Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2670c and Rv2671 overlap by 2 nucleotidesRv2671 and Rv2672 are separated by 66 nucleotidesRv2672 and Rv2673 are separated by 22 nucleotidesRv2673 and Rv2674 are separated by 113 nucleotides Rv2670c: Rv2670c - Conserved hypothetical protein, at 2,985,731 to 2,986,840 Rv2670c Rv2671: Rv2671 - Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase), at 2,986,839 to 2,987,615 Rv2671 Rv2672: Rv2672 - Possible secreted protease, at 2,987,682 to 2,989,268 Rv2672 Rv2673: Rv2673 - Possible arabinofuranosyltransferase AftC, at 2,989,291 to 2,990,592 Rv2673 Rv2674: Rv2674 - Probable peptide methionine sulfoxide reductase MsrB (protein-methionine-R-oxide reductase) (peptide met(O) reductase), at 2,990,706 to 2,991,116 Rv2674
Group Condition Rv2670c Rv2671 Rv2672 Rv2673 Rv2674
stress 7H9 with nitrate 4 mM +0.1 -4.0 +0.5 N.D. -0.4
stress 7H9 with nitrite 2.5 mM -0.1 -3.4 +0.4 N.D. -0.3
pH pH 4.5 -0.1 -0.4 -1.7 N.D. -0.2
stress 7H9 with Hydrogen peroxide 3.97 mM -0.0 -2.1 -0.1 N.D. +0.0
pH pH 4.5 -0.0 -0.5 -1.5 N.D. -0.1
stress 7H9 with Hydrogen peroxide 3.97 mM -0.2 -1.2 -0.4 N.D. -0.0
stress 7H9 with Rifampicin 0.014 ug/mL +0.0 -0.3 -1.4 N.D. -0.0
stress 7H9 with nitrite 5 mM +0.4 -2.5 +0.3 N.D. +0.1
stress 7H9 with Rifampicin 0.014 ug/mL -0.4 -0.3 -1.1 N.D. +0.1
stress 7H9 with Clofazimine 0.45 ug/mL +0.1 -1.2 -0.3 N.D. -0.1
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM -0.6 -1.1 +0.1 N.D. +0.0
stress 7H9 with nitrite 3 mM; pH 5.5 +0.3 -1.8 +0.2 N.D. -0.2
stress 7H9 with Sulfamethizole 0.026 mM -0.0 -1.1 -0.1 N.D. -0.1
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -0.1 -0.8 -0.4 N.D. -0.1
stress 7H9 with nitrite 1.5 mM; pH 5.5 +0.1 -2.2 +0.5 N.D. +0.2
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.1 -0.2 -0.9 N.D. -0.2
stress 7H9 with hypochlorite 0.4 vol% -0.3 -0.4 +0.3 N.D. -0.7
stress 7H9 with Clofazimine 0.072 ug/mL +0.2 -0.8 -0.4 N.D. -0.1
stress 7H9 with nitrite 1.5 mM; pH 5.5 +0.3 -1.5 +0.4 N.D. -0.2
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 +0.4 -1.4 +0.1 N.D. -0.0
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 +0.2 -1.0 +0.0 N.D. -0.1
stress 7H9 with hypochlorite 0.4 vol% -0.0 -0.1 +0.4 N.D. -1.1
stress 7H9 with Rifampicin 0.00045 ug/mL +0.3 -0.3 -0.8 N.D. -0.0
stress 7H9 with Zinc Pyrithione 0.00072 mM -0.8 -0.2 +0.4 N.D. +0.1
stress 7H9 with Phenazine methosulfate 0.0054 mM +0.4 -0.9 +0.0 N.D. +0.1
stress 7H9 with Phenazine methosulfate 0.0054 mM +0.2 -0.9 +0.3 N.D. +0.1
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.5 -0.2 +0.9 N.D. -0.3
carbon source cholesterol 100uM (C) -0.2 +0.6 +0.3 N.D. -0.7
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM +0.0 +1.0 -0.7 N.D. +0.0
carbon source Valeric 10 mM (C) -0.1 +0.3 +0.9 N.D. -0.1
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