Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv2423 and Rv2424c are separated by 132 nucleotidesRv2424c and Rv2425c are separated by 88 nucleotidesRv2425c and Rv2426c overlap by 1 nucleotidesRv2426c and Rv2427c are separated by 46 nucleotides Rv2423: Rv2423 - Hypothetical protein, at 2,719,597 to 2,720,643 Rv2423 Rv2424c: Rv2424c - Probable transposase, at 2,720,776 to 2,721,777 Rv2424c Rv2425c: Rv2425c - Conserved hypothetical protein, at 2,721,866 to 2,723,308 Rv2425c Rv2426c: Rv2426c - Conserved hypothetical protein, at 2,723,308 to 2,724,183 Rv2426c Rv2427c: Rv2427c - Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialdehyde dehydrogenase), at 2,724,230 to 2,725,477 Rv2427c
Group Condition Rv2423 Rv2424c Rv2425c Rv2426c Rv2427c
stress 7H9 with Isoniazid 0.025 ug/mL -0.1 N.D. -0.1 -0.3 -1.2
stress 7H9 with nitrite 3 mM; pH 5.5 -0.0 N.D. +0.0 -0.2 -1.0
stress 7H9 with Ciprofloxacin Hydrochloride 0.001 mM -0.2 N.D. -0.1 -0.3 -0.5
stress 7H9 with Cetrimonium bromide 0.015 vol% -0.1 N.D. -0.1 -0.4 -0.4
nitrogen source L-Valine 10 mM (N) -0.1 N.D. -0.1 -0.7 -0.1
stress 7H9 with Isoniazid 0.025 ug/mL -0.0 N.D. +0.1 -0.0 -0.9
pH pH 4.5 +0.0 N.D. -0.0 +0.2 -1.0
stress 7H9 with nitrite 1.5 mM; pH 5.5 -0.0 N.D. +0.1 -0.3 -0.6
carbon source propionate (C) +0.1 N.D. +0.1 -0.2 -0.8
stress 7H9 with Ethionamide 0.1 ug/mL -0.1 N.D. -0.0 +0.2 -0.7
stress 7H9 with Zinc Pyrithione 0.00072 mM -0.1 N.D. +0.2 +0.0 -0.7
stress 7H9 with Hydrogen peroxide 3.97 mM -0.1 N.D. +0.2 -0.2 -0.5
pH pH 4.5 -0.1 N.D. +0.3 +0.1 -0.7
stress 7H9 with Ethambutol 0.75 ug/mL +0.2 N.D. +0.2 -0.3 -0.3
no stress control no stress control +0.1 N.D. -0.1 +0.4 -0.7
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 -0.0 N.D. +0.4 -0.4 -0.2
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 5.5 +0.2 N.D. +0.2 +0.2 -0.5
stress 7H9 with Antimycin A 0.0186 mM -0.1 N.D. +0.3 +0.3 -0.4
stress 7H9 with Pyrazinamide 50 ug/mL; pH 5.5 +0.2 N.D. +0.1 +0.4 -0.4
stress 7H9 with Ciprofloxacin Hydrochloride 0.0012 mM +0.2 N.D. -0.0 -0.5 +0.5
nitrogen source Ammonium chloride 10mM (N) +0.1 N.D. -0.2 +0.2 +0.4
nitrogen source Ammonium chloride 10mM (N) +0.2 N.D. -0.2 +0.4 +0.2
stress 7H9 with Novobiocin 0.004 mM +0.1 N.D. -0.2 +0.3 +0.6
no stress control no stress control -0.1 N.D. +0.0 +0.6 +0.3
stress 7H9 with Chloramphenicol 0.01 mM +0.1 N.D. -0.0 +0.5 +0.4
nitrogen source L-Aspartic Acid 10 mM (N) -0.0 N.D. +0.3 +0.3 +0.4
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM -0.0 N.D. +0.2 +0.3 +0.7
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM -0.0 N.D. +0.3 +0.5 +0.6
stress 7H9 with 2-bromo-2-nitro-1,3-propanediol 0.1 mM -0.2 N.D. +0.4 +0.6 +0.6
stress 7H9 with 2-Mercaptopyridine N-oxide 0.0078 mM +0.1 N.D. +0.1 +0.5 +0.8
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