Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2878c and Rv2879c are separated by 185 nucleotidesRv2879c and Rv2880c overlap by 302 nucleotidesRv2880c and Rv2881c are separated by 22 nucleotidesRv2881c and Rv2882c are separated by 22 nucleotides Rv2878c: Rv2878c - Soluble secreted antigen Mpt53 precursor, at 3,188,876 to 3,189,397 Rv2878c Rv2879c: Rv2879c - Conserved hypothetical protein, at 3,189,583 to 3,190,152 Rv2879c Rv2880c: Rv2880c - Conserved hypothetical protein, at 3,189,851 to 3,190,678 Rv2880c Rv2881c: Rv2881c - Probable integral membrane phosphatidate cytidylyltransferase CdsA (CDP-diglyceride synthetase) (CDP-diglyceride pyrophosphorylase) (CDP-diacylglycerol synthase) (CDS) (CTP:phosphatidate cytidylyltransferase) (CDP-DAG synthase) (CDP-DG synthetase), at 3,190,701 to 3,191,621 Rv2881c Rv2882c: Rv2882c - Ribosome recycling factor Frr (ribosome releasing factor) (RRF), at 3,191,644 to 3,192,201 Rv2882c
Group Condition Rv2878c Rv2879c Rv2880c Rv2881c Rv2882c
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -0.2 -1.7 -0.2 N.D. N.D.
pH pH 5.5 -0.1 -1.7 -0.2 N.D. N.D.
stress 7H9 with nitrite 1.5 mM; pH 5.5 -0.2 -1.7 -0.0 N.D. N.D.
nitrogen source L-Alanine 10 mM (N) -0.1 -1.8 -0.0 N.D. N.D.
nitrogen source L-Glutamic 10 mM (N) -0.2 -2.0 +0.4 N.D. N.D.
no stress control no stress control +0.1 -1.9 +0.0 N.D. N.D.
stress 7H9 with Antimycin A 0.0186 mM -0.0 -1.6 -0.1 N.D. N.D.
stress 7H9 with Cloxacillin 0.0386 mM +0.1 -1.2 -0.4 N.D. N.D.
stress 7H9 with 8-hydroxy-nitroquinoline 0.03 mM +0.0 -1.5 -0.0 N.D. N.D.
stress 7H9 with Cloxacillin 0.0386 mM +0.1 -1.4 -0.1 N.D. N.D.
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM +0.1 -1.3 -0.2 N.D. N.D.
stress 7H9 with Thioridazine 0.028 mM +0.3 -1.4 -0.2 N.D. N.D.
carbon source Stearic 100 uM (C) +0.3 -1.4 -0.1 N.D. N.D.
stress 7H9 with nitrate 4 mM +0.4 -1.3 +0.0 N.D. N.D.
stress 7H9 with Tetrazolium violet 0.065 mM +0.3 -1.3 +0.3 N.D. N.D.
nitrogen source L-Glutamic 10 mM (N) -0.0 -1.2 +0.7 N.D. N.D.
stress 7H9 with copper (II) chloride 0.08 mM +0.6 -0.6 +0.3 N.D. N.D.
no stress control no stress control -0.0 +1.3 -0.2 N.D. N.D.
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 +0.5 +0.9 -0.2 N.D. N.D.
carbon source oleate 200uM (C) -0.2 +1.3 +0.0 N.D. N.D.
stress 7H9 with Linezolid 0.3 ug/mL +0.1 +1.4 -0.3 N.D. N.D.
stress 7H9 with Dodecyl Sulfate 0.02 vol% +0.2 +1.1 +0.2 N.D. N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL +0.2 +1.3 +0.0 N.D. N.D.
stress 7H9 with Zinc Pyrithione 0.00072 mM +0.1 +1.1 +0.4 N.D. N.D.
carbon source oleate 200uM (C) +0.2 +1.6 -0.1 N.D. N.D.
stress 7H9 with Levofloxacin 0.3 ug/mL -0.0 +2.1 -0.0 N.D. N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.0 +2.1 -0.1 N.D. N.D.
stress 7H9 with Ofloxacin 0.8 ug/mL +0.1 +1.8 +0.1 N.D. N.D.
stress 7H9 with Isoniazid 0.025 ug/mL +0.2 +1.9 +0.4 N.D. N.D.
stress 7H9 with Ethionamide 0.1 ug/mL +0.1 +2.5 +0.2 N.D. N.D.
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