source
L-Glutamine (C)
-0.3
-0.4
+1.6
+1.8
+1.7
stress
7H9 with hypochlorite 0.4 vol%
+0.3
+0.2
+1.4
+1.4
+1.4
carbon source
L-Lactate 10 mM (C)
+0.2
+0.1
+1.5
+1.5
+1.4
no stress control
no stress control
+0.2
+0.2
+1.5
+1.5
+1.4
carbon source
L-Lactate 10 mM (C)
+0.2
+0.1
+1.5
+1.5
+1.5
no stress control
no stress control
+0.4
+0.4
+1.4
+1.4
+1.4
stress
7H9 with Dicloxacillin 0.0069 mM
+0.0
+0.1
+1.7
+1.7
+1.6
stress
7H9 with Dimethyl Sulfoxide 1 vol%
-0.2
-0.1
+1.9
+1.8
+1.8
stress
7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM
-0.2
-0.0
+1.9
+2.0
+1.8
nitrogen source
L-Asparagine 10 mM (N)
-0.4
-0.3
+2.0
+2.1
+2.2
no stress control
no stress control
+0.2
+0.2
+1.7
+1.9
+1.7
no stress control
no stress control
+0.3
+0.4
+1.8
+1.7
+1.8
stress
7H9 with Amikacin di2 ug/mL
+0.4
+0.5
+1.8
+1.7
+1.7
stress
7H9 with Dimethyl Sulfoxide 1 vol%
+0.2
-0.1
+2.2
+2.0
+2.0
stress
7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM
+0.1
+0.1
+2.1
+2.2
+2.0
carbon source
oleate 200uM (C)
-0.4
-0.1
+2.4
+2.5
+2.4
no stress control
no stress control
+0.8
+0.7
+1.9
+1.9
+1.8
nitrogen source
L-Asparagine 10 mM (N)
-0.1
-0.1
+2.4
+2.4
+2.5
carbon source
oleate 200uM (C)
-0.3
-0.2
+2.8
+2.9
+2.9
nitrogen source
L-Glutamine 10 mM (N)
-0.3
-0.3
+3.6
+3.7
+3.7
nitrogen source
L-Glutamine 10 mM (N)
-0.5
-0.3
+3.8
+3.8
+3.8
nitrogen source
L-Glutamic 10 mM (N)
-0.2
+0.0
+4.5
+4.7
+4.7
nitrogen source
L-Glutamic 10 mM (N)
-0.1
-0.1
+4.6
+4.7
+4.7
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