Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2849c and Rv2850c are separated by 20 nucleotidesRv2850c and Rv2851c overlap by 4 nucleotidesRv2851c and Rv2852c are separated by 58 nucleotidesRv2852c and Rv2853 are separated by 206 nucleotides Rv2849c: Rv2849c - Probable cob(I)alamin adenosyltransferase CobO (corrinoid adenosyltransferase) (corrinoid adotransferase activity), at 3,157,521 to 3,158,144 Rv2849c Rv2850c: Rv2850c - Possible magnesium chelatase, at 3,158,165 to 3,160,054 Rv2850c Rv2851c: Rv2851c - GCN5-related N-acetyltransferase, at 3,160,051 to 3,160,521 Rv2851c Rv2852c: Rv2852c - Probable malate:quinone oxidoreductase Mqo (malate dehydrogenase [acceptor]), at 3,160,580 to 3,162,061 Rv2852c Rv2853: Rv2853 - PE-PGRS family protein PE_PGRS48, at 3,162,268 to 3,164,115 Rv2853
Group Condition Rv2849c Rv2850c Rv2851c Rv2852c Rv2853
carbon source butyrate 10 mM (C) -0.2 -1.8 -1.6 -0.3 -0.2
carbon source heptadecanoic 250 uM (C) -0.2 -1.7 -0.1 -0.2 -0.1
carbon source L-Lactate 10 mM (C) -0.2 -0.7 -0.4 -0.4 -0.0
nitrogen source L-Glutamine 10 mM (N) +0.0 -1.2 -0.2 -0.1 -0.1
stress 7H9 with Sulfamethizole 0.026 mM +0.2 -1.0 -0.4 -0.0 -0.0
carbon source butyrate 10 mM (C) -0.1 +0.8 -1.3 -0.4 -0.2
nitrogen source L-Valine 10 mM (N) -0.5 -0.4 -0.1 +0.2 -0.2
carbon source Stearic 100 uM (C) +0.2 -0.1 -0.5 -0.4 -0.2
stress 7H9 with Dimethyl Sulfoxide 1 vol% +0.3 -1.1 -0.0 -0.2 -0.1
stress 7H9 with Meropenem 9.6 ug/mL +0.3 -0.0 -1.0 -0.0 -0.2
carbon source Stearic 100 uM (C) -0.5 +0.5 -0.7 -0.3 +0.1
carbon source D-Glucose (C) +0.4 -0.8 -0.2 -0.1 +0.1
carbon source D-Trehalose 10 mM (C) +0.3 +0.2 -0.6 -0.2 -0.1
stress 7H9 with Bedaquiline 0.15 ug/mL +0.5 -0.2 -0.4 -0.1 -0.2
stress 7H9 with Sulfamethizole 0.026 mM -0.3 -0.2 +0.6 -0.1 -0.1
stress 7H9 with Rifampicin 0.014 ug/mL +0.4 +0.6 -0.7 -0.2 -0.1
stress 7H9 with Clofazimine 0.072 ug/mL +0.2 +0.6 -0.5 -0.1 +0.1
stress 7H9 with Linezolid 0.44 ug/mL +0.1 +0.9 -0.4 -0.1 -0.1
stress 7H9 with Rifampicin 0.014 ug/mL +0.5 +0.7 -0.6 -0.2 +0.0
nitrogen source L-Glutamine 10 mM (N) -0.3 +1.0 -0.3 -0.1 +0.0
nitrogen source L-Glutamic 10 mM (N) -0.2 +1.0 -0.3 -0.1 +0.0
stress 7H9 with Rifampicin 0.00045 ug/mL +0.5 +0.7 -0.6 -0.1 -0.0
carbon source D-Lactate 10 mM (C) +0.0 +0.9 -0.3 +0.1 -0.1
stress 7H9 with Clofazimine 0.072 ug/mL +0.5 +0.7 -0.5 -0.2 -0.0
stress 7H9 with Bedaquiline 0.15 ug/mL +0.4 +0.6 -0.1 -0.3 +0.1
carbon source D-Trehalose 10 mM (C) +0.5 +1.0 -0.5 -0.1 -0.1
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.2 +0.8 +0.2 -0.2 +0.1
carbon source Valeric 10 mM (C) +0.1 +1.2 -0.4 -0.1 +0.1
stress 7H9 with Clofazimine 0.45 ug/mL +0.4 +0.9 -0.3 -0.0 +0.0
stress 7H9 with Isoniazid 0.025 ug/mL -0.2 +1.3 +0.2 +0.0 -0.3
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