Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2494 and Rv2495c are separated by 22 nucleotidesRv2495c and Rv2496c overlap by 4 nucleotidesRv2496c and Rv2497c are separated by 10 nucleotidesRv2497c and Rv2498c are separated by 258 nucleotides Rv2494: Rv2494 - Possible toxin VapC38. Contains PIN domain., at 2,808,310 to 2,808,735 Rv2494 Rv2495c: Rv2495c - Probable branched-chain keto acid dehydrogenase E2 component BkdC, at 2,808,758 to 2,809,939 Rv2495c Rv2496c: Rv2496c - Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB, at 2,809,936 to 2,810,982 Rv2496c Rv2497c: Rv2497c - Probable branched-chain keto acid dehydrogenase E1 component, alpha subunit BkdA, at 2,810,993 to 2,812,096 Rv2497c Rv2498c: Rv2498c - Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase), at 2,812,355 to 2,813,176 Rv2498c
Group Condition Rv2494 Rv2495c Rv2496c Rv2497c Rv2498c
stress 7H9 with Levofloxacin 0.3 ug/mL N.D. N.D. -1.3 +0.0 -0.3
carbon source Glycerol (C) N.D. N.D. -0.7 -0.8 +0.1
carbon source L-Asparagine (C) N.D. N.D. -1.1 -0.6 +0.4
carbon source Glycerol (C) N.D. N.D. -0.8 -0.8 +0.2
nitrogen source L-Asparagine 10 mM (N) N.D. N.D. -0.6 -0.6 -0.1
carbon source L-Glutamine (C) N.D. N.D. -0.8 -0.4 +0.0
nitrogen source L-Aspartic Acid 10 mM (N) N.D. N.D. -0.7 -0.5 +0.1
nitrogen source L-Asparagine 10 mM (N) N.D. N.D. -0.8 -0.4 +0.1
carbon source D-Glucose (C) N.D. N.D. -0.6 -0.5 +0.1
nitrogen source Glycine 10 mM (N) N.D. N.D. -0.7 -0.4 +0.0
carbon source L-Glutamine (C) N.D. N.D. -0.6 -0.6 +0.2
nitrogen source L-Aspartic Acid 10 mM (N) N.D. N.D. -0.4 -0.5 -0.1
carbon source L-Asparagine (C) N.D. N.D. -0.6 -0.5 +0.2
nitrogen source L-Alanine 10 mM (N) N.D. N.D. -0.5 -0.2 -0.2
carbon source L-Lactate 10 mM (C) N.D. N.D. -0.4 -0.7 +0.1
nitrogen source Glycine 10 mM (N) N.D. N.D. -0.3 -0.3 -0.3
no stress control no stress control N.D. N.D. -0.6 +0.1 -0.4
carbon source D-Trehalose 10 mM (C) N.D. N.D. -0.7 -0.6 +0.4
carbon source pyruvate (C) N.D. N.D. -0.8 -0.2 +0.2
stress 7H9 with Dimethyl Sulfoxide 1 vol% N.D. N.D. +0.1 -0.3 -0.6
nitrogen source L-Glutamine 10 mM (N) N.D. N.D. -0.5 -0.3 +0.0
carbon source casaminos 1 mg/mL (C) N.D. N.D. -0.3 -0.6 +0.2
carbon source D-Glucose (C) N.D. N.D. -0.3 -0.5 +0.2
carbon source butyrate 10 mM (C) N.D. N.D. -0.1 -0.5 +0.2
nitrogen source L-Glutamine 10 mM (N) N.D. N.D. +0.2 -0.3 -0.3
stress 7H9 with Isoniazid 0.025 ug/mL N.D. N.D. +0.0 +0.3 -0.7
carbon source D-Trehalose 10 mM (C) N.D. N.D. -0.3 -0.3 +0.3
carbon source L-Aspartic Acid (C) N.D. N.D. -0.4 -0.3 +0.4
stress 7H9 with Ethionamide 0.1 ug/mL N.D. N.D. +0.8 +0.3 -0.8
carbon source Valeric 10 mM (C) N.D. N.D. +0.6 +0.3 +0.1
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