Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2474c and Rv2475c are separated by 5 nucleotidesRv2475c and Rv2476c overlap by 4 nucleotidesRv2476c and Rv2477c are separated by 103 nucleotidesRv2477c and Rv2478c are separated by 80 nucleotides Rv2474c: Rv2474c - Conserved hypothetical protein, at 2,776,316 to 2,776,969 Rv2474c Rv2475c: Rv2475c - Conserved protein, at 2,776,975 to 2,777,391 Rv2475c Rv2476c: Rv2476c - Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase), at 2,777,388 to 2,782,262 Rv2476c Rv2477c: Rv2477c - Probable macrolide-transport ATP-binding protein ABC transporter, at 2,782,366 to 2,784,042 Rv2477c Rv2478c: Rv2478c - Conserved hypothetical protein, at 2,784,123 to 2,784,608 Rv2478c
Group Condition Rv2474c Rv2475c Rv2476c Rv2477c Rv2478c
nitrogen source L-Asparagine 10 mM (N) -0.3 -0.8 -2.0 N.D. -0.4
carbon source propionate (C) -0.3 -0.4 -2.3 N.D. -0.3
carbon source Stearic 100 uM (C) -0.3 -0.2 -2.3 N.D. -0.3
carbon source butyrate 10 mM (C) -0.6 +0.0 -2.6 N.D. +0.2
carbon source Stearic 100 uM (C) +0.1 +0.1 -2.9 N.D. -0.3
carbon source D-Glucose (C) -0.3 -0.0 -2.3 N.D. -0.2
nitrogen source L-Asparagine 10 mM (N) -0.3 -0.2 -2.1 N.D. -0.2
carbon source heptadecanoic 250 uM (C) -0.3 -0.2 -1.8 N.D. -0.4
carbon source heptadecanoic 250 uM (C) -0.4 +0.0 -2.0 N.D. -0.2
carbon source D-Lactate 10 mM (C) -0.0 -0.5 -2.1 N.D. +0.1
carbon source L-Aspartic Acid (C) -0.5 -0.3 -1.6 N.D. -0.1
carbon source D-Glucose (C) -0.1 -0.2 -2.1 N.D. -0.0
carbon source pyruvate (C) +0.5 -0.2 -2.6 N.D. -0.1
carbon source acetate (C) +0.1 -0.3 -2.3 N.D. +0.1
stress 7H9 with Ethambutol 0.75 ug/mL -0.3 -0.4 -1.7 N.D. +0.1
carbon source pyruvate (C) +0.3 -0.6 -2.0 N.D. -0.1
carbon source Glycerol (C) +0.4 +0.2 -2.8 N.D. -0.0
stress 7H9 with Bedaquiline 0.15 ug/mL +0.2 -0.4 -1.8 N.D. +0.2
carbon source Glycerol (C) +0.6 +0.2 -2.5 N.D. +0.0
carbon source D-Lactate 10 mM (C) +0.1 +0.1 -2.1 N.D. +0.4
carbon source Valeric 10 mM (C) +0.3 +0.3 -1.9 N.D. -0.1
carbon source L-Glutamine (C) +0.3 +0.3 -1.7 N.D. -0.4
stress 7H9 with Moxifloxacin 0.121 ug/mL -1.3 +0.4 -0.5 N.D. +0.3
stress 7H9 with Bedaquiline 0.15 ug/mL +1.3 +0.1 -1.7 N.D. -0.0
stress 7H9 with Rifampicin 0.00045 ug/mL +0.9 -0.5 -1.1 N.D. +0.4
stress 7H9 with Rifampicin 0.014 ug/mL +1.0 +0.0 -1.4 N.D. +0.3
stress 7H9 with Isoniazid 0.025 ug/mL +0.8 +0.9 -0.5 N.D. -0.2
stress 7H9 with Dimethyl Sulfoxide 1 vol% +0.8 -0.1 +1.3 N.D. -0.3
no stress control no stress control +0.8 +0.7 +0.6 N.D. -0.3
stress 7H9 with Dimethyl Sulfoxide 1 vol% +0.8 +0.3 +1.1 N.D. -0.3
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