Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2587c and Rv2588c are separated by 109 nucleotidesRv2588c and Rv2589 are separated by 166 nucleotidesRv2589 and Rv2590 are separated by 161 nucleotidesRv2590 and Rv2591 are separated by 173 nucleotides Rv2587c: Rv2587c - Probable protein-export membrane protein SecD, at 2,914,015 to 2,915,736 Rv2587c Rv2588c: Rv2588c - Probable conserved membrane protein secretion factor YajC, at 2,915,846 to 2,916,193 Rv2588c Rv2589: Rv2589 - 4-aminobutyrate aminotransferase GabT (gamma-amino-N-butyrate transaminase) (GABA transaminase) (glutamate:succinic semialdehyde transaminase) (GABA aminotransferase) (GABA-at), at 2,916,360 to 2,917,709 Rv2589 Rv2590: Rv2590 - Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase), at 2,917,871 to 2,921,377 Rv2590 Rv2591: Rv2591 - PE-PGRS family protein PE_PGRS44, at 2,921,551 to 2,923,182 Rv2591
Group Condition Rv2587c Rv2588c Rv2589 Rv2590 Rv2591
nitrogen source L-Valine 10 mM (N) N.D. -1.2 -0.1 -0.1 -0.1
stress 7H9 with Dimethyl Sulfoxide 1 vol% N.D. -0.8 -0.3 +0.1 -0.2
no stress control no stress control N.D. -0.9 -0.2 -0.0 -0.0
nitrogen source L-Glutamic 10 mM (N) N.D. -0.8 -0.2 +0.0 -0.1
nitrogen source Glycine 10 mM (N) N.D. -0.7 -0.1 -0.1 -0.0
carbon source L-Asparagine (C) N.D. -0.6 -0.1 -0.1 -0.1
nitrogen source L-Glutamine 10 mM (N) N.D. -0.7 -0.1 -0.0 -0.1
nitrogen source L-Alanine 10 mM (N) N.D. -0.9 +0.0 +0.0 -0.0
stress 7H9 with Sulfamethizole 0.026 mM N.D. -0.7 -0.0 -0.1 -0.1
nitrogen source L-Aspartic Acid 10 mM (N) N.D. -0.6 +0.1 -0.0 -0.2
stress 7H9 with Meropenem 9.6 ug/mL N.D. -0.6 -0.2 +0.0 +0.0
carbon source L-Lactate 10 mM (C) N.D. -0.8 +0.1 +0.0 +0.0
carbon source propionate (C) N.D. -1.1 +0.1 +0.1 +0.1
nitrogen source L-Asparagine 10 mM (N) N.D. -0.5 -0.2 +0.0 +0.1
stress 7H9 with Streptomycin 0.178 ug/mL N.D. -0.8 +0.1 +0.0 +0.1
stress 7H9 with Ethionamide 0.1 ug/mL N.D. -0.7 +0.3 +0.0 -0.0
carbon source D-Glucose (C) N.D. -0.5 +0.3 +0.1 +0.1
stress 7H9 with Dimethyl Sulfoxide 1 vol% N.D. +0.6 -0.5 +0.0 -0.1
stress 7H9 with Clofazimine 0.45 ug/mL N.D. +0.5 -0.1 -0.1 -0.2
stress 7H9 with Linezolid 0.44 ug/mL N.D. +0.8 +0.0 -0.1 -0.3
stress 7H9 with Rifampicin 0.014 ug/mL N.D. +1.2 -0.2 -0.0 -0.4
stress 7H9 with Levofloxacin 0.3 ug/mL N.D. +0.7 -0.3 +0.1 +0.0
stress 7H9 with Bedaquiline 0.15 ug/mL N.D. +0.9 -0.1 -0.1 -0.2
stress 7H9 with Ethambutol 0.75 ug/mL N.D. +0.7 -0.0 +0.1 -0.1
no stress control no stress control N.D. +0.7 +0.1 +0.0 -0.1
stress 7H9 with Ethambutol 0.75 ug/mL N.D. +0.8 -0.1 +0.2 -0.1
stress 7H9 with Isoniazid 0.025 ug/mL N.D. +0.3 +0.4 +0.1 +0.1
stress 7H9 with Rifampicin 0.00045 ug/mL N.D. +1.2 +0.1 -0.1 -0.1
stress 7H9 with Moxifloxacin 0.121 ug/mL N.D. +0.9 -0.0 +0.1 +0.3
stress 7H9 with Isoniazid 0.025 ug/mL N.D. +1.1 +0.4 -0.1 -0.0
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