Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2614c and Rv2614A are separated by 108 nucleotidesRv2614A and Rv2615c overlap by 4 nucleotidesRv2615c and Rv2616 are separated by 344 nucleotidesRv2616 and Rv2617c are separated by 16 nucleotides Rv2614c: Rv2614c - Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase), at 2,941,189 to 2,943,267 Rv2614c Rv2614A: Rv2614A - Conserved hypothetical protein, at 2,943,376 to 2,943,603 Rv2614A Rv2615c: Rv2615c - PE-PGRS family protein PE_PGRS45, at 2,943,600 to 2,944,985 Rv2615c Rv2616: Rv2616 - Conserved protein, at 2,945,330 to 2,945,830 Rv2616 Rv2617c: Rv2617c - Probable transmembrane protein, at 2,945,847 to 2,946,287 Rv2617c
Group Condition Rv2614c Rv2614A Rv2615c Rv2616 Rv2617c
stress 7H9 with Ethionamide 0.1 ug/mL N.D. N.D. -0.7 -0.4 -0.0
stress 7H9 with Hygromycin B 0.0095 mM N.D. N.D. -0.3 -0.9 +0.1
no stress control no stress control N.D. N.D. -0.5 -0.3 -0.0
stress 7H9 with Isoniazid 0.025 ug/mL N.D. N.D. -0.9 +0.0 +0.1
stress 7H9 with Rifampicin 0.014 ug/mL N.D. N.D. -0.4 -0.2 -0.2
nitrogen source Glycine 10 mM (N) N.D. N.D. +0.2 -0.8 -0.1
stress 7H9 with Clofazimine 0.45 ug/mL N.D. N.D. -0.6 -0.1 +0.0
stress 7H9 with Clarithromycin 0.967 ug/mL N.D. N.D. -0.3 -0.4 +0.0
nitrogen source L-Glutamine 10 mM (N) N.D. N.D. +0.1 -0.6 -0.1
stress 7H9 with Rifampicin 0.014 ug/mL N.D. N.D. -0.5 +0.2 -0.1
carbon source D-Glucose (C) N.D. N.D. -0.3 -0.3 +0.1
stress 7H9 with Ofloxacin 0.8 ug/mL N.D. N.D. -0.4 -0.2 +0.1
no stress control no stress control N.D. N.D. -0.1 -0.5 +0.2
stress 7H9 with Streptomycin 0.178 ug/mL N.D. N.D. -0.3 -0.3 +0.3
stress 7H9 with Ethionamide 0.1 ug/mL N.D. N.D. -0.6 +0.2 +0.1
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. N.D. -0.5 +0.2 +0.1
nitrogen source L-Asparagine 10 mM (N) N.D. N.D. +0.5 -0.7 +0.0
nitrogen source L-Serine 10 mM (N) N.D. N.D. +0.3 -0.6 +0.1
no stress control no stress control N.D. N.D. -0.4 +0.0 +0.3
no stress control no stress control N.D. N.D. +0.2 -0.4 +0.2
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. N.D. -0.3 +0.3 +0.1
stress 7H9 with para-aminosalicylic 0.086 ug/mL N.D. N.D. -0.3 +0.2 +0.3
carbon source L-Aspartic Acid (C) N.D. N.D. +0.5 -0.4 +0.2
carbon source Stearic 100 uM (C) N.D. N.D. +0.1 +0.4 -0.2
carbon source butyrate 10 mM (C) N.D. N.D. +0.4 +0.2 +0.1
carbon source Palmitic 100 uM (C) N.D. N.D. +0.1 +0.6 +0.1
stress 7H9 with Pretomanid 0.213 ug/mL N.D. N.D. +0.3 +0.3 +0.2
stress 7H9 with Pretomanid 0.213 ug/mL N.D. N.D. +0.4 +0.3 +0.1
carbon source butyrate 10 mM (C) N.D. N.D. +0.5 +0.4 +0.0
carbon source casaminos 1 mg/mL (C) N.D. N.D. +0.3 +0.5 +0.1
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