Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2599 and Rv2600 are separated by 81 nucleotidesRv2600 and Rv2601 overlap by 4 nucleotidesRv2601 and Rv2601A are separated by 110 nucleotidesRv2601A and Rv2602 overlap by 14 nucleotides Rv2599: Rv2599 - Probable conserved membrane protein, at 2,927,477 to 2,927,908 Rv2599 Rv2600: Rv2600 - Probable conserved integral membrane protein, at 2,927,990 to 2,928,391 Rv2600 Rv2601: Rv2601 - Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY), at 2,928,388 to 2,929,959 Rv2601 Rv2601A: Rv2601A - Possible antitoxin VapB41, at 2,930,070 to 2,930,357 Rv2601A Rv2602: Rv2602 - Possible toxin VapC41. Contains PIN domain., at 2,930,344 to 2,930,784 Rv2602
Group Condition Rv2599 Rv2600 Rv2601 Rv2601A Rv2602
stress 7H9 with Linezolid 0.3 ug/mL -0.1 -0.5 -0.2 N.D. -0.2
stress 7H9 with Vancomycin Hydrochloride from Streptomyces orientalis 0.012 mM -0.3 -0.1 -0.1 N.D. -0.4
carbon source D,L-Malic Acid 10 mM (C) -0.2 -0.2 -0.3 N.D. -0.1
stress 7H9 with Norfloxacin 0.125 mM -0.3 -0.2 +0.0 N.D. -0.3
carbon source casaminos 1 mg/mL (C) -0.3 -0.2 +0.0 N.D. -0.3
nitrogen source L-Valine 10 mM (N) -0.1 +0.0 -0.2 N.D. -0.4
pH pH 4.5 -0.3 -0.1 -0.4 N.D. +0.1
stress 7H9 with Formaldehyde 0.23 mM -0.2 +0.1 -0.2 N.D. -0.4
stress 7H9 with Chlorhexidine diacetate salt 0.0021 mM -0.3 -0.4 +0.2 N.D. -0.0
carbon source oleate 200uM (C) +0.2 -0.5 -0.1 N.D. -0.2
stress 7H9 with Ciprofloxacin Hydrochloride 0.0012 mM -0.3 -0.3 -0.1 N.D. +0.1
carbon source D-Trehalose 10 mM (C) +0.1 -0.3 -0.3 N.D. +0.0
stress 7H9 with Levofloxacin 0.3 ug/mL -0.4 +0.4 -0.2 N.D. -0.4
stress 7H9 with Phenazine methosulfate 0.0054 mM -0.3 -0.0 +0.2 N.D. -0.3
stress 7H9 with Levofloxacin 0.3 ug/mL -0.1 -0.0 +0.2 N.D. -0.5
stress 7H9 with Geneticin G418 0.35 mM +0.2 -0.3 +0.2 N.D. -0.3
stress 7H9 with Dibucaine 0.21 mM -0.2 +0.3 -0.0 N.D. -0.4
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM -0.2 +0.2 +0.1 N.D. -0.3
stress 7H9 with Amikacin di2 ug/mL +0.3 -0.1 -0.1 N.D. -0.3
pH 7H9 pH 5.5 +0.3 -0.4 +0.2 N.D. -0.1
stress 7H9 with Ethionamide 0.1 ug/mL +0.3 -0.4 +0.2 N.D. -0.0
stress 7H9 with Pretomanid 0.213 ug/mL +0.3 -0.1 +0.2 N.D. -0.2
stress 7H9 with hypochlorite 0.4 vol% +0.0 -0.3 +0.2 N.D. +0.4
stress 7H9 with Isoniazid 0.025 ug/mL +0.3 -0.3 +0.2 N.D. +0.2
no stress control no stress control +0.2 -0.2 +0.2 N.D. +0.3
stress 7H9 with nitrite 1.5 mM; pH 5.5 -0.2 +0.3 +0.2 N.D. +0.1
stress 7H9 with Nickel (II) chloride 0.6 mM +0.1 +0.4 +0.2 N.D. -0.2
stress 7H9 with Meropenem 9.6 ug/mL +0.5 -0.2 +0.0 N.D. +0.2
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM +0.1 -0.1 +0.1 N.D. +0.8
no stress control no stress control +0.5 +0.0 +0.1 N.D. +0.2
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