Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2921c and Rv2922c are separated by 49 nucleotidesRv2922c and Rv2922A are separated by 11 nucleotidesRv2922A and Rv2923c overlap by 14 nucleotidesRv2923c and Rv2924c are separated by 101 nucleotides Rv2921c: Rv2921c - Probable cell division protein FtsY (SRP receptor) (signal recognition particle receptor), at 3,232,871 to 3,234,139 Rv2921c Rv2922c: Rv2922c - Probable chromosome partition protein Smc, at 3,234,189 to 3,237,806 Rv2922c Rv2922A: Rv2922A - Probable acylphosphatase AcyP (acylphosphate phosphohydrolase), at 3,237,818 to 3,238,099 Rv2922A Rv2923c: Rv2923c - Conserved protein, at 3,238,086 to 3,238,499 Rv2923c Rv2924c: Rv2924c - Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase), at 3,238,601 to 3,239,470 Rv2924c
Group Condition Rv2921c Rv2922c Rv2922A Rv2923c Rv2924c
nitrogen source L-Serine 10 mM (N) N.D. -0.8 N.D. -0.9 -0.1
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. -0.9 N.D. -1.2 +0.3
nitrogen source L-Asparagine 10 mM (N) N.D. -0.8 N.D. -0.5 -0.1
nitrogen source L-Glutamic 10 mM (N) N.D. -0.7 N.D. -0.6 -0.1
stress 7H9 with Pretomanid 0.213 ug/mL N.D. -0.3 N.D. -1.0 -0.2
nitrogen source L-Aspartic Acid 10 mM (N) N.D. -0.1 N.D. -1.4 +0.1
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. -0.6 N.D. -0.5 -0.2
nitrogen source L-Glutamine 10 mM (N) N.D. -0.5 N.D. -0.7 -0.0
nitrogen source L-Glutamic 10 mM (N) N.D. -0.6 N.D. -0.3 -0.4
no stress control no stress control N.D. -1.0 N.D. -0.5 +0.2
stress 7H9 with Rifampicin 0.014 ug/mL N.D. -0.2 N.D. -0.7 -0.2
no stress control no stress control N.D. -0.8 N.D. -0.2 -0.0
no stress control no stress control N.D. -0.3 N.D. -0.7 -0.0
carbon source D-Glucose (C) N.D. -0.2 N.D. -0.8 +0.1
stress 7H9 with Hygromycin B 0.0095 mM N.D. -0.5 N.D. -0.6 +0.1
carbon source L-Lactate 10 mM (C) N.D. -0.5 N.D. -0.6 +0.2
stress 7H9 with Clofazimine 0.072 ug/mL N.D. +0.2 N.D. -1.0 +0.1
stress 7H9 with Isoniazid 0.025 ug/mL N.D. -0.8 N.D. +0.2 +0.1
stress 7H9 with Meropenem 9.6 ug/mL N.D. -0.8 N.D. +0.2 +0.1
carbon source D-Lactate 10 mM (C) N.D. -0.7 N.D. +0.2 +0.1
stress 7H9 with Isoniazid 0.025 ug/mL N.D. -1.2 N.D. +0.7 +0.1
carbon source Stearic 100 uM (C) N.D. -0.8 N.D. +0.5 +0.0
no stress control no stress control N.D. -0.8 N.D. +0.8 -0.2
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. -0.9 N.D. +0.5 +0.2
carbon source propionate (C) N.D. -0.4 N.D. +0.6 -0.2
stress 7H9 with Levofloxacin 0.3 ug/mL N.D. -0.7 N.D. +0.5 +0.2
stress 7H9 with Ethionamide 0.1 ug/mL N.D. -0.4 N.D. +0.6 -0.1
stress 7H9 with Dimethyl Sulfoxide 1 vol% N.D. -0.4 N.D. +0.7 -0.2
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. -0.3 N.D. +0.6 +0.1
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. -0.2 N.D. +1.1 +0.2
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