Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2851c and Rv2852c are separated by 58 nucleotidesRv2852c and Rv2853 are separated by 206 nucleotidesRv2853 and Rv2854 are separated by 36 nucleotidesRv2854 and Rv2855 are separated by 12 nucleotides Rv2851c: Rv2851c - GCN5-related N-acetyltransferase, at 3,160,051 to 3,160,521 Rv2851c Rv2852c: Rv2852c - Probable malate:quinone oxidoreductase Mqo (malate dehydrogenase [acceptor]), at 3,160,580 to 3,162,061 Rv2852c Rv2853: Rv2853 - PE-PGRS family protein PE_PGRS48, at 3,162,268 to 3,164,115 Rv2853 Rv2854: Rv2854 - Unknown protein, at 3,164,152 to 3,165,192 Rv2854 Rv2855: Rv2855 - NADPH-dependent mycothiol reductase Mtr, at 3,165,205 to 3,166,584 Rv2855
Group Condition Rv2851c Rv2852c Rv2853 Rv2854 Rv2855
carbon source butyrate 10 mM (C) -1.6 -0.3 -0.2 -0.1 -0.1
stress 7H9 with Meropenem 9.6 ug/mL -1.0 -0.0 -0.2 -0.3 -0.8
carbon source heptadecanoic 250 uM (C) -0.5 -0.2 -0.2 -0.4 -0.7
carbon source butyrate 10 mM (C) -1.3 -0.4 -0.2 +0.2 -0.2
stress 7H9 with Rifampicin 0.014 ug/mL -0.7 -0.2 -0.1 -0.1 -0.7
carbon source Stearic 100 uM (C) -0.5 -0.4 -0.2 -0.4 -0.2
stress 7H9 with Linezolid 0.44 ug/mL -0.4 -0.1 -0.1 +0.1 -1.0
carbon source Stearic 100 uM (C) -0.7 -0.3 +0.1 -0.0 -0.4
carbon source L-Lactate 10 mM (C) -0.4 -0.4 -0.0 -0.2 -0.4
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.2 -0.2 -0.3 -0.0 -0.6
nitrogen source L-Asparagine 10 mM (N) -0.7 -0.2 -0.0 -0.1 -0.3
stress 7H9 with Rifampicin 0.00045 ug/mL -0.6 -0.1 -0.0 -0.0 -0.4
carbon source D-Trehalose 10 mM (C) -0.6 -0.2 -0.1 -0.0 -0.2
stress 7H9 with Rifampicin 0.00045 ug/mL -0.3 -0.1 +0.1 +0.0 -0.8
stress 7H9 with Bedaquiline 0.15 ug/mL -0.4 -0.1 -0.2 +0.1 -0.6
stress 7H9 with Clofazimine 0.072 ug/mL -0.5 -0.1 +0.1 +0.1 -0.5
nitrogen source L-Glutamic 10 mM (N) -0.3 -0.1 +0.0 +0.2 -0.8
stress 7H9 with Hygromycin B 0.0095 mM -0.0 -0.1 -0.2 +0.1 -0.7
no stress control no stress control -0.3 -0.2 +0.1 +0.1 -0.5
carbon source L-Glutamine (C) -0.6 -0.0 -0.0 -0.4 +0.4
stress 7H9 with Rifampicin 0.014 ug/mL -0.6 -0.2 +0.0 +0.4 -0.1
stress 7H9 with Bedaquiline 0.15 ug/mL -0.1 -0.3 +0.1 +0.2 -0.4
carbon source D-Lactate 10 mM (C) -0.3 +0.1 -0.1 +0.3 -0.5
stress 7H9 with Sulfamethizole 0.026 mM +0.6 -0.1 -0.1 -0.3 -0.3
no stress control no stress control +0.5 -0.0 +0.1 -0.5 -0.1
stress 7H9 with Isoniazid 0.025 ug/mL +0.2 +0.0 -0.3 +0.2 +0.5
nitrogen source L-Glutamine 10 mM (N) -0.2 -0.1 -0.1 +0.1 +1.0
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.2 -0.2 +0.1 +0.5 +0.2
stress 7H9 with Ofloxacin 0.8 ug/mL +0.2 -0.2 -0.1 +0.3 +0.7
stress 7H9 with Isoniazid 0.025 ug/mL +0.0 -0.2 -0.1 +0.5 +0.8
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