Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2589 and Rv2590 are separated by 161 nucleotidesRv2590 and Rv2591 are separated by 173 nucleotidesRv2591 and Rv2592c are separated by 16 nucleotidesRv2592c and Rv2593c overlap by 4 nucleotides Rv2589: Rv2589 - 4-aminobutyrate aminotransferase GabT (gamma-amino-N-butyrate transaminase) (GABA transaminase) (glutamate:succinic semialdehyde transaminase) (GABA aminotransferase) (GABA-at), at 2,916,360 to 2,917,709 Rv2589 Rv2590: Rv2590 - Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase), at 2,917,871 to 2,921,377 Rv2590 Rv2591: Rv2591 - PE-PGRS family protein PE_PGRS44, at 2,921,551 to 2,923,182 Rv2591 Rv2592c: Rv2592c - Probable holliday junction DNA helicase RuvB, at 2,923,199 to 2,924,233 Rv2592c Rv2593c: Rv2593c - Probable holliday junction DNA helicase RuvA, at 2,924,230 to 2,924,820 Rv2593c
Group Condition Rv2589 Rv2590 Rv2591 Rv2592c Rv2593c
pH pH 4.5 -1.6 -0.6 -0.2 N.D. N.D.
pH pH 4.5 -1.5 -0.5 +0.0 N.D. N.D.
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -1.0 -0.1 +0.0 N.D. N.D.
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -0.9 -0.3 +0.2 N.D. N.D.
stress 7H9 with nitrate 4 mM -0.4 -0.3 -0.1 N.D. N.D.
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 -0.8 -0.0 +0.2 N.D. N.D.
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 -0.6 -0.1 -0.0 N.D. N.D.
stress 7H9 with Rifampicin 0.014 ug/mL -0.2 -0.0 -0.4 N.D. N.D.
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM -0.7 +0.0 +0.0 N.D. N.D.
stress 7H9 with Geneticin G418 0.35 mM -0.5 -0.0 -0.1 N.D. N.D.
stress 7H9 with Benzethonium chloride 0.068 mM -0.2 -0.1 -0.3 N.D. N.D.
pH 7H9 pH 5.5 -0.6 +0.0 -0.0 N.D. N.D.
stress 7H9 with hypochlorite 0.4 vol% -0.3 -0.0 -0.2 N.D. N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.5 +0.0 -0.0 N.D. N.D.
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM -0.5 +0.1 -0.1 N.D. N.D.
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM -0.7 +0.2 +0.0 N.D. N.D.
stress 7H9 with Sisomicin 0.07 mM -0.3 -0.2 +0.0 N.D. N.D.
stress 7H9 with nitrite 3 mM; pH 5.5 -0.5 +0.1 -0.1 N.D. N.D.
stress 7H9 with Dimethyl Sulfoxide 1 vol% -0.3 +0.1 -0.2 N.D. N.D.
no stress control no stress control -0.2 -0.3 +0.1 N.D. N.D.
stress 7H9 with nitrite 1.5 mM; pH 5.5 -0.7 +0.1 +0.2 N.D. N.D.
stress 7H9 with Cloxacillin 0.0386 mM -0.2 +0.1 -0.2 N.D. N.D.
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM -0.4 +0.3 -0.3 N.D. N.D.
stress 7H9 with Geneticin G418 0.35 mM -0.5 +0.0 +0.1 N.D. N.D.
stress 7H9 with Cumene hydroperoxide 0.05 mM -0.4 -0.1 +0.1 N.D. N.D.
stress 7H9 with nitrite 1.5 mM; pH 5.5 -0.7 +0.3 +0.1 N.D. N.D.
stress 7H9 with Formaldehyde 0.23 mM -0.3 -0.1 +0.2 N.D. N.D.
stress 7H9 with Isoniazid 0.025 ug/mL +0.4 +0.1 +0.1 N.D. N.D.
stress 7H9 with Malondialdehyde tetrabutylammonium salt 0.96 mM +0.3 -0.0 +0.3 N.D. N.D.
carbon source pyruvate (C) +0.3 +0.1 +0.3 N.D. N.D.
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