Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2588c and Rv2589 are separated by 166 nucleotidesRv2589 and Rv2590 are separated by 161 nucleotidesRv2590 and Rv2591 are separated by 173 nucleotidesRv2591 and Rv2592c are separated by 16 nucleotides Rv2588c: Rv2588c - Probable conserved membrane protein secretion factor YajC, at 2,915,846 to 2,916,193 Rv2588c Rv2589: Rv2589 - 4-aminobutyrate aminotransferase GabT (gamma-amino-N-butyrate transaminase) (GABA transaminase) (glutamate:succinic semialdehyde transaminase) (GABA aminotransferase) (GABA-at), at 2,916,360 to 2,917,709 Rv2589 Rv2590: Rv2590 - Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase), at 2,917,871 to 2,921,377 Rv2590 Rv2591: Rv2591 - PE-PGRS family protein PE_PGRS44, at 2,921,551 to 2,923,182 Rv2591 Rv2592c: Rv2592c - Probable holliday junction DNA helicase RuvB, at 2,923,199 to 2,924,233 Rv2592c
Group Condition Rv2588c Rv2589 Rv2590 Rv2591 Rv2592c
stress 7H9 with Levofloxacin 0.3 ug/mL -2.1 +0.1 +0.0 -0.1 N.D.
pH pH 4.5 +0.3 -1.6 -0.6 -0.2 N.D.
stress 7H9 with nitrite 2.5 mM -1.6 -0.2 -0.0 -0.1 N.D.
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -0.6 -1.0 -0.1 +0.0 N.D.
pH 7H9 pH 5.5 -1.2 -0.6 +0.0 -0.0 N.D.
no stress control no stress control -1.5 -0.1 -0.0 -0.0 N.D.
pH pH 4.5 +0.4 -1.5 -0.5 +0.0 N.D.
stress 7H9 with Sisomicin 0.07 mM -1.0 -0.3 -0.2 +0.0 N.D.
stress 7H9 with Cumene hydroperoxide 0.05 mM -1.1 -0.4 -0.1 +0.1 N.D.
nitrogen source L-Valine 10 mM (N) -1.1 -0.1 -0.0 -0.1 N.D.
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 -0.5 -0.8 -0.0 +0.2 N.D.
nitrogen source Urea 10mM (N) -1.1 -0.2 -0.0 +0.1 N.D.
stress 7H9 with Zinc Pyrithione 0.00072 mM -1.4 +0.0 +0.1 +0.1 N.D.
carbon source cholesterol 100uM (C) -1.3 +0.1 +0.0 +0.3 N.D.
stress 7H9 with Dodecyl Sulfate 0.02 vol% -1.1 -0.0 +0.1 +0.1 N.D.
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 +0.0 -0.9 -0.3 +0.2 N.D.
stress 7H9 with Phenazine methosulfate 0.0054 mM -1.1 +0.1 +0.1 -0.0 N.D.
carbon source propionate (C) -1.2 +0.1 +0.1 +0.1 N.D.
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM +0.5 -0.7 +0.2 +0.0 N.D.
stress 7H9 with nitrite 1.5 mM; pH 5.5 +0.2 -0.7 +0.3 +0.1 N.D.
stress 7H9 with Linezolid 0.44 ug/mL +0.9 +0.0 -0.1 -0.3 N.D.
stress 7H9 with Cloxacillin 0.0386 mM +1.0 -0.2 +0.1 -0.2 N.D.
stress 7H9 with Rifampicin 0.014 ug/mL +1.3 -0.2 -0.0 -0.4 N.D.
stress 7H9 with Bedaquiline 0.15 ug/mL +1.0 -0.1 -0.1 -0.2 N.D.
stress 7H9 with Ethambutol 0.75 ug/mL +1.0 -0.1 +0.2 -0.1 N.D.
stress 7H9 with Isoniazid 0.025 ug/mL +1.0 +0.4 -0.1 -0.0 N.D.
no stress control no stress control +1.0 +0.1 +0.0 +0.2 N.D.
stress 7H9 with Novobiocin 0.004 mM +1.5 -0.1 -0.0 -0.0 N.D.
stress 7H9 with Rifampicin 0.00045 ug/mL +1.4 +0.1 -0.1 -0.1 N.D.
stress 7H9 with Moxifloxacin 0.121 ug/mL +1.1 -0.1 +0.1 +0.3 N.D.
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