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Fitness for 5 genes in
Mycobacterium tuberculosis H37Rv
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Top 30 experiments (either direction), sorted by average fitness
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500 nt
Rv2851c and Rv2852c are separated by 58 nucleotides
Rv2852c and Rv2853 are separated by 206 nucleotides
Rv2853 and Rv2854 are separated by 36 nucleotides
Rv2854 and Rv2855 are separated by 12 nucleotides
Rv2851c: Rv2851c - GCN5-related N-acetyltransferase, at 3,160,051 to 3,160,521
Rv2851c
Rv2852c: Rv2852c - Probable malate:quinone oxidoreductase Mqo (malate dehydrogenase [acceptor]), at 3,160,580 to 3,162,061
Rv2852c
Rv2853: Rv2853 - PE-PGRS family protein PE_PGRS48, at 3,162,268 to 3,164,115
Rv2853
Rv2854: Rv2854 - Unknown protein, at 3,164,152 to 3,165,192
Rv2854
Rv2855: Rv2855 - NADPH-dependent mycothiol reductase Mtr, at 3,165,205 to 3,166,584
Rv2855
Group
Condition
Rv2851c
Rv2852c
Rv2853
Rv2854
Rv2855
carbon source
butyrate 10 mM (C)
-1.6
-0.3
-0.2
-0.1
-0.1
stress
7H9 with Meropenem 9.6 ug/mL
-1.0
-0.0
-0.2
-0.3
-0.8
carbon source
heptadecanoic 250 uM (C)
-0.5
-0.2
-0.2
-0.4
-0.7
carbon source
butyrate 10 mM (C)
-1.3
-0.4
-0.2
+0.2
-0.2
stress
7H9 with Rifampicin 0.014 ug/mL
-0.7
-0.2
-0.1
-0.1
-0.7
carbon source
Stearic 100 uM (C)
-0.5
-0.4
-0.2
-0.4
-0.2
stress
7H9 with Linezolid 0.44 ug/mL
-0.4
-0.1
-0.1
+0.1
-1.0
carbon source
Stearic 100 uM (C)
-0.7
-0.3
+0.1
-0.0
-0.4
carbon source
L-Lactate 10 mM (C)
-0.4
-0.4
-0.0
-0.2
-0.4
stress
7H9 with Dimethyl Sulfoxide 1 vol%
-0.2
-0.2
-0.3
-0.0
-0.6
nitrogen source
L-Asparagine 10 mM (N)
-0.7
-0.2
-0.0
-0.1
-0.3
stress
7H9 with Rifampicin 0.00045 ug/mL
-0.6
-0.1
-0.0
-0.0
-0.4
carbon source
D-Trehalose 10 mM (C)
-0.6
-0.2
-0.1
-0.0
-0.2
stress
7H9 with Rifampicin 0.00045 ug/mL
-0.3
-0.1
+0.1
+0.0
-0.8
stress
7H9 with Bedaquiline 0.15 ug/mL
-0.4
-0.1
-0.2
+0.1
-0.6
stress
7H9 with Clofazimine 0.072 ug/mL
-0.5
-0.1
+0.1
+0.1
-0.5
nitrogen source
L-Glutamic 10 mM (N)
-0.3
-0.1
+0.0
+0.2
-0.8
stress
7H9 with Hygromycin B 0.0095 mM
-0.0
-0.1
-0.2
+0.1
-0.7
no stress control
no stress control
-0.3
-0.2
+0.1
+0.1
-0.5
carbon source
L-Glutamine (C)
-0.6
-0.0
-0.0
-0.4
+0.4
stress
7H9 with Rifampicin 0.014 ug/mL
-0.6
-0.2
+0.0
+0.4
-0.1
stress
7H9 with Bedaquiline 0.15 ug/mL
-0.1
-0.3
+0.1
+0.2
-0.4
carbon source
D-Lactate 10 mM (C)
-0.3
+0.1
-0.1
+0.3
-0.5
stress
7H9 with Sulfamethizole 0.026 mM
+0.6
-0.1
-0.1
-0.3
-0.3
no stress control
no stress control
+0.5
-0.0
+0.1
-0.5
-0.1
stress
7H9 with Isoniazid 0.025 ug/mL
+0.2
+0.0
-0.3
+0.2
+0.5
nitrogen source
L-Glutamine 10 mM (N)
-0.2
-0.1
-0.1
+0.1
+1.0
stress
7H9 with Moxifloxacin 0.121 ug/mL
+0.2
-0.2
+0.1
+0.5
+0.2
stress
7H9 with Ofloxacin 0.8 ug/mL
+0.2
-0.2
-0.1
+0.3
+0.7
stress
7H9 with Isoniazid 0.025 ug/mL
+0.0
-0.2
-0.1
+0.5
+0.8
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