Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2590 and Rv2591 are separated by 173 nucleotidesRv2591 and Rv2592c are separated by 16 nucleotidesRv2592c and Rv2593c overlap by 4 nucleotidesRv2593c and Rv2594c overlap by 4 nucleotides Rv2590: Rv2590 - Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase), at 2,917,871 to 2,921,377 Rv2590 Rv2591: Rv2591 - PE-PGRS family protein PE_PGRS44, at 2,921,551 to 2,923,182 Rv2591 Rv2592c: Rv2592c - Probable holliday junction DNA helicase RuvB, at 2,923,199 to 2,924,233 Rv2592c Rv2593c: Rv2593c - Probable holliday junction DNA helicase RuvA, at 2,924,230 to 2,924,820 Rv2593c Rv2594c: Rv2594c - Probable crossover junction endodeoxyribonuclease RuvC (holliday junction nuclease) (holliday junction resolvase), at 2,924,817 to 2,925,383 Rv2594c
Group Condition Rv2590 Rv2591 Rv2592c Rv2593c Rv2594c
stress 7H9 with Rifampicin 0.014 ug/mL -0.0 -0.4 N.D. N.D. N.D.
stress 7H9 with Linezolid 0.44 ug/mL -0.1 -0.3 N.D. N.D. N.D.
stress 7H9 with Rifampicin 0.014 ug/mL -0.0 -0.3 N.D. N.D. N.D.
carbon source D,L-Malic Acid 10 mM (C) -0.0 -0.2 N.D. N.D. N.D.
stress 7H9 with Clofazimine 0.45 ug/mL -0.1 -0.2 N.D. N.D. N.D.
carbon source Stearic 100 uM (C) +0.0 -0.3 N.D. N.D. N.D.
stress 7H9 with Bedaquiline 0.15 ug/mL -0.1 -0.2 N.D. N.D. N.D.
no stress control no stress control -0.1 -0.2 N.D. N.D. N.D.
no stress control no stress control +0.0 -0.2 N.D. N.D. N.D.
nitrogen source L-Serine 10 mM (N) +0.0 -0.2 N.D. N.D. N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% +0.1 -0.2 N.D. N.D. N.D.
carbon source L-Lactate 10 mM (C) +0.1 -0.2 N.D. N.D. N.D.
stress 7H9 with Pretomanid 0.213 ug/mL +0.1 -0.1 N.D. N.D. N.D.
no stress control no stress control +0.2 -0.1 N.D. N.D. N.D.
stress 7H9 with Ethambutol 0.75 ug/mL +0.2 -0.1 N.D. N.D. N.D.
nitrogen source L-Valine 10 mM (N) -0.1 +0.2 N.D. N.D. N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.1 +0.2 N.D. N.D. N.D.
carbon source D,L-Malic Acid 10 mM (C) -0.0 +0.2 N.D. N.D. N.D.
carbon source butyrate 10 mM (C) +0.0 +0.2 N.D. N.D. N.D.
carbon source Glycerol (C) +0.1 +0.2 N.D. N.D. N.D.
stress 7H9 with Clofazimine 0.072 ug/mL +0.1 +0.1 N.D. N.D. N.D.
stress 7H9 with para-aminosalicylic 0.086 ug/mL +0.2 +0.1 N.D. N.D. N.D.
stress 7H9 with Isoniazid 0.025 ug/mL +0.1 +0.1 N.D. N.D. N.D.
carbon source L-Aspartic Acid (C) -0.0 +0.3 N.D. N.D. N.D.
carbon source propionate (C) +0.1 +0.1 N.D. N.D. N.D.
carbon source pyruvate (C) +0.0 +0.3 N.D. N.D. N.D.
carbon source Glycerol (C) +0.1 +0.2 N.D. N.D. N.D.
stress 7H9 with Pretomanid 0.213 ug/mL +0.2 +0.1 N.D. N.D. N.D.
carbon source pyruvate (C) +0.1 +0.3 N.D. N.D. N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL +0.1 +0.3 N.D. N.D. N.D.
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