Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2620c and Rv2621c overlap by 4 nucleotidesRv2621c and Rv2622 are separated by 77 nucleotidesRv2622 and Rv2623 are separated by 135 nucleotidesRv2623 and Rv2624c are separated by 2 nucleotides Rv2620c: Rv2620c - Probable conserved transmembrane protein, at 2,947,462 to 2,947,887 Rv2620c Rv2621c: Rv2621c - Possible transcriptional regulatory protein, at 2,947,884 to 2,948,558 Rv2621c Rv2622: Rv2622 - Possible methyltransferase (methylase), at 2,948,636 to 2,949,457 Rv2622 Rv2623: Rv2623 - Universal stress protein family protein TB31.7, at 2,949,593 to 2,950,486 Rv2623 Rv2624c: Rv2624c - Universal stress protein family protein, at 2,950,489 to 2,951,307 Rv2624c
Group Condition Rv2620c Rv2621c Rv2622 Rv2623 Rv2624c
stress 7H9 with nitrite 3 mM; pH 5.5 +0.0 -0.5 -0.0 -0.7 -2.0
no stress control no stress control -0.1 -2.6 +0.1 -0.4 +0.1
stress 7H9 with Irgasan 0.065 mM -0.1 +0.1 -0.3 -0.7 -1.8
no stress control no stress control -0.2 -2.0 -0.1 +0.5 -0.4
nitrogen source L-Glutamic 10 mM (N) +0.1 -1.2 +0.1 -0.0 -1.0
nitrogen source Ammonium chloride 10mM (N) -0.1 -0.6 -0.4 +0.2 -1.0
stress 7H9 with Clofazimine 0.072 ug/mL -0.0 -0.6 +0.1 +0.4 -1.6
stress 7H9 with 8-hydroxy-nitroquinoline 0.03 mM -0.1 -1.7 -0.1 +0.1 +0.2
nitrogen source L-Alanine 10 mM (N) +0.0 -0.8 -0.4 +0.3 -0.7
pH pH 4.5 +0.2 -0.1 -0.3 +0.4 -1.6
stress 7H9 with methylglyoxal 1.2 mM -0.1 +0.3 +0.3 -0.5 -1.3
stress 7H9 with Ofloxacin 0.8 ug/mL -0.0 +0.9 +0.0 -0.1 -2.1
stress 7H9 with hypochlorite 0.4 vol% -0.1 -0.3 -0.0 +0.6 -1.4
stress 7H9 with Ceftriaxone hemi(heptahydrate) 0.12 mM +0.2 +0.4 -0.3 -0.5 -0.9
carbon source heptadecanoic 250 uM (C) -0.2 +0.6 +0.0 +0.2 -1.3
pH 7H9 pH 5.5 -0.3 +0.9 -0.2 -0.8 -0.2
stress 7H9 with Levofloxacin 0.3 ug/mL +0.2 +1.2 +0.1 -0.9 -1.0
stress 7H9 with EDTA (disodium salt) 0.2 mM +0.2 -1.3 +0.2 -0.1 +0.6
stress 7H9 with Ofloxacin 0.8 ug/mL +0.0 +0.9 +0.2 -0.4 -1.0
stress 7H9 with Antimycin A 0.0186 mM +0.4 -0.8 -0.5 +0.0 +0.5
stress 7H9 with Ethionamide 0.1 ug/mL +0.2 +1.0 +0.2 -0.3 -1.2
stress 7H9 with Nickel (II) chloride 0.6 mM +0.1 -1.1 -0.0 +0.5 +0.7
stress 7H9 with Lomefloxacin 0.0035 mM -0.1 -0.5 -0.2 -0.2 +1.3
stress 7H9 with nitrite 5 mM +0.2 +0.5 -0.9 -0.0 +0.9
stress 7H9 with Isoniazid 0.025 ug/mL +0.2 +2.6 -0.1 -0.4 -1.0
carbon source D,L-Malic Acid 10 mM (C) +0.0 +1.1 -0.5 +0.2 +0.5
stress 7H9 with Ciprofloxacin Hydrochloride 0.0012 mM -0.1 +1.1 +0.3 +0.6 -0.6
carbon source D-Trehalose 10 mM (C) +0.1 +0.9 -0.2 -0.1 +0.7
no stress control no stress control +0.3 +0.2 +0.4 +0.3 +0.9
stress 7H9 with copper (II) chloride 0.08 mM -0.2 +1.3 +0.2 +0.9 +0.7
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