Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2937 and Rv2938 overlap by 4 nucleotidesRv2938 and Rv2939 are separated by 46 nucleotidesRv2939 and Rv2940c are separated by 162 nucleotidesRv2940c and Rv2941 are separated by 619 nucleotides Rv2937: Rv2937 - Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB, at 3,273,206 to 3,274,075 Rv2937 Rv2938: Rv2938 - Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC, at 3,274,072 to 3,274,902 Rv2938 Rv2939: Rv2939 - Possible conserved polyketide synthase associated protein PapA5, at 3,274,949 to 3,276,217 Rv2939 Rv2940c: Rv2940c - Probable multifunctional mycocerosic acid synthase membrane-associated Mas, at 3,276,380 to 3,282,715 Rv2940c Rv2941: Rv2941 - Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase), at 3,283,335 to 3,285,077 Rv2941
Group Condition Rv2937 Rv2938 Rv2939 Rv2940c Rv2941
stress 7H9 with Rifampicin 0.00045 ug/mL -1.2 -1.4 +0.8 +0.7 +0.7
stress 7H9 with Rifampicin 0.00045 ug/mL -0.9 -1.1 +1.1 +1.1 +1.0
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM -0.8 -0.9 +1.7 +1.8 +1.6
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM -0.6 -0.5 +1.6 +1.6 +1.6
pH pH 4.5 -0.3 -0.2 +1.5 +1.5 +1.4
carbon source L-Glutamine (C) -0.5 -0.5 +1.7 +1.8 +1.7
nitrogen source Glycine 10 mM (N) -0.3 -0.2 +1.5 +1.7 +1.6
carbon source L-Glutamine (C) -0.3 -0.4 +1.6 +1.8 +1.7
stress 7H9 with hypochlorite 0.4 vol% +0.3 +0.2 +1.4 +1.4 +1.4
carbon source L-Lactate 10 mM (C) +0.2 +0.1 +1.5 +1.5 +1.4
no stress control no stress control +0.2 +0.2 +1.5 +1.5 +1.4
carbon source L-Lactate 10 mM (C) +0.2 +0.1 +1.5 +1.5 +1.5
no stress control no stress control +0.4 +0.4 +1.4 +1.4 +1.4
stress 7H9 with Dicloxacillin 0.0069 mM +0.0 +0.1 +1.7 +1.7 +1.6
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.2 -0.1 +1.9 +1.8 +1.8
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM -0.2 -0.0 +1.9 +2.0 +1.8
nitrogen source L-Asparagine 10 mM (N) -0.4 -0.3 +2.0 +2.1 +2.2
no stress control no stress control +0.2 +0.2 +1.7 +1.9 +1.7
no stress control no stress control +0.3 +0.4 +1.8 +1.7 +1.8
stress 7H9 with Amikacin di2 ug/mL +0.4 +0.5 +1.8 +1.7 +1.7
stress 7H9 with Dimethyl Sulfoxide 1 vol% +0.2 -0.1 +2.2 +2.0 +2.0
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM +0.1 +0.1 +2.1 +2.2 +2.0
carbon source oleate 200uM (C) -0.4 -0.1 +2.4 +2.5 +2.4
no stress control no stress control +0.8 +0.7 +1.9 +1.9 +1.8
nitrogen source L-Asparagine 10 mM (N) -0.1 -0.1 +2.4 +2.4 +2.5
carbon source oleate 200uM (C) -0.3 -0.2 +2.8 +2.9 +2.9
nitrogen source L-Glutamine 10 mM (N) -0.3 -0.3 +3.6 +3.7 +3.7
nitrogen source L-Glutamine 10 mM (N) -0.5 -0.3 +3.8 +3.8 +3.8
nitrogen source L-Glutamic 10 mM (N) -0.2 +0.0 +4.5 +4.7 +4.7
nitrogen source L-Glutamic 10 mM (N) -0.1 -0.1 +4.6 +4.7 +4.7
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